John Horsley

1932 ◽  
Vol 22 (2) ◽  
pp. 161-164
Author(s):  
George Macdonald
Keyword(s):  
Great Book ◽  
Early Age ◽  
Present Purpose ◽  
First Time

On January 12th, 1732, John Horsley, Presbyterian divine and schoolmaster, died suddenly at Morpeth at the early age of 46. The following March or April witnessed the publication of his great book, in which real scholarship was for the first time brought to bear upon the interpretation of Romano-British antiquities. The occurrence of this double bicentenary seems to provide an appropriate opportunity for reminding readers of the Journal of the magnitude of the achievement represented by the Britannia Romana. A fully documented account of the author's career, together with an estimate of the value of his work, will appear in the forthcoming volume of Archaeologia Aeliana. For the present purpose, therefore, a brief summary will suffice.

Pregnancy and the Risk of Rheumatoid Arthritis in a Highly Predisposed North American Native Population

2012 ◽  
Vol 39 (12) ◽  
pp. 2253-2260 ◽  
Author(s):  
CHRISTINE A. PESCHKEN ◽  
DAVID B. ROBINSON ◽  
CAROL A. HITCHON ◽  
IRENE SMOLIK ◽  
DONNA HART ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
North American ◽  
Shared Epitope ◽  
Reproductive History ◽  
Early Age ◽  
Age At First Birth ◽  
Native Population ◽  
First Birth ◽  
Pregnancy Smoking ◽  
First Time

Objective.To examine reproductive history and rheumatoid arthritis (RA) risk in a highly predisposed population of North American Natives (NAN) with unique fertility characteristics.Methods.The effect of pregnancy on the risk of RA was examined by comparing women enrolled in 2 studies: a study of RA in NAN patients and their unaffected relatives; and NAN patients with RA and unrelated healthy NAN controls enrolled in a study of autoimmunity. All participants completed questionnaires detailing their reproductive history.Results.Patients with RA (n = 168) and controls (n = 400) were similar overall in age, education, shared epitope frequency, number of pregnancies, age at first pregnancy, smoking, and breastfeeding history. In multivariate analysis, for women who had ≥ 6 births the OR for developing RA was 0.43 (95% CI 0.21–0.87) compared with women who had 1–2 births (p = 0.046); for women who gave birth for the first time after age 20 the OR for developing RA was 0.33 (95% CI 0.16–0.66) compared with women whose first birth occurred at age ≤ 17 (p = 0.001). The highest risk of developing RA was in the first postpartum year (OR 3.8; 95% CI 1.45–9.93) compared with subsequent years (p = 0.004).Conclusion.In this unique population, greater parity significantly reduced the odds of RA; an early age at first birth increased the odds, and the postpartum period was confirmed as high risk for RA onset. The protective effect of repeated exposure to the ameliorating hormonal and immunological changes of pregnancy may counterbalance the effect of early exposure to the postpartum reversal of these changes.

scholarly journals Characterization of Titanium Nanotube Reinforced Cementitious Composites: Mechanical Properties, Microstructure, and Hydration

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1617 ◽  
Author(s):  
Hyeonseok Jee ◽  
Jaeyeon Park ◽  
Erfan Zalnezhad ◽  
Keunhong Jeong ◽  
Seung Min Woo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Cement Paste ◽  
Cementitious Materials ◽  
Cement Clinker ◽  
Early Age ◽  
Potential Candidate ◽  
Hydration Kinetics ◽  
Cement Pastes ◽  
Viable Solution ◽  
First Time

In recent years, nano-reinforcing technologies for cementitious materials have attracted considerable interest as a viable solution for compensating the poor cracking resistance of these materials. In this study, for the first time, titanium nanotubes (TNTs) were incorporated in cement pastes and their effect on the mechanical properties, microstructure, and early-age hydration kinetics was investigated. Experimental results showed that both compressive (~12%) and flexural strength (~23%) were enhanced with the addition of 0.5 wt.% of TNTs relative to plain cement paste at 28 days of curing. Moreover, it was found that, while TNTs accelerated the hydration kinetics of the pure cement clinker phase (C3S) in the early age of the reaction (within 24 h), there was no significant effect from adding TNTs on the hydration of ordinary Portland cement. TNTs appeared to compress the microstructure by filling the cement paste pore of sizes ranging from 10 to 100 nm. Furthermore, it could be clearly observed that the TNTs bridged the microcracks of cement paste. These results suggested that TNTs could be a great potential candidate since nano-reinforcing agents complement the shortcomings of cementitious materials.

