Effects of Breast Cancer and Mastectomy on Fibrinolytic Activity in African Women / Effets du cancer du sein et de la mammectomie sur l'activité fibrinolytique chez les femmes africaines

2006 ◽  
Vol 10 (3) ◽  
pp. 114
Author(s):  
Elusoji S. O. Famodu ◽  
A. A. Fakoya ◽  
T.a. Barhua F.j ◽  
C. O. Osime ◽  
E. Egwaikhide ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Du Sein ◽  
Fibrinolytic Activity ◽  
African Women

Abnormal fibrinolytic activity in African women taking oral contraceptives

1993 ◽  
Vol 4 (4) ◽  
pp. 641-644 ◽  
Author(s):  
A. A. Famodu ◽  
E. U. Elom ◽  
A. E. Ehigiegba ◽  
T. A. Fakoya
Keyword(s):  
Oral Contraceptives ◽  
Fibrinolytic Activity ◽  
African Women

scholarly journals Breast cancer screening uptake among women from different ethnic groups in London: a population-based cohort study

BMJ Open ◽  
2014 ◽  
Vol 4 (10) ◽  
pp. e005586 ◽  
Author(s):  
Ruth H Jack ◽  
Henrik Møller ◽  
Tony Robson ◽  
Elizabeth A Davies
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Ethnic Groups ◽  
Breast Cancer Screening ◽  
Population Based ◽  
African Women ◽  
Black African ◽  
Screening Uptake ◽  
Black And White ◽  
Black Caribbean

ObjectiveTo use newly available self-assigned ethnicity information to investigate variation in breast cancer screening uptake for women from the 16 specific ethnic groups within the broad Asian, Black and White groups that previous studies report.SettingNational cancer screening programme services within London.Participants655 516 female residents aged 50–69, invited for screening between March 2006 and December 2009. Ethnicity information was available for 475 478 (72.5%). White British women were the largest group (306 689, 46.8%), followed by Indian (34 687, 5.3%), White Other (30 053, 4.6%), Black Caribbean (25 607, 3.9%), White Irish (17 271, 2.6%), Black African (17 071, 2.6%) and Asian Other (10 579, 1.6%).Outcome measuresUptake for women in different ethnic groups aged 50–52 for a first call invitation to the programme, and for women aged 50–69 for a routine recall invitation after a previous mammography. Uptake is reported (1) for London overall, adjusted using logistic regression, for age at invitation, socioeconomic deprivation and geographical screening area, and (2) for individual areas, adjusted for age and deprivation.ResultsWhite British women attended their first call (67%) and routine recall (78%) invitations most often. Indian women were more likely to attend their first (61%) or routine recall (74%) than Bangladeshi women (43% and 61%, respectively), and Black Caribbean women were more likely than Black African women to attend first call (63% vs 49%, respectively) and routine recall (74% vs 64%, respectively). There was less variation between ethnic groups in some screening areas.ConclusionsBreast cancer screening uptake in London varies by specific ethnic group for first and subsequent invitations, with White British women being more likely to attend. The variation in the uptake for women from the same ethnic groups in different geographical areas suggests that collaboration about the successful engagement of services with different communities could improve uptake for all women.

Perceptions of control, physical exercise, and psychological adjustment to breast cancer in South African women

1997 ◽  
Vol 19 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Barbara A. Bremer ◽  
Cathleen T. Moore ◽  
Barbara M. Bourbon ◽  
Dawn R. Hess ◽  
Kristin L. Bremer
Keyword(s):  
Breast Cancer ◽  
Physical Exercise ◽  
South African ◽  
Psychological Adjustment ◽  
African Women ◽  
South African Women

scholarly journals Health system experiences of breast cancer survivors in urban South Africa

2020 ◽  
Vol 16 ◽  
pp. 174550652094941
Author(s):  
Madeleine Lambert ◽  
Emily Mendenhall ◽  
Andrew Wooyoung Kim ◽  
Herbert Cubasch ◽  
Maureen Joffe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
South Africa ◽  
Black Women ◽  
Health System ◽  
South African ◽  
Breast Cancer Survivors ◽  
Radiation Treatment ◽  
African Women ◽  
Total Mastectomy ◽  
South African Women

Background: Breast cancer is the most common cancer globally and among South African women. Women from socioeconomically disadvantaged South African communities more often present later and receive total mastectomy compared to those from more affluent communities who have more breast conserving surgery (which is less invasive but requires mandatory radiation treatment post-operatively). Standard chemotherapy and total mastectomy treatments are known to cause traumatizing side effects and emotional suffering among South African women; moreover, many women face limited communication with physicians and psychological support. Objective: This article investigates the experiences of women seeking breast cancer treatment at the largest public hospital in South Africa. Methods We interviewed 50 Black women enrolled in the South African Breast Cancer Study to learn more about their health system experiences with detection, diagnosis, treatment, and follow-up care for breast cancer. Each interview was between 2–3 hours, addressing perceptions, experiences, and concerns associated with breast cancer and comorbidities such as HIV and hypertension. Results: We found most women feared diagnosis, in part, because of the experience of chemotherapy and physical mutilation related to mastectomy. The importance of social support from family, religion, and clinical staff was fundamental for women coping with their condition and adhering to treatment and medication. Conclusions: These findings exemplify how interventions might promote early detection of breast cancer and better adherence to treatment. Addressing community perceptions of breast cancer, patient needs and desires for treatment, structural barriers to intensive therapies, and the burden of invasive treatments are imperative next steps for delivering better breast cancer care in Soweto and other resource-constrained settings.

scholarly journals Triple Negative Breast Cancer: A review of common therapeutic Targets and Current Treatment options.

