Hymenolepis microstoma: Early Histopathologic Changes in Mouse Bile Duct

1970 ◽  
Vol 89 (2) ◽  
pp. 274 ◽  
Author(s):  
Carolyn R. Sanborn ◽  
William C. Marquardt ◽  
Donald W. Duszynski
Keyword(s):  
Bile Duct ◽  
Histopathologic Changes ◽  
Hymenolepis Microstoma

The effect of oxyclozanide on Hymenolepis microstoma and H. diminuta

Parasitology ◽  
1973 ◽  
Vol 66 (2) ◽  
pp. 355-365 ◽  
Author(s):  
C. A. Hopkins ◽  
P. M. Grant ◽  
Helen Stallard
Keyword(s):  
Immune Response ◽  
Small Intestine ◽  
Single Dose ◽  
Bile Duct ◽  
Dose Level ◽  
Harmful Effect ◽  
Maximum Level ◽  
Adult Size ◽  
Hymenolepis Microstoma

The effect of oxyclozanide (2,2′-dihydroxy-3,3′,5,5′,6-pentachlorobenzanilide) on Hymenolepis microstoma in the bile duct of mice, and H. diminuta in the small intestine of mice and rats was measured. Oxyclozanide at doses as low as 4mg/kg removed 13-day-old H. diminuta and caused no obvious harmful effect to the rat host up to the maximum level (256 mg/kg) tested. Worms were displaced and degenerating within 1 h. Results in mice were more difficult to assess because of the immune response, but similar total amounts of oxyclozanide caused destrobilation and loss of 7-day-old H. diminuta. Oxyclozanide was less effective against 21-day-old H. microstoma attached in the bile duct. Approximately half the strobila was lost following dosing at 5 mg/kg and progressively greater amounts as the dose level was increased. At 50 mg/kg worm loss commenced but even at 150 mg/kg 25 % of worms survived. The time taken to regrow to the original adult size varied but was complete within 7–9 days at levels up to 25 mg/kg. Double dosing at 5-day intervals did not enhance the effect of a single dose. The apparent existence of a sensitivity gradient down the strobila in H. microstoma is discussed.

Intranuclear bodies in the tissues of the scolex of the cestode Hymenolepis microstoma

1984 ◽  
Vol 62 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Rodney A. Webb
Keyword(s):  
Electron Microscope ◽  
Bile Duct ◽  
Lattice Structure ◽  
Tegumental Cell ◽  
Hymenolepis Microstoma

Intranuclear bodies were observed in the tissues of the scolex of Hymenolepis microstoma where they were most frequent and well developed in the rostellar tegumental cell bodies. The intranuclear bodies in the electron microscope appeared as bundles of fibrillae oriented in a loose lattice structure, set in a featureless lucent nucleoplasm. The fibrillae were ~8 nm in diameter with a longitudinal periodicity of ~6 nm. These bodies, restricted almost entirely to the scolex, were observed only after the scolex had migrated into the bile duct. The correlation of these bodies with possibly viral, pathological, and hypermetabolic states is discussed.

Hymenolepis microstoma: a change in susceptibility to resistance with increasing age of the parasite

Parasitology ◽  
1977 ◽  
Vol 75 (2) ◽  
pp. 241-249 ◽  
Author(s):  
R. J. Howard
Keyword(s):  
Bile Duct ◽  
Primary Infection ◽  
Secondary Infection ◽  
Similar Rate ◽  
Rate Of Growth ◽  
Secondary Infections ◽  
Hymenolepis Microstoma

Hymenolepis microstoma from secondary infections in mice were found to grow initially more slowly than H. microstoma from primary infections. Eventually a similar rate of growth was attained by both kinds of worm. After transplantation, young worms (≤4 days old) grew more slowly in previously infected than in naive mice. In contrast, 10-day-old worms grew equally well in naive or resistant mice. The administration of cortisone to mice during a secondary infection of H. microstoma inhibited the stunting of growth in young worms which were able to grow as well as those in a primary infection. The effects of the cortisone persisted for less than 4 days. Worms in a secondary infection given 4days after cortisone treatment were stunted in growth. These experiments suggest that the susceptibility of the worms to the resistance of the mouse applies to the first 4 days within the host. The loss or reduction of this susceptibility might be associated with the worms' entry into the bile duct which occurs 3–4 days after infection.

Effects of cyclophosphamide and dexamethasone on mast cell populations in Hymenolepis microstoma-infected mice

Parasitology ◽  
1990 ◽  
Vol 100 (2) ◽  
pp. 337-343 ◽  
Author(s):  
M. Novak ◽  
L. G. Buchannan ◽  
H. Howlader
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Bile Duct ◽  
The Other ◽  
Cell Populations ◽  
Other Hand ◽  
Hymenolepis Microstoma

SUMMARYAntineoplastic cyclophosphamide (CY) significantly reduced the survival and the weight of Hymenolepis microstoma in mice. Corticosteroid dexamethasone (DEX), on the other hand, did not influence the worm survival and the worms in DEX-treated mice became significantly heavier. Both immunosuppressants abolished H. microstoma-induced bile duct hypertrophy and submucous enteritis and lowered the number of mast cells (MC) in these regions. CY appeared to be more effective in depleting the bile duct MC whereas DEX seemed to affect more the duodenal MC population.

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