The Date of the Athena Rospigliosi Type

1923 ◽  
Vol 43 (2) ◽  
pp. 176-182
Author(s):  
Oscar Waldhauer
Keyword(s):  
Type I ◽  
Present Purpose ◽  
Sea Monster ◽  
Formed Part ◽  
First Time

The great number of replicas of the youthful Athena known as the Rospigliosi type proves that the original was a famous statue. The bad state of preservation as well as variations in the different copies have made it difficult to date the original; the lack of good reproductions has also caused misunderstandings and has led astray the scholars who have dealt with the type. I think it necessary, therefore, to publish here a Hermitage fragment of very good workmanship, which is untouched and unrestored by any modern master. I shall not here undertake to explain the strange attributes—stars on the aegis, sea-monster in the Rospigliosi statue; the present purpose is merely to fix the date of the original.The fragment reproduced here for the first time in fairly good photographs (Plates VII., VIII.) was found in 1823 in the so-called Vigna del Collegio Inglese on the Palatine at Rome, and formed part of the Museo Campana until 1861. The Emperor Alexander II bought a part of this collection for the Hermitage; among these marbles the fragment of the Athena statue found its way to the then newly-arranged Museum of Ancient Sculpture. Being only a fragment it was exhibited in a rather dark corner and could not be sufficiently well studied. A rough drawing in Gerhard's Antike Denkmäler and a very small illustration in Kieseritzky's Catalogue of 1901 were the only accessible publications.

Whole exome sequencing of germline DNA of individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced lung adenocarcinoma (LUAD) according to KRAS status.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 1540-1540
Author(s):  
Jose Luis Perez-Gracia ◽  
Guillermo Pita ◽  
Victor Segura ◽  
Maria Jose Pajares ◽  
Juan Pablo Fusco ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Low Risk ◽  
Exome Capture ◽  
Early Age ◽  
Mutation Status ◽  
Whole Exome ◽  
Kras Status ◽  
Extreme Phenotypes ◽  
First Time ◽  
Susceptibility And Resistance

1540 Background: Individual susceptibility to carcinogens may depend on the genetic background. We characterized the constitutional exome of individuals presenting extreme phenotypes of high sensitivity and resistance to develop tobacco induced LUAD, correlating the results to KRAS status. Methods: From an identification cohort (n=3,631) we selected 100 caucasian heavy smokers that either developed LUAD at early age (cancer cohort, n=50) or did not develop LUAD or other tumors at advanced age (cancer free cohort, n=50). We sequenced their germline DNA with the Agilent Human Exome Capture v5 (21,522 genes, 357,999 exons). Using logistic regression we selected the most significant variants between both cohorts and correlated them with KRAS mutation status of LUAD patients. Results: mean ages for the cancer and cancer free cohorts were 50 (range 34-55) and 78 years (72-90). Mean tobacco consumptions were 44 (range 6-72) and 55 pack-years (20-124). Median coverage was 96% at >10X; median depth was 97X. Table shows the most significant variants. rs7240666 ( ALPK2) achieved top significance (p=8.14x10-5, OR 0.18). rs78898229 ( ANKRD36C) and rs74866537 ( PTPN4) were predominantly represented in patients with KRAS+ tumors, OR: 16 (3.3-78) and 11.9 (3.3-43); and rs12426243 (CCDC41) in KRAS- tumors (OR: 13 (3-53). Conclusions: Our study characterizes for the first time the genotype of individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced LUAD according to KRAS status. Our results warrants further study to assess their value to screen these clinically relevant phenotypes; and to identify mechanisms of high susceptibility and resistance to carcinogens. [Table: see text]

Pepys, Fuller and an Archbishop

1945 ◽  
Vol 38 (1) ◽  
pp. 71-73
Author(s):  
B. J. Whiting
Keyword(s):  
Coming Out ◽  
Great Book ◽  
Busy Time ◽  
History Of ◽  
First Time

