Phase I and II Archaeological Investigations of Old Baltimore Pike from Four Seasons Parkway to the Christiana Bypass, New Castle County, Delaware. Wade P. Catts, Jay Hodny, and Jay F. Custer. University of Delaware, Newark, 1989. xi + 429 pp., figures, plates, tables, references, appendix. Free.

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Osteosarcoma (OS) is a rare condition with very poor prognosis in a metastatic setting. Basic research has enabled a better understanding of OS pathogenesis and the discovery of new potential therapeutic targets. Phase I and II clinical trials are already ongoing, with some promising results for these patients. This article reviews OS pathogenesis and new potential therapeutic targets.


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