The Susceptibility of Lymnaea fuscus to Experimental Infection with Fasciola hepatica

2000 ◽  
Vol 86 (1) ◽  
pp. 158
Author(s):  
G. Dreyfuss ◽  
M. Abrous ◽  
D. Rondelaud
Keyword(s):  
Experimental Infection ◽  
Fasciola Hepatica

scholarly journals Recognition Pattern of the Fasciola hepatica Excretome/Secretome during the Course of an Experimental Infection in Sheep by 2D Immunoproteomics

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 725
Author(s):  
David Becerro-Recio ◽  
Javier González-Miguel ◽  
Alberto Ucero ◽  
Javier Sotillo ◽  
Álvaro Martínez-Moreno ◽  
...  
Keyword(s):  
Experimental Infection ◽  
Fasciola Hepatica ◽  
Cathepsin L ◽  
Helminth Parasites ◽  
Glutathione S Transferase ◽  
Serum Samples ◽  
Secretory Products ◽  
Immunogenic Proteins ◽  
Host Parasite ◽  
First Time

Excretory/secretory products released by helminth parasites have been widely studied for their diagnostic utility, immunomodulatory properties, as well as for their use as vaccines. Due to their location at the host/parasite interface, the characterization of parasite secretions is important to unravel the molecular interactions governing the relationships between helminth parasites and their hosts. In this study, the excretory/secretory products from adult worms of the trematode Fasciola hepatica (FhES) were employed in a combination of two-dimensional electrophoresis, immunoblot and mass spectrometry, to analyze the immune response elicited in sheep during the course of an experimental infection. Ten different immunogenic proteins from FhES recognized by serum samples from infected sheep at 4, 8, and/or 12 weeks post-infection were identified. Among these, different isoforms of cathepsin L and B, peroxiredoxin, calmodulin, or glutathione S-transferase were recognized from the beginning to the end of the experimental infection, suggesting their potential role as immunomodulatory antigens. Furthermore, four FhES proteins (C2H2-type domain-containing protein, ferritin, superoxide dismutase, and globin-3) were identified for the first time as non-immunogenic proteins. These results may help to further understand host/parasite relationships in fasciolosis, and to identify potential diagnostic molecules and drug target candidates of F. hepatica.

Horses are susceptible to natural, but resistant to experimental, infection with the liver fluke, Fasciola hepatica

2020 ◽  
Vol 281 ◽  
pp. 109094 ◽  
Author(s):  
A. Quigley ◽  
M. Sekiya ◽  
A. Garcia-Campos ◽  
A. Paz-Silva ◽  
A. Howell ◽  
...  
Keyword(s):  
Experimental Infection ◽  
Liver Fluke ◽  
Fasciola Hepatica

Role of the lymnaeid snailPseudosuccinea columellain the transmission of the liver flukeFasciola hepaticain Egypt

2014 ◽  
Vol 89 (6) ◽  
pp. 699-706 ◽  
Author(s):  
Y. Dar ◽  
P. Vignoles ◽  
D. Rondelaud ◽  
G. Dreyfuss
Keyword(s):  
Microsatellite Markers ◽  
Intermediate Host ◽  
Larval Development ◽  
Experimental Infection ◽  
Fasciola Hepatica ◽  
Experimental Infections ◽  
Lymnaeid Snail ◽  
Important Intermediate

AbstractExperimental infections of three EgyptianPseudosuccinea columellapopulations with sympatric miracidia ofFasciolasp., coming from cattle- or sheep-collected eggs, were carried out to determine the capacity of this lymnaeid to support larval development of the parasite. Using microsatellite markers, the isolates of Egyptian miracidia were identified asFasciola hepatica. Apart from being independent of snail origin, prevalences ranging from 60.4 to 75.5% in snails infected with five miracidia ofF. hepaticawere significantly higher than values of 30.4 to 42.2% in snails with bi-miracidial infections. The number of metacercariae ranged from 243 to 472 per cercarial-shedding snail and was independent of snail origin, parasite origin and miracidial dose used for infection. IfP. columellawas subjected to two successive bi-miracidial infections withF. hepatica, prevalence of infection was 63.3%, with a mean of 311 metacercariae per snail. These values were clearly greater than those already reported forRadix natalensisinfected with the same parasite and the same protocol. Successful experimental infection ofP. columellawithF. hepaticasuggests that this lymnaeid snail is an important intermediate host for the transmission of fascioliasis in Egypt.

scholarly journals Experimental Infection of Pregnant Ewes withChlamydia pecorum

1998 ◽  
Vol 66 (6) ◽  
pp. 2818-2821 ◽  
Author(s):  
Helen L. Philips ◽  
Michael J. Clarkson
Keyword(s):  
Experimental Infection ◽  
Complement Fixation Test ◽  
Complement Fixation ◽  
Fasciola Hepatica ◽  
Oral Infection ◽  
Serological Evidence ◽  
Tissue Invasion ◽  
Chlamydia Pecorum ◽  
Vaginal Swabs ◽  
Gestation Time

ABSTRACT Pregnant ewes were infected in midpregnancy with three isolates ofChlamydia pecorum derived from the feces of healthy lambs from three different farms. Oral infection, alone or together withFasciola hepatica, did not result in tissue invasion, since all placental and fecal samples were negative for chlamydiae. Intravenous infection resulted in placental infection in 16 of 18 ewes in that chlamydiae were cultured from placentas or vaginal swabs. Two ewes bore dead lambs after a shortened gestation time. The chlamydiae isolated were all C. pecorum. There were no significant differences between the weights of the lambs from the infected groups and those from uninfected control ewes. Most ewes showed no serological evidence of infection by the complement fixation test; therefore, it is unlikely that the enteric subtype ofC. pecorum is responsible for the cross-reactions sometimes seen in flocks being tested for C. psittaciinfection.

Experimental Infection of Lymnaea glabra and L. truncatula by Fasciola hepatica

1984 ◽  
Vol 70 (5) ◽  
pp. 847 ◽  
Author(s):  
Dominique Bouix-Busson ◽  
Daniel Rondelaud ◽  
Dominique Barthe
Keyword(s):  
Experimental Infection ◽  
Fasciola Hepatica

Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep

2010 ◽  
Vol 173 (3-4) ◽  
pp. 228-235 ◽  
Author(s):  
Jennifer Keiser ◽  
Carla Kirchhofer ◽  
Manuel Haschke ◽  
Jörg Huwyler ◽  
Yuxiang Dong ◽  
...  
Keyword(s):  
Experimental Infection ◽  
Fasciola Hepatica
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