Among young Samuel Pepys's many acquaintances was Thomas Fuller, antiquary, historian, preacher, biographer and wit. Fuller died on August 16, 1661, but he had previously appeared more than once in the Diary. On May 17, 1660, Pepys had a rapturously busy time at court: “After that, going to see the Queen of Bohemia, I met with Dr. Fuller, whom I sent to a tavern with Mr. Edw. Pickering, while I and the rest went to see the Queen. …” Early the next year (January 5, 1661), “Several people came to me about business, among others the great Tom Fuller, who came to desire a kindness for a friend of his … which I promised to do.” Later in the month (January 22) “I met with Dr. Thomas Fuller and took him to the Dog, where he tells me of his last and great book that is coming out: that is, his History of all the Families in England; and could tell me more of my own, than I knew myself.” In the same conversation Fuller talked with great complacence and detail about his own feats of memory. Twice Pepys heard Fuller preach: the first time (February 3, 1661), he commended a point made by the speaker, but on May 12, 1661, he was forced to admit, “methought it was a poor dry sermon.” He heard of Fuller's death, “of a sort of fever” then prevalent, on the day it occurred, and called him “the famous Tom Fuller.”

scholarly journals Educating young people to patriotism in the epic "Forty Girls"

2020 ◽  
Vol 3 (11) ◽  
pp. 137-139
Author(s):  
А. T. Saparov
Keyword(s):  
Young People ◽  
Native Language ◽  
Early Age ◽  
First Time

People are born and raised from an early age and watch the nature of the place where they work. He learns language and customs. He also learns the words mother, father, country, homeland in his native language for the first time and communicates with each other. They are committed to self-sacrifice in their homeland. He amasses wealth for his country and people, creates wealth, protect his homeland from external enemies.

scholarly journals Assessment of the potential damaging effect of radiofrequency exposure in children in prospective follow-up (case report series)

2020 ◽  
Vol 35 (3) ◽  
pp. 116-124
Author(s):  
O. Yu. Dzhaffarova ◽  
L. I. Svintsova ◽  
I. V. Plotnikova ◽  
S. N. Krivolapov ◽  
E. O. Kartofeleva
Keyword(s):  
Electrophysiological Study ◽  
Electrical Signal ◽  
Coagulation Necrosis ◽  
Early Age ◽  
Follow Up Study ◽  
Rf Exposure ◽  
First Time ◽  
New Onset

Aim: To evaluate the electrical activity of the myocardium and the radiofrequency (RF) application zone resulting from radiofrequency ablation (RFA) performed at an early age.Material and Methods. A prospective follow-up study included three patients who underwent intracardiac electrophysiological study (EPS) and effective RFA of the tachycardia for the first time at an early age. A reintervention was required in one case 12 years after the procedure and in two cases six years after it due to recurrent and new-onset arrhythmias. During the reintervention, electroanatomical mapping was performed to assess the potential damaging effect of radiofrequency exposure in the area of the first ablation.Results. The intracardiac EPS and amplitude bipolar CARTO-reconstruction of primary ablation area were performed during repeated RFA procedure. The study showed that neither zones with a decrease in the amplitude of electrical signal from the myocardium nor silent electrical zones were present ruling out the cicatricial-sclerotic changes in the myocardium in children in the long-term period after RF exposure.Conclusion. The study showed that no increase in the coagulation necrosis zone in the area of primary ablation occurred during the growth of child when the sparing energy and temperature parameters of RFA and the limited number of RF applications were used. Further research in this area is required.

scholarly journals IS OUR CHILD TOO YOUNG TO LEARN ABOUT GENDER EQUALITY? AN INTERPRETATION OF GENDER EDUCATION IN ACEH FAMILIES

2020 ◽  
Vol 6 (2) ◽  
pp. 33
Author(s):  
Muhammad Zawil Kiram
Keyword(s):  
Gender Equality ◽  
Violence Against Women ◽  
Gender Stereotypes ◽  
Gender Issues ◽  
Early Age ◽  
Gender Education ◽  
The Family ◽  
Gender Based ◽  
And Gender ◽  
First Time

