Epidemiology of Disability in the Oldest Old: Methodologic Issues and Preliminary Findings

1985 ◽  
Vol 63 (2) ◽  
pp. 350 ◽  
Author(s):  
Joan C. Cornoni-Huntley ◽  
Daniel J. Foley ◽  
Lon R. White ◽  
Richard Suzman ◽  
Lisa F. Berkman ◽  
...  
Keyword(s):  
Oldest Old

Caregiving in Advanced Years: The Oldest Old As Our Caregivers

2010 ◽  
Author(s):  
Maureen K. Keaveny ◽  
Vitae Felix ◽  
Terrance L. Walker ◽  
David W. Coon
Keyword(s):  
Oldest Old

Social Engagement and Communicative Skills in the Oldest Old

2004 ◽  
Author(s):  
Deborah Keller-Cohen ◽  
Diane L. Miller ◽  
Katherine L. Fiori
Keyword(s):  
Social Engagement ◽  
Oldest Old ◽  
Communicative Skills

Is Alzheimer disease a failure of mobilizing immune defense? Lessons from cognitively fit oldest-old

2019 ◽  
Vol 21 (1) ◽  
pp. 7-19 ◽  
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Aging ◽  
Oldest Old ◽  
Adaptive Immune Response ◽  
Effector T Cells ◽  
Immune Defense ◽  
Supporting Evidence ◽  
Therapeutic Approaches ◽  
Related Data ◽  
Adaptive Immune

Multifaceted evidence supports the hypothesis that inflammatory-immune mechanisms contribute to Alzheimer disease (AD) neuropathology and genetic association of several immune specific genes (TREM2, CR1, and CD33) suggests that maladaptive immune responses may be pivotal drivers of AD pathogenesis. We reviewed microglia-related data from postmortem AD studies and examined supporting evidence from AD animal models to answer the following questions: i) What is the temporal sequence of immune activation in AD progression and what is its impact on cognition? ii) Are there discordant, "primed", microglia responses in AD vs successful cognitive aging? iii) Does central nervous system (CNS) repair in aging depend on recruitment of the elements of cellular adaptive immune response such as effector T cells, and can the recruitment of systemic immune cells ameliorate AD neuropathology? iv) How effective are the immune-system-based therapeutic approaches currently employed for the treatment of AD?

Treating Cancer and No-Cancer Pain in Older and Oldest Old Patients

2015 ◽  
Vol 21 (13) ◽  
pp. 1706-1714 ◽  
Author(s):  
G. Colloca ◽  
F. Lattanzio ◽  
L. Balducci ◽  
G. Onder ◽  
G. Ronconi ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Oldest Old ◽  
Old Patients
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