Archaic Funerary Pattern or Postdepositional Alteration? The Patapatane Burial in the Highlands of South Central Andes

2005 ◽  
Vol 16 (3) ◽  
pp. 329-346 ◽  
Author(s):  
Calogero M. Santoro ◽  
Vivien G. Standen ◽  
Bernardo T. Arriaza ◽  
Tom D. Dillehay
Keyword(s):  
Cervical Vertebrae ◽  
Archaic Period ◽  
The Body ◽  
Northern Chile ◽  
Semiarid Environment ◽  
South Central ◽  
Middle Archaic ◽  
Simultaneous Existence ◽  
Taphonomic Processes

AbstractThe burial found at Patapatane Cave in the highlands of Arica, northern Chile, yielded an incomplete skeleton of a 20-to-23-year-old female, dating to the end of the Middle Archaic period at 5910 ± 90 B.P. The site is located in a semiarid environment on the eastern side of Sierra de Huaylillas at 3800 m. in the hinterland of Arica, northern Chile. We argue that the missing bones, position of the cranium, and breakage of some elements resulted from both postdepositional human intervention and taphonomic processes. The body was laid to rest in a supine position and after it became skeletonized hunters revisited the inhumation and removed some bone elements. However, the other bones present in situ were not displaced and remained in proper anatomical position, with the exception of the cranium, which was placed vertically on top of the cervical vertebrae. The observed breakage of vertebrae, long bones, and skull seems to have been the result of taphonomic, nonanthropogenic, postburial actions. In reporting on the Patapatane burial, Archaic period funerary patterns from western South America are reviewed to support the notion that early hunters and gatherers systematically manipulated their dead through perimortem and postmortem alterations. These included several processes: (1) processes of body reduction and transformation by removal of body sections or removal of bone elements, cremation, and human remains discarded in domestic middens; and (2) processes of artificial preservation of the dead that included roasting, salting, and artificial mummification. In addition, we recognize the simultaneous existence of intact primary burial and that other skeletons were possibly altered accidentally by postdepositional natural or cultural agents.

A Late Archaic Period Burial from the South-Central Andean Coast

1994 ◽  
Vol 5 (3) ◽  
pp. 212-227 ◽  
Author(s):  
Karen Wise ◽  
Niki R. Clark ◽  
Sloan R. Williams
Keyword(s):  
Central Andes ◽  
Archaic Period ◽  
South Coast ◽  
Northern Chile ◽  
Late Archaic ◽  
The South ◽  
The Past ◽  
South Central ◽  
Other Substances ◽  
The Individual

Recent excavations at the Late Archaic Period (ca. 3000-1000 B.C.) site of Kilometer 4 on the far south coast of Peru exposed a burial containing the remains of a 45-year-old male. The individual was buried with an unusual assemblage of artifacts that includes bone and shell implements and elaborate and distinctive cotton textiles, as well as a complex of paraphernalia of which some items were apparently associated with the use of hallucinogenic or other substances. Auditory exostoses indicate that the individual had engaged in maritime activities, including diving. Semi-flexed, single interment burials such as this are well known from the coast of northern Chile, but the use of cotton during the Archaic Period on the coast of the south-central Andes has not been well documented in the past.

Earth-Oven Plant Processing in Archaic Period Economies: An Example from a Semi-Arid Savannah in South-Central North America

1999 ◽  
Vol 64 (4) ◽  
pp. 659-674 ◽  
Author(s):  
Phil Dering
Keyword(s):  
Residential Mobility ◽  
Diet Breadth ◽  
Archaic Period ◽  
Plant Resources ◽  
Early Archaic ◽  
South Central ◽  
River Region ◽  
Middle Archaic ◽  
Earth Ovens ◽  
Earth Oven

