A Recurrent Outbreak of Nosocomial Legionnaires' Disease Detected by Urinary Antigen Testing: Evidence for Long-Term Colonization of a Hospital Plumbing System

1998 ◽  
Vol 19 (12) ◽  
pp. 905-910 ◽  
Author(s):  
Lisa A. Lepine ◽  
Daniel B. Jernigan ◽  
Jay C. Butler ◽  
Janet M. Pruckler ◽  
Robert F. Benson ◽  
...  
Keyword(s):  
Plumbing System ◽  
Urinary Antigen ◽  
Urinary Antigen Testing ◽  
Legionnaires Disease ◽  
Antigen Testing

A Recurrent Outbreak of Nosocomial Legionnaires' Disease Detected by Urinary Antigen Testing: Evidence for Long-Term Colonization of a Hospital Plumbing System

1998 ◽  
Vol 19 (12) ◽  
pp. 905-910 ◽  
Author(s):  
Lisa A. Lepine ◽  
Daniel B. Jernigan ◽  
Jay C. Butler ◽  
Janet M. Pruckler ◽  
Robert F. Benson ◽  
...  
Keyword(s):  
Plumbing System ◽  
Urinary Antigen ◽  
Urinary Antigen Testing ◽  
Legionnaires Disease ◽  
Antigen Testing

A Recurrent Outbreak of Nosocomial Legionnaires' Disease Detected by Urinary Antigen Testing Evidence for Long-Term Colonization of a Hospital Plumbing System

1998 ◽  
Vol 19 (12) ◽  
pp. 905-910
Author(s):  
Lisa A. Lepine ◽  
Daniel B. Jernigan ◽  
Jay C. Butler ◽  
Janet M. Pruckler ◽  
Robert F. Benson ◽  
...  
Keyword(s):  
Plumbing System ◽  
Urinary Antigen ◽  
Urinary Antigen Testing ◽  
Legionnaires Disease ◽  
Antigen Testing

scholarly journals Legionella pneumonia presenting with bilateral flank pain, hyponatraemia and acute renal failure

2013 ◽  
Vol 5 (6) ◽  
pp. 96
Author(s):  
Celia Birkin ◽  
Chandra Shekhar Biyani ◽  
Anthony J. Browning
Keyword(s):  
Gastrointestinal Symptoms ◽  
Community Acquired Pneumonia ◽  
Flank Pain ◽  
High Fever ◽  
Urinary Antigen ◽  
Legionella Pneumonia ◽  
Urinary Antigen Testing ◽  
Legionella Species ◽  
Legionnaires Disease ◽  
Antigen Testing

Legionnaires’ disease (LD) is an often overlooked but a possiblecause of sporadic community acquired pneumonia. High fever,cough and gastrointestinal symptoms are non-specific symptoms.Hyponatremia is more common in LD than pneumonia linkedwith other causes. A definitive diagnosis is usually confirmed byculture, urinary antigen testing for Legionella species. Macolideor quinolone antibiotic is the treatment of choice. We describe acase of Legionella pneumonia presenting with high fever, bilateralflank pain and oliguria. It is important for clinicians to be awareof this diagnosis when managing patients with flank pain. Thecase highlights the problems in differentiating LD from renal colicand the importance of proper history, physical examination withlaboratory tests for appropriate management.

scholarly journals Environmental Cultures and Hospital-Acquired Legionnaires' Disease: A 5-Year Prospective Study in 20 Hospitals in Catalonia, Spain

2004 ◽  
Vol 25 (12) ◽  
pp. 1072-1076 ◽  
Author(s):  
Miquel Sabrià ◽  
Josep M. Mòdol ◽  
Marian Garcia-Nuñez ◽  
Esteban Reynaga ◽  
Maria L. Pedro-Botet ◽  
...  
Keyword(s):  
Prospective Study ◽  
Potable Water ◽  
Environmental Study ◽  
Urinary Antigen ◽  
Hospital Acquired Pneumonia ◽  
Urinary Antigen Testing ◽  
Legionnaires Disease ◽  
Hospital Acquired ◽  
Antigen Testing

AbstractObjective:To determine whether environmental cultures forLegionellaincrease the index of suspicion for legionnaires' disease (LD).Design:Five-year prospective study.Setting:Twenty hospitals in Catalonia, Spain.Methods:From 1994 to 1996, the potable water systems of 20 hospitals in Catalonia were tested forLegionella, Cases of hospital-acquired LD and availability of an “in-house”Legionellatest in the previous 4 years were assessed. After the hospitals were informed of the results of their water cultures, a prospective 5-year-study was conducted focusing on the detection of new cases of nosocomial legionellosis and the availability and use of Legionella testing.Results:Before environmental cultures were started, only one hospital had conducted active surveillance of hospital-acquired pneumonia and usedLegionellatests includingLegionellaurinary antigen in all pneumonia cases. Only one other hospital had used the latter test at all. In six hospitals,Legionellatests had been completely unavailable. Cases of nosocomial LD had been diagnosed in the previous 4 years in only two hospitals. During prospective surveillance, 12 hospitals (60%) usedLegionellaurinary antigen testing in house and 11 (55%) found cases of nosocomial legionellosis, representing 64.7% (11 of 17) of those with positive water cultures. Hospitals with negative water cultures did not find nosocomial LD.Conclusions:The environmental study increased the index of suspicion for nosocomial LD. The number of cases of nosocomial LD increased significantly during the prospective follow-up period, and most hospitals began using theLegionellaurinary antigen test in their laboratories.