This study aims to reveal gender-based discrimination, forms of gender education, and the importance of gender education in Acehnese families. This study was conducted by using the method of descriptive qualitative with data collection techniques through observation and interview. The result showed that in Acehnese families, the forms of gender-based discrimination that often faced by women are inequality in housework distribution and childcare. In Aceh, most men still play fewer roles in taking care of children because domestic jobs are seen to be women’s’ responsibilities. Another form of gender-based discrimination in Aceh is domestic violence against women. The result also demonstrated that in Acehnese families there is no gender education because many people do not understand the term of gender equality and gender issues are considered as western culture and still taboo to discuss. Gender education in the family is important because children acquire gender stereotypes at an early age, and they learn about gender equality from their family for the first time. Teaching gender equality to children is never too early, and they never too young to learn about it, they would come out and bring the gender equality in the family and society in general as they will be the pioneer or gender equality when they reach adulthood.

scholarly journals Awareness and Practices of Complementary and Alternative Medicine among Paediatric Patients Visiting Two Tertiary Care Hospitals in Mangaluru: An Interview Based Study

2020 ◽  
Vol 13 (4) ◽  
pp. 1737-1743
Author(s):  
Meghana Tiwary ◽  
Amrita Parida ◽  
Manju V
Keyword(s):  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Tertiary Care ◽  
Concomitant Administration ◽  
Structured Interview ◽  
Early Age ◽  
Paediatric Outpatient ◽  
Tertiary Care Hospitals ◽  
First Time ◽  
Complementary And Alternative

This study aims to find out the details of complementary and alternative medicine (CAM) use in children, including factors favouring their use and concomitant usage of allopathic drugs along with CAM. The study also analyses the communication between allopathic practitioners and patients regarding utilization of CAM. It was an interview based study based on a semi-structured interview. The study sample included parents of children waiting in the paediatric outpatient department. A total of 200 parents were interviewed. Though most of the parents were aware about CAM, around 10% parents were ignorant. Ayurveda was the most commonly used CAM followed by homeopathy. Fifty-four children had taken CAM for the first time at an age of less than 6 months. The most common condition for which children were taking CAM was related to the diseases of respiratory system. The primary reason for preferring CAM over allopathy is that they believe it is natural and has no adverse effects. Only 23% of the parents voluntarily informed the doctors that the child was taking CAM concurrently and half of the parents stated that the treating physician did not enquire regarding CAM therapy. As evident from the study, use of CAM in children starts at a very early age hence the safety and efficacy of these therapies should be well established before children are exposed to them. Hazards of concomitant administration of CAM along with allopathic medicines should also be carefully evaluated by all the treating physicians.

scholarly journals A shift towards early-age desexing of cats under veterinary care in Australia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Loic Mazeau ◽  
Claire Wylie ◽  
Lara Boland ◽  
Julia A. Beatty
Keyword(s):  
Reproductive Success ◽  
Animal Welfare ◽  
Sexual Maturity ◽  
Early Age ◽  
Patient Records ◽  
Electronic Patient Records ◽  
Domestic Cats ◽  
Front Line ◽  
Age At Surgery ◽  
First Time

AbstractThe global problem of unowned domestic cats, driven by their phenomenal reproductive success, carries significant economic, animal welfare and biodiversity costs. Desexing owned cats prior to puberty prevents unwanted litters that contribute to unowned cat populations. The prevalence and predictors of desexing, and the age at which surgery was carried out were investigated using anonymized electronic patient records in the VetCompass Australia database of cats presented to veterinary practices. Of 52,941 cats born between 2010 and 2017, 83.6% were desexed. Among 7463 desexed females, 21.5% had been desexed by 4 months of age, 59.8% by 6 months and 85.4% by 1 year. Sex, breed, location and socioeconomic indices significantly influenced desexing status and age at surgery. Cats born between 2010 and 2017 had greater odds of being desexed than cats born between 1995and 2009 at each age cut-off (≤ 4 months [OR 1.76, CI95 1.58–1.97], ≤ 6 months [OR 1.50, CI95 1.38–1.62] and ≤ 1 year [OR 2.33, CI95 2.11–2.57] p < 0.001). Most cats presented to veterinarians in Australia are desexed. Compared with cats born before 2010, cats born later are significantly younger at desexing but, even so, many cats would have reached sexual maturity before surgery. These findings will inform the design of front-line strategies promoting prepubertal desexing and they demonstrate, for the first time, a shift towards desexing younger cats.

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