scholarly journals Epidemiologic Study Design for Investigating Respiratory Health Effects of Complex Air Pollution Mixtures

1993 ◽  
Vol 101 ◽  
pp. 187 ◽  
Author(s):  
Douglas W. Dockery
Keyword(s):  
Air Pollution ◽  
Health Effects ◽  
Study Design ◽  
Respiratory Health ◽  
Epidemiologic Study ◽  
Air Pollution Mixtures ◽  
Pollution Mixtures

Abstract MP61: A Multi-pollutant, Multi-ethnic, and Methylome-wide Association Study Highlights Epigenetic Effects of Exposure to Ambient Air Pollution Mixtures

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Antoine R Baldassari ◽  
Rahul Gondalia ◽  
Katelyn M Holliday ◽  
Raul Méndez-Giráldez ◽  
Anne E Justice ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Air Pollution ◽  
Environmental Protection Agency ◽  
Fixed Effects ◽  
Biological Systems ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Cpg Sites ◽  
Air Pollution Mixtures ◽  
Pollution Mixtures

Background: Ambient air pollution mixtures including fine particulates and gases have been associated with cardiovascular disease (CVD). Although mechanisms underlying the associations remain largely uncharacterized to date, examining epigenetic responses to air pollution mixtures may identify biological systems affected by exposure and provide insight into the pathophysiology and environmental epidemiology of CVD. Therefore, we undertook a multi-pollutant, methylome-wide study of associations between DNA methylation (DNAm) at 485,000 Cytosine-phosphate-Guanine (CpG) sites and pollutants regulated by the U.S. Environmental Protection Agency under the Clean Air Act. Methods: Data from the Atherosclerosis Risk in Communities Study and three sub-studies within the Women’s Health Initiative (WHI) included information on 8,567 participants, 83% of whom were women, 46% African American, and 9% Hispanic/Latino (mean age, 61.3 years). Daily mean, geocoded participant address-specific concentrations of ambient particulate matter with diameter ≤ 10μm (PM 10 ), ≤2.5μm (PM 2.5 ), and 2.5-10μm (PM 2.5-10 ); ozone (O 3 ); nitrogen dioxide (NO 2 ); nitrogen oxides (NO x ); carbon monoxide (CO); and sulfur dioxide (SO 2 ) were averaged over 2, 7, 28, and 365 days before measurement of leukocyte DNAm in whole blood. Methylome-wide, pollutant-DNAm associations were estimated separately at each averaging period in each stratum defined by race/ethnicity and study using multi-level, linear mixed models adjusting for socio-demographic, behavioral, and meteorological characteristics; estimated leukocyte proportions; and technical covariates. Estimates were combined across strata in pollutant- and period-specific, fixed-effects, inverse-variance weighted meta-analyses. Then multi-pollutant, period-specific effects were examined using the adaptive sum of powered scores (U) test (aSPU). CpG sites associated with multi-pollutant significance (aSPU P < 1.0 x 10 -7 ) were characterized in silico to assess their putative function and biological plausibility. Results: Overall analyses identified a significant, 28-day mean, multi-pollutant association at cg15008743 near ZNF83 on chromosome 19 (p = 1x10 -7 ) and a highly-suggestive 28-day mean, multipollutant association at cg00489219 near ZNF621 on chromosome 3 (p = 5x10 -7 ). ZNF83 and ZNF621 encode zinc finger proteins with a potentially broad reach across biological systems given their transcription factor, metal, and DNA binding activities. ZNF621 also harbors rare genetic variants with large effects on blood pressure. Discussion: Methylome-wide associations of DNAm with EPA-regulated ambient air pollutants suggest biologically plausible pathways underpinning the increasingly well-documented ties between multi-pollutant mixtures and cardiovascular disease.

Traffic-Related Air Pollution Exposures and Respiratory Health: A Study Design of the Schoolchildren Cohort in the Sora Project

Epidemiology ◽  
2006 ◽  
Vol 17 (Suppl) ◽  
pp. S262
Author(s):  
H Nitta ◽  
T Ohara ◽  
M Ono ◽  
T Sato ◽  
M Shima ◽  
...  
Keyword(s):  
Air Pollution ◽  
Study Design ◽  
Respiratory Health

Respiratory Health Effects of Ambient Air Pollution

2012 ◽  
Vol 33 (4) ◽  
pp. 759-769 ◽  
Author(s):  
Francesco Sava ◽  
Chris Carlsten
Keyword(s):  
Air Pollution ◽  
Health Effects ◽  
Respiratory Health ◽  
Ambient Air ◽  
Ambient Air Pollution

scholarly journals Review of epidemiological studies on air pollution and health effects in children

2021 ◽  
Vol 64 (1) ◽  
pp. 3-11
Author(s):  
Jong-Tae Lee
Keyword(s):  
Air Pollution ◽  
Health Effects ◽  
Respiratory Health ◽  
Ambient Air ◽  
Epidemiological Studies ◽  
Ambient Air Pollution ◽  
Neurodevelopmental Outcomes ◽  
Critical Window ◽  
Adverse Health Effects ◽  
Adverse Health

There is a growing body of literature on the adverse health effects of ambient air pollution. Children are more adversely affected by air pollution due to their biological susceptibility and exposure patterns. This review summarized the accumulated epidemiologic evidence with emphasis on studies conducted in Korea and heterogeneity in the literature. Based on systematic reviews and meta-analyses, there is consistent evidence on the association between exposure to ambient air pollution and children’s health, especially respiratory health and adverse birth outcomes, and growing evidence on neurodevelopmental outcomes. Despite these existing studies, the mechanism of the adverse health effects of air pollution and the critical window of susceptibility remain unclear. There is also a need to identify causes of heterogeneity between studies in terms of measurement of exposure/outcome, study design, and the differential characteristics of air pollutants and population.

Regional air pollution mixtures across the continental US

2019 ◽  
Vol 213 ◽  
pp. 258-272
Author(s):  
Weeberb J. Requia ◽  
Brent A. Coull ◽  
Petros Koutrakis
Keyword(s):  
Air Pollution ◽  
Air Pollution Mixtures ◽  
Pollution Mixtures ◽  
Regional Air Pollution
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