Commercially Available, Edible Snails Otala lactea (Muller) and Helix aperta (Born) as Laboratory Hosts of Angiostrongylus cantonensis

1977 ◽  
Vol 63 (6) ◽  
pp. 1132
Author(s):  
Karel Jindrak ◽  
Malti G. Mansukhani ◽  
Andrew Freiberg
Keyword(s):  
Angiostrongylus Cantonensis ◽  
Otala Lactea

Activación y biosíntesis intratecal de C3c en niños con meningoencefalitis eosinofílica por Angiostrongylus cantonensis

2009 ◽  
Vol 48 (12) ◽  
pp. 632
Author(s):  
Bárbara Padilla Docal ◽  
Alberto Juan Dorta Contreras ◽  
Raisa Bu-Coifiú Fanego
Keyword(s):  
Angiostrongylus Cantonensis

scholarly journals TNF-α Triggers RIP1/FADD/Caspase-8-Mediated Apoptosis of Astrocytes and RIP3/MLKL-Mediated Necroptosis of Neurons Induced by Angiostrongylus cantonensis Infection

2021 ◽  
Author(s):  
Hongli Zhou ◽  
Minyu Zhou ◽  
Yue Hu ◽  
Yanin Limpanon ◽  
Yubin Ma ◽  
...  
Keyword(s):  
Cell Death ◽  
Enrichment Analysis ◽  
Angiostrongylus Cantonensis ◽  
Gene Set Enrichment Analysis ◽  
Caspase 8 ◽  
Cns Injury ◽  
Vitro Assay ◽  
Tnf Α

AbstractAngiostrongylus cantonensis (AC) can cause severe eosinophilic meningitis or encephalitis in non-permissive hosts accompanied by apoptosis and necroptosis of brain cells. However, the explicit underlying molecular basis of apoptosis and necroptosis upon AC infection has not yet been elucidated. To determine the specific pathways of apoptosis and necroptosis upon AC infection, gene set enrichment analysis (GSEA) and protein–protein interaction (PPI) analysis for gene expression microarray (accession number: GSE159486) of mouse brain infected by AC revealed that TNF-α likely played a central role in the apoptosis and necroptosis in the context of AC infection, which was further confirmed via an in vivo rescue assay after treating with TNF-α inhibitor. The signalling axes involved in apoptosis and necroptosis were investigated via immunoprecipitation and immunoblotting. Immunofluorescence was used to identify the specific cells that underwent apoptosis or necroptosis. The results showed that TNF-α induced apoptosis of astrocytes through the RIP1/FADD/Caspase-8 axis and induced necroptosis of neurons by the RIP3/MLKL signalling pathway. In addition, in vitro assay revealed that TNF-α secretion by microglia increased upon LSA stimulation and caused necroptosis of neurons. The present study provided the first evidence that TNF-α was secreted by microglia stimulated by AC infection, which caused cell death via parallel pathways of astrocyte apoptosis (mediated by the RIP1/FADD/caspase-8 axis) and neuron necroptosis (driven by the RIP3/MLKL complex). Our research comprehensively elucidated the mechanism of cell death after AC infection and provided new insight into targeting TNF-α signalling as a therapeutic strategy for CNS injury.

Cryptic lineage diversity in the zoonotic pathogen Angiostrongylus cantonensis

2017 ◽  
Vol 107 ◽  
pp. 404-414 ◽  
Author(s):  
Sirilak Dusitsittipon ◽  
Charles D. Criscione ◽  
Serge Morand ◽  
Chalit Komalamisra ◽  
Urusa Thaenkham
Keyword(s):  
Angiostrongylus Cantonensis ◽  
Zoonotic Pathogen ◽  
Cryptic Lineage ◽  
Lineage Diversity

scholarly journals Angiostrongylus cantonensis (Nematode: Metastrongiloidea): In Vitro Cultivation of Infective Third-Stage Larvae to Fourth-Stage Larvae

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72084 ◽  
Author(s):  
Rong-Jyh Lin ◽  
Jie-Wen He ◽  
Li-Yu Chung ◽  
June-Der Lee ◽  
Jiun-Jye Wang ◽  
...  
Keyword(s):  
Angiostrongylus Cantonensis ◽  
In Vitro Cultivation ◽  
Fourth Stage ◽  
Third Stage

Angiostrongylus cantonensis in urban populations of terrestrial gastropods and rats in an impoverished region of Brazil

Parasitology ◽  
2021 ◽  
pp. 1-34
Author(s):  
Fábio Neves Souza ◽  
Maísa Aguiar Santos ◽  
Daniele Almeida Alves ◽  
Leyva Cecília Vieira de Melo ◽  
Dan Jessé Gonçalves da Mota ◽  
...  
Keyword(s):  
Angiostrongylus Cantonensis ◽  
Urban Populations ◽  
Terrestrial Gastropods
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