Susceptibility of Peromyscus leucopus and Mus musculus to Infection with Baylisascaris procyonis

1997 ◽  
Vol 83 (6) ◽  
pp. 1104 ◽  
Author(s):  
Claudia H. Sheppard ◽  
Kevin R. Kazacos
Keyword(s):  
Mus Musculus ◽  
Peromyscus Leucopus ◽  
Baylisascaris Procyonis

scholarly journals Bitter avoidance in guinea pigs (Cavia porcellus) and mice (Mus musculus and Peromyscus leucopus).

2010 ◽  
Vol 124 (4) ◽  
pp. 455-459 ◽  
Author(s):  
Kristin L. Field ◽  
Gary K. Beauchamp ◽  
Bruce A. Kimball ◽  
Julie A. Mennella ◽  
Alexander A. Bachmanov
Keyword(s):  
Mus Musculus ◽  
Guinea Pigs ◽  
Peromyscus Leucopus ◽  
Cavia Porcellus

scholarly journals An Infection-Tolerant Mammalian Reservoir for Several Zoonotic Agents Broadly Counters the Inflammatory Effects of Endotoxin

mBio ◽  
2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Gabriela Balderrama-Gutierrez ◽  
Ana Milovic ◽  
Vanessa J. Cook ◽  
M. Nurul Islam ◽  
Youwen Zhang ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Mus Musculus ◽  
Peromyscus Leucopus ◽  
Differential Expression Analysis ◽  
Rna Seq ◽  
Content Type ◽  
Reactive Protein ◽  
Arginase 1 ◽  
M1 Macrophage ◽  
Infection Resistance

ABSTRACT Animals that are competent reservoirs of zoonotic pathogens commonly suffer little morbidity from the infections. To investigate mechanisms of this tolerance of infection, we used single-dose lipopolysaccharide (LPS) as an experimental model of inflammation and compared the responses of two rodents: Peromyscus leucopus, the white-footed deermouse and reservoir for the agents of Lyme disease and other zoonoses, and the house mouse Mus musculus. Four hours after injection with LPS or saline, blood, spleen, and liver samples were collected and subjected to transcriptome sequencing (RNA-seq), metabolomics, and specific reverse transcriptase quantitative PCR (RT-qPCR). Differential expression analysis was at the gene, pathway, and network levels. LPS-treated deermice showed signs of sickness similar to those of exposed mice and had similar increases in corticosterone levels and expression of interleukin 6 (IL-6), tumor necrosis factor, IL-1β, and C-reactive protein. By network analysis, the M. musculus response to LPS was characterized as cytokine associated, while the P. leucopus response was dominated by neutrophil activity terms. In addition, dichotomies in the expression levels of arginase 1 and nitric oxide synthase 2 and of IL-10 and IL-12 were consistent with type M1 macrophage responses in mice and type M2 responses in deermice. Analysis of metabolites in plasma and RNA in organs revealed species differences in tryptophan metabolism. Two genes in particular signified the different phenotypes of deermice and mice: the Slpi and Ibsp genes. Key RNA-seq findings for P. leucopus were replicated in older animals, in a systemic bacterial infection, and with cultivated fibroblasts. The findings indicate that P. leucopus possesses several adaptive traits to moderate inflammation in its balancing of infection resistance and tolerance. IMPORTANCE Animals that are natural carriers of pathogens that cause human diseases commonly manifest little or no sickness as a consequence of infection. Examples include the deermouse, Peromyscus leucopus, which is a reservoir for Lyme disease and several other disease agents in North America, and some types of bats, which are carriers of viruses with pathogenicity for humans. Mechanisms of this phenomenon of infection tolerance and entailed trade-off costs are poorly understood. Using a single injection of lipopolysaccharide (LPS) endotoxin as a proxy for infection, we found that deermice differed from the mouse (Mus musculus) in responses to LPS in several diverse pathways, including innate immunity, oxidative stress, and metabolism. Features distinguishing the deermice cumulatively would moderate downstream ill effects of LPS. Insights gained from the P. leucopus model in the laboratory have implications for studying infection tolerance in other important reservoir species, including bats and other types of wildlife.

scholarly journals Effect of Blarina brevicauda on trap response of Microtus pennsylvanicus

1982 ◽  
Vol 60 (3) ◽  
pp. 438-442 ◽  
Author(s):  
Rudy Boonstra ◽  
F. Helen Rodd ◽  
David J. Carleton
Keyword(s):  
Mus Musculus ◽  
Peromyscus Leucopus ◽  
Microtus Pennsylvanicus ◽  
Rodent Species ◽  
Lower Probability ◽  
Blarina Brevicauda

