scholarly journals The Use of Cell Proliferation Data in Modeling of Skin Carcinogenesis

1993 ◽  
Vol 101 ◽  
pp. 103
Author(s):  
Annette Kopp-Schneider
Keyword(s):  
Cell Proliferation ◽  
Skin Carcinogenesis

scholarly journals Relationship of p53 Mutations to Epidermal Cell Proliferation and Apoptosis in Human UV-Induced Skin Carcinogenesis

Neoplasia ◽  
1999 ◽  
Vol 1 (5) ◽  
pp. 468-475 ◽  
Author(s):  
Janine G. Einspahr ◽  
David S. Alberts ◽  
James A. Wameke ◽  
Paul Bozzo ◽  
Jenny Basye ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Epidermal Cell ◽  
Skin Carcinogenesis ◽  
P53 Mutations ◽  
Proliferation And Apoptosis ◽  
Relationship Of ◽  
Epidermal Cell Proliferation

scholarly journals Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126459 ◽  
Author(s):  
Wenjuan Li ◽  
Chunjing Zhang ◽  
Amy Ren ◽  
Teena Li ◽  
Rong Jin ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Skin Carcinogenesis

scholarly journals Wnt/β-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Jing Li ◽  
Ling Ji ◽  
Jieping Chen ◽  
Wengeng Zhang ◽  
Zhijia Ye
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Skin Cancer ◽  
Cancer Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Adult Stem Cells ◽  
Adult Life ◽  
Skin Carcinogenesis ◽  
Wnt Pathways

Cooperating with other signaling pathways, Wnt signaling controls cell proliferation, morphology, motility, and embryonic development destination and maintains the homeostasis of tissues including skin, blood, intestine, and brain by regulating somatic stem cells and their niches throughout adult life. Abnormal regulation of Wnt pathways leads to neoplastic proliferation in these tissues. Recent research shows that Wnt signaling is also associated with the regulation of cancer stem cells (CSCs) through a similar mechanism to that observed in normal adult stem cells. Thus, the Wnt/β-catenin signaling pathway has been intensively studied and characterized. For this review, we will focus on the regulation of the Wnt/β-catenin signaling pathway in skin cancer. With the important role in stemness and skin CSC proliferation, the Wnt/β-catenin signaling pathway and its elements have the potential to be targets for skin cancer therapy.

scholarly journals SMAD7 in keratinocytes promotes skin carcinogenesis by activating ATM-dependent DNA repair and an EGFR-mediated cell proliferation pathway

2018 ◽  
Vol 40 (1) ◽  
pp. 112-120 ◽  
Author(s):  
Huyen Trang Ha Thi ◽  
Hye-Youn Kim ◽  
Young-Jae Lee ◽  
Seong-Jin Kim ◽  
Suntaek Hong
Keyword(s):  
Cell Proliferation ◽  
Dna Repair ◽  
Skin Carcinogenesis

Fibroblasts During Hypertrophic Scar Formation and Resolution

1973 ◽  
Vol 31 ◽  
pp. 428-429
Author(s):  
C. W. Kischer
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Cell Proliferation ◽  
Fine Structure ◽  
Metabolic Activity ◽  
Hypertrophic Scar ◽  
Normal Skin ◽  
Ground Substance ◽  
Hypertrophic Scars ◽  
Scanning Electron

The morphology of the fibroblasts changes markedly as the healing period from burn wounds progresses, through development of the hypertrophic scar, to resolution of the scar by a self-limiting process of maturation or therapeutic resolution. In addition, hypertrophic scars contain an increased cell proliferation largely made up of fibroblasts. This tremendous population of fibroblasts seems congruous with the abundance of collagen and ground substance. The fine structure of these cells should reflect some aspects of the metabolic activity necessary for production of the scar, and might presage the stage of maturation.A comparison of the fine structure of the fibroblasts from normal skin, different scar types, and granulation tissue has been made by transmission (TEM) and scanning electron microscopy (SEM).

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