U.S. Survey Confirms Pill, Liver Tumor Link

1977 ◽  
Vol 3 (3) ◽  
pp. 15
Keyword(s):  
Author(s):  
K Beller ◽  
H Weiler ◽  
B Riecken ◽  
K Caca

2000 ◽  
Vol 20 (02) ◽  
pp. 227-232 ◽  
Author(s):  
Arief Suriawinata ◽  
Katya Ivanov ◽  
Menahem Ben Haim ◽  
Myron E. Schwartz

2000 ◽  
Vol 18 ◽  
pp. 121-125
Author(s):  
Takashi Shibata ◽  
Takahiro Niinobu ◽  
Masashi Kitada ◽  
Takashi Shimano ◽  
Motohisa Takami ◽  
...  

2010 ◽  
Vol 38 (1) ◽  
pp. 31-52 ◽  
Author(s):  
Christian Schumann ◽  
Christian Rieder ◽  
Jennifer Bieberstein ◽  
Andreas Weihusen ◽  
Stephan Zidowitz ◽  
...  

1978 ◽  
Vol 40 (5) ◽  
pp. 817-821 ◽  
Author(s):  
Kazuo SAITO ◽  
Seiji ARASE ◽  
Fumio SHIGEMI ◽  
Katsuyuki TAKEDA

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 76
Author(s):  
Maria Wedin ◽  
Sagar Mehta ◽  
Jenny Angerås-Kraftling ◽  
Göran Wallin ◽  
Kosmas Daskalakis

Our aim was to investigate the clinical utility of serum 5HIAA for disease surveillance and diagnostic purposes in a cohort of patients with well-differentiated neuroendocrine neoplasms (WD-NENs). Forty-eight patients with WD-NENs and concurrent serum and urinary 5HIAA testing, as well as CT/MRI imaging, were included. Analysis of matching-pairs did not reveal any association between RECIST 1.1 responses and changes in serum 5HIAA levels (p = 0.673). In addition, no correlation was evident between RECIST 1.1 responses and >10%, >25% or >50% changes in serum 5HIAA levels (Fisher’s exact test p = 0.380, p > 0.999, and p > 0.999, respectively). The presence of liver metastases and extensive liver tumor involvement were associated with higher serum 5HIAA levels (p = 0.045 and p = 0.041, respectively). We also confirmed a strong linear correlation between the measurements of serum and urine 5HIAA (n = 24, r = 0.791, p < 0.0001). The concordance rate of serum and urinary 5HIAA positivity at standardized laboratory cut-offs was 75%. In patients with normal renal function tests, the concordance between the two methods was as high as 89%, and a sensitivity and specificity of 80% and 88.9%, respectively, was evident (Cohen’s kappa coefficient = 0.685). In conclusion, serum 5HIAA performs well compared to urinary testing for diagnostic purposes, mainly in advanced disease stages, and corresponds well to liver tumor burden. However, it is not adequate to predict tumor progression.


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