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Daud Akhtar ◽  
Ahsen Chaudhry
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Side Effects ◽  
Triple Negative Breast Cancer ◽  
Cancer Du Sein ◽  
Triple Negative ◽  
Treatment Options ◽  
Cell Signalling ◽  
Effets Secondaires ◽  
Breast Cancer Chemotherapy

Triple negative breast cancer (TNBC) is a subtype of breast cancer which lacks ER, PR, and HER2 expression. It is characterized by poor prognosis and resistance to standard treatment forms for breast cancer. Chemotherapy is still currently the core neo-adjuvant treatment option for patients with TNBC, although it has mixed levels of efficacy on overall survival and many serious side effects. Platinum- based therapies have been used to treat TNBC in conjunction with chemotherapy, but they are not a widely effective treatment due to the heterogeneity of TNBC. For this reason, other novel approaches, particularly those which target molecular components involved in TNBC pathogenesis, are being investigated. Angiogenesis inhibitors, which include monoclonal antibodies or small molecules that inhibit VEGF, have been shown to improve progression-free survival, but have not demonstrated an impact on overall survival. PARP enzyme inhibitors, when combined with chemotherapy and carboplatin for the treatment of TNBC, have demonstrated a significant reduction in risk progression and mortality. However, the majority of PARP inhibitors are still in trials and their effectiveness in clini- cal settings has yet to be determined. Additional proposed targets for directed therapy against TNBC include cell signalling pathways involving EGFR or PI3K. Overall, issues such as treatment resistance and side effects are important challenges that must be overcome in order to enable improvements in patient prognosis and clinical impact. RÉSUMÉ Le cancer du sein triple négatif (CSTN) est un sous-type de cancer du sein auquel il manque les récepteurs d’œstrogènes (ER), les récepteurs de progestérone (PR) et l’expression de HER2. Il est caractérisé par un pronostic défavorable et une résistance aux traite- ments standards du cancer du sein. À l’heure actuelle, la chimiothérapie est encore l’option principale de traitement néoadjuvant pour les patients ayant le CSTN, bien qu’elle ait des niveaux variés d’efficacité sur la survie globale, ainsi que de nombreux effets secondaires sérieux. Les thérapies à base de platine ont été utilisées pour traiter le CSTN en conjonction avec la chimiothérapie, mais elles ne sont pas très efficaces étant donné l’hétérogénéité du CSTN. En raison de cela, d’autres approches novatrices, particulièrement celles qui ciblent les composantes moléculaires impliquées dans la pathogenèse du CSTN, font actuellement l’objet d’enquêtes. Les inhibiteurs de l’angiogenèse, dont les anticorps monoclonaux ou les petites molécules inhibant le VEGF, ont démontré la capacité d’améliorer la survie sans progression de la maladie, mais n’ont pas démontré d’impact sur la survie globale. Les inhibiteurs d’enzymes PARP, lorsque combinés avec la chimiothérapie et le carboplatine pour le traitement du CSTN, ont démontré une réduction significative du risque de progression et de la mortalité. Toutefois, la majorité des inhibiteurs PARP subissent encore des essais et leur efficacité clinique reste à être déterminée. D’autres cibles suggérées pour la thérapie dirigée contre le CSTN incluent les voies de signalisation impliquant le EGFR ou le PI3K. Dans l’ensemble, des problèmes tels la résistance au traitement et les effets secondaires sont des défis importants qui doivent être surmontés afin de permettre des améliorations au niveau du pronostic du patient et de l’impact clinique. 

scholarly journals Clinico-pathological characteristics among South African women with breast cancer receiving anti-retroviral therapy for HIV

The Breast ◽  
2019 ◽  
Vol 43 ◽  
pp. 123-129
Author(s):  
Boitumelo Phakathi ◽  
Herbert Cubasch ◽  
Sarah Nietz ◽  
Caroline Dickens ◽  
Therese Dix-Peek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
South African ◽  
African Women ◽  
Pathological Characteristics ◽  
South African Women

scholarly journals Epidemiology of Breast Cancer in Europe and Africa

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Ganiy Opeyemi Abdulrahman ◽  
Ganiyu Adebisi Rahman
Keyword(s):  
Breast Cancer ◽  
Genetic Factors ◽  
Ductal Carcinoma ◽  
Molecular Level ◽  
Early Stage ◽  
Survival Rates ◽  
African Women ◽  
Black African ◽  
The World ◽  
European Women

Breast cancer continues to remain the most lethal malignancy in women across the world. This study reviews some of the epidemiological similarities and differences in breast cancer between white European women and black African women with the aim of optimising care for women with breast malignancy across the world. The incidence of breast cancer is lower among African women than their European counterparts. Majority of women in Europe are postmenopausal when they present with breast cancer; however, the peak incidence among African women is in the premenopausal period. Ductal carcinoma is the commonest type of breast cancer among women in Africa and Europe. However, medullary and mucinous carcinomas are more common in Africa than in Europe. While European women usually present at an early stage especially with the advent of screening, African women generally present late for treatment resulting in lower survival rates. There should be more research at the molecular level among African women to identify genetic factors that may contribute to the risk of developing breast cancer. There should also be improvement in the health care system in Africa in order to optimise care for women with breast cancer.

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