scholarly journals Healthcare-associated Legionnaires’ disease: Limitations of surveillance definitions and importance of epidemiologic investigation

2017 ◽  
Vol 18 (6) ◽  
pp. 307-310 ◽  
Author(s):  
Laila M Castellino ◽  
Shantini D Gamage ◽  
Patti V Hoffman ◽  
Stephen M Kralovic ◽  
Mark Holodniy ◽  
...  
Keyword(s):  
Legionella Pneumophila ◽  
Sequence Type ◽  
Significant Morbidity ◽  
Urinary Antigen ◽  
Epidemiologic Investigation ◽  
Urinary Antigen Testing ◽  
Legionnaires Disease ◽  
Healthcare Associated ◽  
Antigen Testing

Healthcare-associated Legionnaires’ disease (HCA LD) causes significant morbidity and mortality, with varying guidance on prevention. We describe the evaluation of a case of possible HCA LD and note the pitfalls of relying solely on an epidemiologic definition for association of a case with a facility. Our detailed investigation led to the identification of a new Legionella pneumophila serogroup 1 sequence type, confirmed a healthcare association and helped build the framework for our ongoing preventive efforts. Our experience highlights the role of routine environmental cultures in the assessment of risk for a given facility. As clinicians increasingly rely on urinary antigen testing for the detection of L. pneumophila, our investigation emphasises the importance of clinical cultures in an epidemiologic investigation.

scholarly journals Environmental Cultures and Hospital-Acquired Legionnaires' Disease: A 5-Year Prospective Study in 20 Hospitals in Catalonia, Spain

2004 ◽  
Vol 25 (12) ◽  
pp. 1072-1076 ◽  
Author(s):  
Miquel Sabrià ◽  
Josep M. Mòdol ◽  
Marian Garcia-Nuñez ◽  
Esteban Reynaga ◽  
Maria L. Pedro-Botet ◽  
...  
Keyword(s):  
Prospective Study ◽  
Potable Water ◽  
Environmental Study ◽  
Urinary Antigen ◽  
Hospital Acquired Pneumonia ◽  
Urinary Antigen Testing ◽  
Legionnaires Disease ◽  
Hospital Acquired ◽  
Antigen Testing

AbstractObjective:To determine whether environmental cultures forLegionellaincrease the index of suspicion for legionnaires' disease (LD).Design:Five-year prospective study.Setting:Twenty hospitals in Catalonia, Spain.Methods:From 1994 to 1996, the potable water systems of 20 hospitals in Catalonia were tested forLegionella, Cases of hospital-acquired LD and availability of an “in-house”Legionellatest in the previous 4 years were assessed. After the hospitals were informed of the results of their water cultures, a prospective 5-year-study was conducted focusing on the detection of new cases of nosocomial legionellosis and the availability and use of Legionella testing.Results:Before environmental cultures were started, only one hospital had conducted active surveillance of hospital-acquired pneumonia and usedLegionellatests includingLegionellaurinary antigen in all pneumonia cases. Only one other hospital had used the latter test at all. In six hospitals,Legionellatests had been completely unavailable. Cases of nosocomial LD had been diagnosed in the previous 4 years in only two hospitals. During prospective surveillance, 12 hospitals (60%) usedLegionellaurinary antigen testing in house and 11 (55%) found cases of nosocomial legionellosis, representing 64.7% (11 of 17) of those with positive water cultures. Hospitals with negative water cultures did not find nosocomial LD.Conclusions:The environmental study increased the index of suspicion for nosocomial LD. The number of cases of nosocomial LD increased significantly during the prospective follow-up period, and most hospitals began using theLegionellaurinary antigen test in their laboratories.

Legionella infection in pregnancy: imitator of HELLP syndrome, presenting as acute respiratory failure and septic shock

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Moti Gulersen ◽  
Eran Bornstein
Keyword(s):  
Septic Shock ◽  
Hellp Syndrome ◽  
Laboratory Evaluation ◽  
Maternal Complications ◽  
Elevated Liver Enzymes ◽  
Low Platelet Count ◽  
Urinary Antigen Testing ◽  
Legionnaires Disease ◽  
Antigen Testing ◽  
In Pregnancy

Abstract Background Legionnaires’ disease in pregnancy may cause severe maternal complications. Hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome is a disorder associated with significant maternal and fetal morbidity and mortality. Several medical conditions have been described as imitators of this syndrome, presenting with similar laboratory abnormalities. Case presentation A healthy, multiparous woman presented at 26 weeks’ gestation with fever, headache and general malaise, rapidly progressing to septic shock and respiratory collapse. Laboratory evaluation revealed similar abnormalities to those seen with HELLP syndrome. Emergent cesarean delivery was performed for worsening maternal and fetal conditions. Following delivery, infection with Legionella was diagnosed on urinary antigen testing. Supportive care was administered in the intensive care unit. Conclusion Legionnaires’ disease should be considered in gravidas presenting with rapidly deteriorating respiratory status, septic shock and laboratory abnormalities mimicking HELLP syndrome.

Evaluation of pneumococcal urinary antigen testing for respiratory tract infection investigations

2020 ◽  
Vol 50 (1) ◽  
pp. 57-62 ◽  
Author(s):  
F. Charton ◽  
P.L. Conan ◽  
H. Le Floch ◽  
O. Bylicki ◽  
W. Gaspard ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Urinary Antigen ◽  
Urinary Antigen Testing ◽  
Antigen Testing
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