Statistical Methods in Cancer Research, Vol. II: The Design and Analysis of Cohort Studies.

Biometrics ◽  
1990 ◽  
Vol 46 (4) ◽  
pp. 1243
Author(s):  
D. Machin ◽  
N. E. Breslow ◽  
N. E. Day
Keyword(s):  
Cancer Research ◽  
Cohort Studies ◽  
Statistical Methods

scholarly journals Variability of Prognostic Results Based on Biological Parameters in Sickle Cell Disease Cohort Studies in Children: What Should Clinicians Know?

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 143
Author(s):  
Julie Sommet ◽  
Enora Le Roux ◽  
Bérengère Koehl ◽  
Zinedine Haouari ◽  
Damir Mohamed ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Sickle Cell Disease ◽  
Cohort Studies ◽  
Statistical Methods ◽  
Sickle Cell ◽  
Biological Parameters ◽  
Analysis Method ◽  
Cell Disease ◽  
Statistical Analysis Method

Background: Many pediatric studies describe the association between biological parameters (BP) and severity of sickle cell disease (SCD) using different methods to collect or to analyze BP. This article assesses the methods used for collection and subsequent statistical analysis of BP, and how these impact prognostic results in SCD children cohort studies. Methods: Firstly, we identified the collection and statistical methods used in published SCD cohort studies. Secondly, these methods were applied to our cohort of 375 SCD children, to evaluate the association of BP with cerebral vasculopathy (CV). Results: In 16 cohort studies, BP were collected either once or several times during follow-up. The identified methods in the statistical analysis were: (1) one baseline value per patient (2) last known value; (3) mean of all values; (4) modelling of all values in a two-stage approach. Applying these four different statistical methods to our cohort, the results and interpretation of the association between BP and CV were different depending on the method used. Conclusion: The BP prognostic value depends on the chosen statistical analysis method. Appropriate statistical analyses of prognostic factors in cohort studies should be considered and should enable valuable and reproducible conclusions.

Statistical methods in cancer research

2001 ◽  
Vol 76 (3) ◽  
pp. 201-223 ◽  
Author(s):  
Pippa M. Simpson ◽  
John A. Spratt ◽  
John S. Spratt
Keyword(s):  
Cancer Research ◽  
Statistical Methods

scholarly journals Statistical Methods for Recurrent Event Analysis in Cohort Studies of CKD

2017 ◽  
Vol 12 (12) ◽  
pp. 2066-2073 ◽  
Author(s):  
Wei Yang ◽  
Christopher Jepson ◽  
Dawei Xie ◽  
Jason A. Roy ◽  
Haochang Shou ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Statistical Methods ◽  
Recurrent Event ◽  
Event Analysis
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