The response of Microtus pennsylvanicus to traps with or without various prior occupants is described. Microtus were most frequently captured in traps previously visited by Microtus, but they showed a significant avoidance of traps previously visited by Blarina brevicauda. However, the probability of entry into such traps was no lower than into traps previously visited by other rodent species (Mus musculus, Peromyscus leucopus, or Zapus hudsonicus). There was an even lower probability of entry into traps which were previously empty. Blarina had a significantly higher probability of entering traps previously capturing Blarina than traps previously capturing Microtus or no one. We conclude that this evidence gives no support for the hypothesis that Blarina is a significant predator of Microtus pennsylvanicus.

Zwei Fallberichte einer disseminierten Toxoplasmose

2012 ◽  
Vol 40 (01) ◽  
pp. 64-69
Author(s):  
C. Kiesow ◽  
C. Ellenberger ◽  
B. Stief
Keyword(s):  
Mus Musculus ◽  
Ailurus Fulgens

ZusammenfassungEs werden die Fälle einer disseminierten letalen Toxoplasmose bei einer Farbmaus (Mus musculus) und einem Roten Panda (Ailurus fulgens) vorgestellt. Es handelte sich um eine als Haustier gehaltene Farbmaus und einen Roten Panda aus einem sächsischen zoologischen Garten. Die pathologische Untersuchung ergab bei beiden Tieren eine systemische Toxoplasmeninfektion. Eine hochgradige nekrotisierende Hepatitis stellte in beiden Fällen den histologischen Hauptbefund dar. Parasitenzysten fanden sich massenhaft in der Leber, in mäßiger Zahl im Gehirn und in geringer Zahl in anderen Organen. Mittels PAS-Reaktion waren diese Zysten bei der Farbmaus kaum darstellbar, beim Roten Panda dagegen sehr deutlich. PCR bzw. Immunhistologie bestätigten die Diagnose.

Effect of Thyroxinehormone on Blood Parameters of Pregnant and Non-Pregnant Females Mus musculus

2016 ◽  
Vol 29 (1) ◽  
pp. 172-184
Author(s):  
Sami J. Al-Maliki ◽  
Ali A. A. Al-Ali ◽  
Salma S. Abbas
Keyword(s):  
Mus Musculus ◽  
Blood Parameters ◽  
Pregnant Females

Analisis Kuantitatif Sel Purkinje Cerebellum Mencit (Mus musculus L.) setelah Induksi Ochratoksin A Selama Periode Organogenesis

2011 ◽  
Vol 16 (2) ◽  
Author(s):  
Arum Setiawan ◽  
Mammed Sagi ◽  
Widya Asmara ◽  
Istriyati Istriyati
Keyword(s):  
Mus Musculus

Penelitian ini bertujuan mengetahui jumlah sel Purkinje cerebellum anak mencit umur 21 hari (pascasapih) setelah induksi Ochratoksin A selama periode organogenesis. Tiga puluh ekor mencit bunting dibagi secara acak menjadi 5 kelompok perlakuan dengan masing-masing 6 ulangan. Ochratoksin A dilarutkan dalam Sodium Bicarbonat, diberikan secara oral pada saat kebuntingan hari ke 7 sampai hari ke -14. Dosis perlakuan Ochratoksin A adalah 0,5 ; 1,0; 1,5 mg/kg bb dan sebagai kontrol tidak diberi perlakuan, serta kontrol placebo diberi perlakuan pelarut Sodium Bicarbonat. Induk mencit dipelihara sampai melahirkan. Pada umur ke 21 hari (pascasapih), anak mencit dikorbankan dan diambil bagian otaknya. Otak mencit selanjutnya dipreparasi dengan metode parafin dan pewarnaan menggunakan pewarnaan Haematoksilin Eosin. Data jumlah sel Purkinje dianalisis dengan Anava Satu Arah dan dilanjutkan dengan uji DMRT untuk mengetahui beda nyata antar perlakuan. Hasil penelitian menunjukkan bahwa Ochratoksin A yang diberikan pada mencit bunting selama periode organogenesis menyebabkan terhambatnya pertumbuhan jumlah sel Purkinje mencit perlakuan yang ditandai dengan semakin menurunnya jumlah sel Purkinje dibandingkan dengan kontrol dan kontrol placebo.

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