Infection of the Jird, Meriones unguiculatus, with the Filarial Worm, Dipetalonema viteae: Central Nervous System Invasion and Pathology

1974 ◽  
Vol 60 (1) ◽  
pp. 138 ◽  
Author(s):  
Paul P. Weinstein ◽  
Benjamin Highman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Meriones Unguiculatus ◽  
Filarial Worm ◽  
Central Nervous System Invasion ◽  
Dipetalonema Viteae

scholarly journals Persistent cognitive impairment associated with cerebrospinal fluid anti-SARS-CoV-2 antibodies six months after mild COVID-19

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Max Borsche ◽  
Dirk Reichel ◽  
Anja Fellbrich ◽  
Anne S. Lixenfeld ◽  
Johann Rahmöller ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Cognitive Impairment ◽  
Female Patient ◽  
Acute Phase ◽  
Neuropsychological Testing ◽  
Important Challenge ◽  
Central Nervous System Invasion

AbstractNeurological long-term sequelae are increasingly considered an important challenge in the recent COVID-19 pandemic. However, most evidence for neurological symptoms after SARS-CoV-2 infection and central nervous system invasion of the virus stems from individuals severely affected in the acute phase of the disease. Here, we report long-lasting cognitive impairment along with persistent cerebrospinal fluid anti-SARS-CoV-2 antibodies in a female patient with unremarkable standard examination 6 months after mild COVID-19, supporting the implementation of neuropsychological testing and specific cerebrospinal fluid investigation also in patients with a relatively mild acute disease phase.

Autotaxin and soluble IL-2 receptor concentrations in cerebrospinal fluids are useful for the diagnosis of central nervous system invasion caused by haematological malignancies

2019 ◽  
Vol 56 (2) ◽  
pp. 240-246 ◽  
Author(s):  
Takuya Shimura ◽  
Makoto Kurano ◽  
Yoshifumi Morita ◽  
Naoyuki Yoshikawa ◽  
Masako Nishikawa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Diagnostic Imaging ◽  
Haematological Malignancies ◽  
Serum Concentrations ◽  
Receptor Concentration ◽  
The Central Nervous System ◽  
Central Nervous System Invasion ◽  
Strong Ability

Background Invasion of the central nervous system by haematological malignancies is diagnosed by cytological analyses of cerebrospinal fluid or diagnostic imaging, while quantitative biomarkers for central nervous system invasion are not available and needed to be developed. Methods In this study, we measured the concentrations of autotaxin and soluble IL-2 receptor in cerebrospinal fluid and evaluated their usefulness as biomarkers for central nervous system invasion. Results We observed that both the autotaxin and soluble IL-2 receptor concentrations in cerebrospinal fluid were higher in subjects with central nervous system invasion than in those without, and the cerebrospinal fluid concentrations were independent from the serum concentrations of these biomarkers. ROC analyses revealed that the soluble IL-2 receptor concentration in cerebrospinal fluid was a strong discriminator of central nervous system invasion in subjects with haematological malignancies, while the autotaxin concentration in cerebrospinal fluid also had a strong ability to discriminate central nervous system invasion when the subjects were limited to those with lymphoma. The combined measurement of autotaxin and soluble IL-2 receptor in cerebrospinal fluid improved the sensitivity without notably reducing the specificity for central nervous system invasion in subjects with lymphoma when central nervous system invasion was diagnosed in cases where either value was beyond the respective cut-off value. Conclusion These results suggest the possible usefulness of soluble IL-2 receptor and autotaxin concentrations in cerebrospinal fluid for the diagnosis of central nervous system invasion.