AbstractModels of Archaic period economy in the Lower Pecos River region of southwest Texas and Coahuila, Mexico, are based primarily on coprolite, faunal, and macroplant analysis of materials recovered from rockshelters. The models maintain that during the Middle Archaic period residential mobility is reduced and tethered to rockshelters in canyons near water, and diet dominated by the plant resources lechuguilla (Agave lechuguilla), sotol (Dasylirion texanum), and prickly pear (Opuntia spp.). I use archaeobotanical analysis and actualistic studies to determine the contents of earth-oven features, the number of plant food calories produced by ovens, and the quantity of refuse they generate. Considered within the framework of a diet-breadth model, the data demonstrate that return rates and caloric yields for lechuguilla and sotol processed in earth ovens are typical of a broad spectrum, low-return economy. Intensive use of these low-ranked resources indicates periods of subsistence stress beginning in the Early Archaic period and continuing through the Late Archaic. Use of low-ranked, high-cost resources in canyon zones indicates that food and fuel resources were quickly depleted forcing high residential mobility. Depletion of local resources, not the distribution of water sources governed residential mobility.

Scaffolds for Drug Delivery in Tissue Engineering

2008 ◽  
Vol 1 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Vikas V. Gaikwad ◽  
Abasaheb B. Patil ◽  
Madhuri V. Gaikwad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Heart Diseases ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
The Body ◽  
Patient Specific ◽  
In Situ Gel ◽  
Heart Muscle Cells

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth.  Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

scholarly journals Ferromagnetic soft catheter robots for minimally invasive bioprinting

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Cheng Zhou ◽  
Youzhou Yang ◽  
Jiaxin Wang ◽  
Qingyang Wu ◽  
Zhuozhi Gu ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
The Body ◽  
Magnetic Actuation ◽  
Internal Organs ◽  
Planar Surfaces ◽  
Reinforced Polymer ◽  
Direct Fabrication ◽  
Digitally Controlled

AbstractIn vivo bioprinting has recently emerged as a direct fabrication technique to create artificial tissues and medical devices on target sites within the body, enabling advanced clinical strategies. However, existing in vivo bioprinting methods are often limited to applications near the skin or require open surgery for printing on internal organs. Here, we report a ferromagnetic soft catheter robot (FSCR) system capable of in situ computer-controlled bioprinting in a minimally invasive manner based on magnetic actuation. The FSCR is designed by dispersing ferromagnetic particles in a fiber-reinforced polymer matrix. This design results in stable ink extrusion and allows for printing various materials with different rheological properties and functionalities. A superimposed magnetic field drives the FSCR to achieve digitally controlled printing with high accuracy. We demonstrate printing multiple patterns on planar surfaces, and considering the non-planar surface of natural organs, we then develop an in situ printing strategy for curved surfaces and demonstrate minimally invasive in vivo bioprinting of hydrogels in a rat model. Our catheter robot will permit intelligent and minimally invasive bio-fabrication.

scholarly journals Load Measurement of the Cervical Vertebra C7 and the Head of Passengers of a Car While Driving Across Uneven Terrain

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3849
Author(s):  
Martin Svoboda ◽  
Milan Chalupa ◽  
Karel Jelen ◽  
František Lopot ◽  
Petr Kubový ◽  
...  
Keyword(s):  
Cervical Vertebrae ◽  
Vertical Direction ◽  
Cervical Vertebra ◽  
Parietal Bone ◽  
The Body ◽  
Human Organism ◽  
Dynamic Effects ◽  
The Road ◽  
Real Environment ◽  
On The Road

