Natural Selection on Thermogenic Capacity of High-Altitude Deer Mice

Evolution ◽  
1999 ◽  
Vol 53 (4) ◽  
pp. 1280 ◽  
Author(s):  
Jack P. Hayes ◽  
Candace S. O'Connor
Keyword(s):  
Natural Selection ◽  
High Altitude ◽  
Deer Mice ◽  
Thermogenic Capacity

scholarly journals NATURAL SELECTION ON THERMOGENIC CAPACITY OF HIGH-ALTITUDE DEER MICE

Evolution ◽  
1999 ◽  
Vol 53 (4) ◽  
pp. 1280-1287 ◽  
Author(s):  
Jack P. Hayes ◽  
Candace S. O'Connor
Keyword(s):  
Natural Selection ◽  
High Altitude ◽  
Deer Mice ◽  
Thermogenic Capacity

scholarly journals Individual variation in thermogenic capacity affects above-ground activity of high-altitude Deer Mice

2006 ◽  
Vol 20 (1) ◽  
pp. 97-104 ◽  
Author(s):  
M. W. SEARS ◽  
J. P. HAYES ◽  
C. S. O'CONNOR ◽  
K. GELUSO ◽  
J. S. SEDINGER
Keyword(s):  
High Altitude ◽  
Individual Variation ◽  
Deer Mice ◽  
Thermogenic Capacity

scholarly journals Regulatory changes contribute to the adaptive enhancement of thermogenic capacity in high-altitude deer mice

2012 ◽  
Vol 109 (22) ◽  
pp. 8635-8640 ◽  
Author(s):  
Z. A. Cheviron ◽  
G. C. Bachman ◽  
A. D. Connaty ◽  
G. B. McClelland ◽  
J. F. Storz
Keyword(s):  
High Altitude ◽  
Deer Mice ◽  
Regulatory Changes ◽  
Adaptive Enhancement ◽  
Thermogenic Capacity

scholarly journals Coordinated changes across the O 2 transport pathway underlie adaptive increases in thermogenic capacity in high-altitude deer mice

2020 ◽  
Vol 287 (1927) ◽  
pp. 20192750 ◽  
Author(s):  
Kevin B. Tate ◽  
Oliver H. Wearing ◽  
Catherine M. Ivy ◽  
Zachary A. Cheviron ◽  
Jay F. Storz ◽  
...  
Keyword(s):  
High Altitude ◽  
Complex Traits ◽  
Deer Mice ◽  
Transport Pathway ◽  
Physiological Mechanisms ◽  
Critical Determinant ◽  
In Captivity ◽  
Low Altitude ◽  
Hypoxia Acclimation ◽  
Thermogenic Capacity

Animals native to the hypoxic and cold environment at high altitude provide an excellent opportunity to elucidate the integrative mechanisms underlying the adaptive evolution and plasticity of complex traits. The capacity for aerobic thermogenesis can be a critical determinant of survival for small mammals at high altitude, but the physiological mechanisms underlying the evolution of this performance trait remain unresolved. We examined this issue by comparing high-altitude deer mice ( Peromyscus maniculatus ) with low-altitude deer mice and white-footed mice ( P. leucopus ). Mice were bred in captivity and adults were acclimated to each of four treatments: warm (25°C) normoxia, warm hypoxia (12 kPa O 2 ), cold (5°C) normoxia or cold hypoxia. Acclimation to hypoxia and/or cold increased thermogenic capacity in deer mice, but hypoxia acclimation led to much greater increases in thermogenic capacity in highlanders than in lowlanders. The high thermogenic capacity of highlanders was associated with increases in pulmonary O 2 extraction, arterial O 2 saturation, cardiac output and arterial–venous O 2 difference. Mechanisms underlying the evolution of enhanced thermogenic capacity in highlanders were partially distinct from those underlying the ancestral acclimation responses of lowlanders. Environmental adaptation has thus enhanced phenotypic plasticity and expanded the physiological toolkit for coping with the challenges at high altitude.

scholarly journals Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice

2017 ◽  
Vol 220 (20) ◽  
pp. 3616-3620 ◽  
Author(s):  
Kevin B. Tate ◽  
Catherine M. Ivy ◽  
Jonathan P. Velotta ◽  
Jay F. Storz ◽  
Grant B. McClelland ◽  
...  
Keyword(s):  
High Altitude ◽  
Deer Mice ◽  
Thermogenic Capacity

scholarly journals FUNCTIONAL GENOMICS OF ADAPTATION TO HYPOXIC COLD-STRESS IN HIGH-ALTITUDE DEER MICE: TRANSCRIPTOMIC PLASTICITY AND THERMOGENIC PERFORMANCE

Evolution ◽  
2013 ◽  
Vol 68 (1) ◽  
pp. 48-62 ◽  
Author(s):  
Zachary A. Cheviron ◽  
Alex D. Connaty ◽  
Grant B. McClelland ◽  
Jay F. Storz
Keyword(s):  
Cold Stress ◽  
Functional Genomics ◽  
High Altitude ◽  
Deer Mice
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