Indications for, Contraindications to, and Interruption of Craniofacial Procedures

1997 ◽  
Vol 106 (11) ◽  
pp. 927-933 ◽  
Author(s):  
Claudio R. Cernea ◽  
Gilberto V. Teixeira ◽  
Eduardo A. S. Vellutini ◽  
Luiz R. Medina dos Santos ◽  
Mário G. Siqueira
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Skull Base ◽  
Malignant Tumors ◽  
Purulent Discharge ◽  
Benign Tumors ◽  
Histologic Diagnosis ◽  
Lateral Skull Base ◽  
Central Nervous System Invasion ◽  
Orbital Invasion

In spite of increasing experience with skull base surgery, some of the guidelines for indications for operations may vary according to the institution. One-hundred two patients underwent craniofacial oncologic resections at our institution from 1982 to 1995. A retrospective analysis of the indications for and contraindications to these procedures was undertaken. The main indications for malignant tumors were skin lesions with direct invasion of the anterior or lateral skull base (69%) and nasal-paranasal sinus tumors (21%). The main indications for benign tumors were glomus lesions (26%), menigiomas (22%), and fibro-osseous lesions of the anterior skull base (19%). The main contraindications were extensive invasion of the central nervous system, invasion of the cavernous sinus and/or internal carotid artery by aggressive malignancies, and bilateral orbital invasion in a nonblind patient. Also, 6 patients had their procedures interrupted during craniotomy for several reasons — extensive central nervous system invasion (2 cases), bilateral orbital invasion (1), lack of brain retraction (1), lack of histologic diagnosis during the operation (1), and purulent discharge at the frontal sinus (1). Craniofacial oncologic operations are extensive surgical procedures that have to be properly indicated in order to obtain low levels of morbidity and mortality. The selection of cases is of paramount importance. In some instances, it seems advisable even to interrupt these operations in the first phase.

Growth of central nervous system auditory and visual nuclei in the postnatal gerbil (Meriones unguiculatus)

1994 ◽  
Vol 346 (2) ◽  
pp. 289-305 ◽  
Author(s):  
R. Rübsamen ◽  
M. Gutowski ◽  
J. Langkau ◽  
G. J. Dörrscheidt
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Meriones Unguiculatus

scholarly journals Urease Expression by Cryptococcus neoformans Promotes Microvascular Sequestration, Thereby Enhancing Central Nervous System Invasion

2004 ◽  
Vol 164 (5) ◽  
pp. 1761-1771 ◽  
Author(s):  
Michal A. Olszewski ◽  
Mairi C. Noverr ◽  
Gwo-Hsiao Chen ◽  
Galen B. Toews ◽  
Gary M. Cox ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cryptococcus Neoformans ◽  
Central Nervous System Invasion

scholarly journals Early activation of the host complement system is required to restrict central nervous system invasion and limit neuropathology during Venezuelan equine encephalitis virus infection

2012 ◽  
Vol 93 (4) ◽  
pp. 797-806 ◽  
Author(s):  
Christopher B. Brooke ◽  
Alexandra Schäfer ◽  
Glenn K. Matsushima ◽  
Laura J. White ◽  
Robert E. Johnston
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Complement System ◽  
Rna Virus ◽  
Venezuelan Equine Encephalitis Virus ◽  
Encephalitis Virus ◽  
Venezuelan Equine Encephalitis ◽  
Equine Encephalitis Virus ◽  
Central Nervous System Invasion ◽  
Immunocompetent Mice

Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne RNA virus of the genus Alphavirus, family Togaviridae, that is responsible for sporadic outbreaks in human and equid populations in Central and South America. In order to ascertain the role that complement plays in resolving VEEV-induced disease, complement-deficient C3−/− mice were infected with a VEEV mutant (V3533) that caused mild, transient disease in immunocompetent mice. In the absence of a functional complement system, peripheral inoculation with V3533 induced much more severe encephalitis. This enhanced pathology was associated with a delay in clearance of infectious virus from the serum and more rapid invasion of the central nervous system in C3−/− mice. If V3533 was inoculated directly into the brain, however, disease outcome in C3−/− and wild-type mice was identical. These findings indicate that complement-dependent enhancement of peripheral virus clearance is critical for protecting against the development of severe VEEV-induced encephalitis.

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