The article deals with the measurement of dynamic effects that are transmitted to the driver (passenger) when driving in a car over obstacles. The measurements were performed in a real environment on a defined track at different driving speeds and different distributions of obstacles on the road. The reaction of the human organism, respectively the load of the cervical vertebrae and the heads of the driver and passenger, was measured. Experimental measurements were performed for different variants of driving conditions on a 28-year-old and healthy man. The measurement’s main objective was to determine the acceleration values of the seats in the vehicle in the vertical movement of parts of the vehicle cabin and to determine the dynamic effects that are transmitted to the driver and passenger in a car when driving over obstacles. The measurements were performed in a real environment on a defined track at various driving speeds and diverse distributions of obstacles on the road. The acceleration values on the vehicle’s axles and the structure of the driver’s and front passenger’s seats, under the buttocks, at the top of the head (Vertex Parietal Bone) and the C7 cervical vertebra (Vertebra Cervicales), were measured. The result of the experiment was to determine the maximum magnitudes of acceleration in the vertical direction on the body of the driver and the passenger of the vehicle when passing a passenger vehicle over obstacles. The analysis of the experiment’s results is the basis for determining the future direction of the research.

Mammary-type Myofibroblastoma with Leiomyomatous Differentiation: A Rare Variant with Potential Pitfalls

2021 ◽  
pp. 106689692110313
Author(s):  
Alexander M. Strait ◽  
Julia A. Bridge ◽  
Anthony J. Iafrate ◽  
Marilyn M. Li ◽  
Feng Xu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Transcriptome Sequencing ◽  
Smooth Muscle Actin ◽  
The Body ◽  
Muscle Actin ◽  
Mature Adipose Tissue ◽  
Spindle Cells ◽  
Whole Transcriptome Sequencing ◽  
Whole Transcriptome

Myofibroblastoma is a rare, benign stromal tumor with a diverse morphologic spectrum. Mammary-type myofibroblastoma (MTMF) is the extra-mammary counterpart of this neoplasm and its occurrence throughout the body has become increasingly recognized. Similar morphologic variations of MTMF have now been described which mirror those seen in the breast. We describe a case of intra-abdominal MTMF composed of short fascicles of eosinophilic spindle cells admixed with mature adipose tissue. The spindle cells stained diffusely positive for CD34, desmin, smooth muscle actin, and h-caldesmon by immunohistochemistry. Concurrent loss of RB1 (13q14) and 13q34 loci were confirmed by fluorescence in situ hybridization whereas anchored multiplex PCR and whole transcriptome sequencing did not reveal any pathognomonic fusions suggesting an alternative diagnosis. To the best of our knowledge this is the first documented case of leiomyomatous variant of MTMF.

Wolf's Syndrome in Twins — Translocation in The Mother

1976 ◽  
Vol 25 (1) ◽  
pp. 267-270 ◽  
Author(s):  
M. Lévy ◽  
B. Noel ◽  
D. Viola
Keyword(s):  
Cervical Vertebrae ◽  
The Body ◽  
Chromosome 4 ◽  
Back Edge ◽  
Intellectual Level ◽  
Mz Twins

A case of MZ twins, both affected by Wolf's syndrome, is described. Their mother, of subnormal look and low intellectual level is translocated. The children, born with a weight and size much below the average, show a very special morphotype: a hook-nose, an abnormal conformation of the back edge of the nostrils (a protrusion in the shape of a horn overhanging the filtrum), hypertelorism, microcephaly. Great asynchronism in the maturation of the bones and a somatoschisis of the body of the cervical vertebrae are noted. Deletion of the short arm chromosome 4 is juxtacentromeric. The study of blood and tissue groups corroborates monozygosity. Dermatoglyphs are little abnormal and identical in the two children. The mother's family is phenotypically normal. At 19 months of age, measuring is still below 4, psychomotor progress is extremely weak, and convulsions are frequent.

Tumor Microenvironment-Triggered In-Situ Cancer Vaccines with Dual Immunogenic Cell Death Inductions for Elevated Antitumor and Antimetastatic Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jun Lin ◽  
Binbin Ding ◽  
Pan Zheng ◽  
Dong Li ◽  
Meifang Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Microenvironment ◽  
Immune Responses ◽  
Cancer Immunotherapy ◽  
Cancer Vaccines ◽  
High Specificity ◽  
The Body ◽  
Immunogenic Cell Death ◽  
Specific Antigens

Cancer vaccine is to make tumor-specific antigens into vaccines, which then are injected back into the body to activate immune responses for cancer immunotherapy. Despite the high specificity and therapeutic...

