Schistosoma mansoni: IL-4 Is Necessary for Concomitant Immunity in Mice

1999 ◽  
Vol 85 (4) ◽  
pp. 734 ◽  
Author(s):  
Laura Rosa Brunet ◽  
Manfred A. Kopf ◽  
Edward J. Pearce
Keyword(s):  
Schistosoma Mansoni ◽  
Concomitant Immunity

scholarly journals Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection

2004 ◽  
Vol 46 (4) ◽  
pp. 231-233 ◽  
Author(s):  
Fabio Ribeiro ◽  
Rômulo Teixeira de Mello ◽  
Carlos Alberto Pereira Tavares ◽  
John Robert Kusel ◽  
Paulo Marcos Zech Coelho
Keyword(s):  
Immune Response ◽  
Schistosoma Mansoni ◽  
Worm Burden ◽  
Synergistic Action ◽  
Specific Immune Response ◽  
Concomitant Immunity

The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase.

scholarly journals Schistosoma mansoni: importance of skin and pulmonary phases to concomitant immunity in albino mice

1985 ◽  
Vol 27 (2) ◽  
pp. 86-88 ◽  
Author(s):  
Miriam O. Rocha ◽  
Paulo Marcos Z. Coelho ◽  
Rômulo T. Mello
Keyword(s):  
Portal Vein ◽  
Schistosoma Mansoni ◽  
Statistical Difference ◽  
Control Group ◽  
Concomitant Immunity ◽  
Albino Mice

Fourteen-day-old schistosomula obtained from mice previously infected were surgically transferred to the portal vein of receptor mice. Another group of mice was infected with cercariae by transcutaneous route. After 90 days, those groups were challenged with 100 cercariae, transcutaneously, as well as a control group. Two weeks later the animals were perfused and mature and immature worms counted separately. Statistically significant differences were observed in the recovery of immature worms, when the control group was compared with those twice infected. No statistical difference was detected between the group infected transcutaneously, and that infected by worm inoculation in portal vein. Results demonstrated that suppression of skin and lung migration of the parasite does not interfere with the development of the so called concomitant immunity.

scholarly journals Concomitant Immunity to Schistosoma mansoni in Mice

2013 ◽  
Vol 37 (1) ◽  
pp. 19-22 ◽  
Author(s):  
Abdel-Moneim Salim ◽  
Abdel-Rahman Al-Humiany
Keyword(s):  
Schistosoma Mansoni ◽  
Concomitant Immunity

scholarly journals Delayed tail loss during the invasion of human skin by schistosome cercariae

Parasitology ◽  
2003 ◽  
Vol 126 (2) ◽  
pp. 135-140 ◽  
Author(s):  
P. J. WHITFIELD ◽  
A. BARTLETT ◽  
N. KHAMMO ◽  
A. P. R. BRAIN ◽  
M. B. BROWN ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Schistosoma Mansoni ◽  
Stratum Corneum ◽  
Human Skin ◽  
Adaptive Trait ◽  
Human Keratinocyte ◽  
Concomitant Immunity ◽  
Scanning Electron ◽  
Infection Experiments

Schistosomiasis is initiated when cercarial larvae invade human skin. Contrary to long-held assumptions, most cercariae of Schistosoma mansoni do not shed their propulsive tails as they penetrate. Scanning electron microscopy studies and infection experiments with entire human skin and differentiated, stratum corneum-like, human keratinocyte cultures, have shown that most cercarial tails enter the skin along with their bodies. We propose that this behaviour is an adaptive trait linked with concomitant immunity.

Ultrastructural analysis of “Sensory” surface nerve endings and “putative” neurotransmitter sites in Schistosoma mansoni Miracidia

1989 ◽  
Vol 47 ◽  
pp. 962-963
Author(s):  
Betty Ruth Jones ◽  
Steve Chi-Tang Pan
Keyword(s):  
Nervous System ◽  
Life Cycle ◽  
Schistosoma Mansoni ◽  
Snail Host ◽  
Complex Life Cycle ◽  
Rational Approach ◽  
Effective Control ◽  
The Social ◽  
Social And Economic Development ◽  
Basic Biology

INTRODUCTION: Schistosomiasis has been described as “one of the most devastating diseases of mankind, second only to malaria in its deleterious effects on the social and economic development of populations in many warm areas of the world.” The disease is worldwide and is probably spreading faster and becoming more intense than the overall research efforts designed to provide the basis for countering it. Moreover, there are indications that the development of water resources and the demands for increasing cultivation and food in developing countries may prevent adequate control of the disease and thus the number of infections are increasing.Our knowledge of the basic biology of the parasites causing the disease is far from adequate. Such knowledge is essential if we are to develop a rational approach to the effective control of human schistosomiasis. The miracidium is the first infective stage in the complex life cycle of schistosomes. The future of the entire life cycle depends on the capacity and ability of this organism to locate and enter a suitable snail host for further development, Little is known about the nervous system of the miracidium of Schistosoma mansoni and of other trematodes. Studies indicate that miracidia contain a well developed and complex nervous system that may aid the larvae in locating and entering a susceptible snail host (Wilson, 1970; Brooker, 1972; Chernin, 1974; Pan, 1980; Mehlhorn, 1988; and Jones, 1987-1988).

In vitro schistosomicidal activity of Usnea steineri extract and its major constituent (+)-usnic acid against Schistosoma mansoni

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
AIO Salloum ◽  
R Lucarini ◽  
MG Tozatti ◽  
J Medeiros ◽  
MLA Silva ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Usnic Acid ◽  
Major Constituent
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