Expression of a novel FGF in the Xenopus embryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification

Development ◽  
1992 ◽  
Vol 114 (3) ◽  
pp. 711-720 ◽  
Author(s):  
H.V. Isaacs ◽  
D. Tannahill ◽  
J.M. Slack
Keyword(s):  
Specific Activity ◽  
Biological Properties ◽  
The Body ◽  
Mesoderm Induction ◽  
Gastrula Stage ◽  
Blastula Stage ◽  
Mesoderm Formation ◽  
Low Levels

We have cloned and sequenced a new member of the fibroblast growth factor family from Xenopus laevis embryo cDNA. It is most closely related to both mammalian kFGF (FGF-4) and FGF-6 but as it is not clear whether it is a true homologue of either of these genes we provisionally refer to it as XeFGF (Xenopus embryonic FGF). Two sequences were obtained, differing by 11% in derived amino acid sequence, which probably represent pseudotetraploid variants. Both the sequence and the behaviour of in vitro translated protein indicates that, unlike bFGF (FGF-2), XeFGF is a secreted molecule. Recombinant XeFGF protein has mesoderm-inducing activity with a specific activity similar to bFGF. XeFGF mRNA is expressed maternally and zygotically with a peak during the gastrula stage. Both probe protection and in situ hybridization showed that the zygotic expression is concentrated in the posterior of the body axis and later in the tailbud. Later domains of expression were found near the midbrain/hindbrain boundary and at low levels in the myotomes. Because of its biological properties and expression pattern, XeFGF is a good candidate for an inducing factor with possible roles both in mesoderm induction at the blastula stage and in the formation of the anteroposterior axis at the gastrula stage.

scholarly journals Injectable and Gellable Chitosan Formulations Filled with Cellulose Nanofibers for Intervertebral Disc Tissue Engineering

Polymers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1202 ◽  
Author(s):  
Ingo Doench ◽  
Maria Torres-Ramos ◽  
Alexandra Montembault ◽  
Paula Nunes de Oliveira ◽  
Celia Halimi ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Rheological Behavior ◽  
Biomedical Application ◽  
Flow Behavior ◽  
Cellulose Nanofibers ◽  
Nanofibrillated Cellulose ◽  
The Body ◽  
Mechanical Reinforcement ◽  
Invasive Approach

The development of non-cellularized injectable suspensions of viscous chitosan (CHI) solutions (1.7–3.3% (w/w)), filled with cellulose nanofibers (CNF) (0.02–0.6% (w/w)) of the type nanofibrillated cellulose, was proposed for viscosupplementation of the intervertebral disc nucleus pulposus tissue. The achievement of CNF/CHI formulations which can gel in situ at the disc injection site constitutes a minimally-invasive approach to restore damaged/degenerated discs. We studied physico-chemical aspects of the sol and gel states of the CNF/CHI formulations, including the rheological behavior in relation to injectability (sol state) and fiber mechanical reinforcement (gel state). CNF-CHI interactions could be evidenced by a double flow behavior due to the relaxation of the CHI polymer chains and those interacting with the CNFs. At high shear rates resembling the injection conditions with needles commonly used in surgical treatments, both the reference CHI viscous solutions and those filled with CNFs exhibited similar rheological behavior. The neutralization of the flowing and weakly acidic CNF/CHI suspensions yielded composite hydrogels in which the nanofibers reinforced the CHI matrix. We performed evaluations in relation to the biomedical application, such as the effect of the intradiscal injection of the CNF/CHI formulation in pig and rabbit spine models on disc biomechanics. We showed that the injectable formulations became hydrogels in situ after intradiscal gelation, due to CHI neutralization occurring in contact with the body fluids. No leakage of the injectate through the injection canal was observed and the gelled formulation restored the disc height and loss of mechanical properties, which is commonly related to disc degeneration.

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