Errata: Hierarchical Analysis of Inbreeding Depression in Peromyscus polionotus

Evolution ◽  
1997 ◽  
Vol 51 (3) ◽  
pp. 1025 ◽  
Author(s):  
R. C. Lacy ◽  
G. Alaks ◽  
A. Walsh
Keyword(s):  
Inbreeding Depression ◽  
Hierarchical Analysis ◽  
Peromyscus Polionotus

Hierarchical Analysis of Inbreeding Depression in Peromyscus polionotus

Evolution ◽  
1996 ◽  
Vol 50 (6) ◽  
pp. 2187 ◽  
Author(s):  
Robert C. Lacy ◽  
Glen Alaks ◽  
Allison Walsh
Keyword(s):  
Inbreeding Depression ◽  
Hierarchical Analysis ◽  
Peromyscus Polionotus

scholarly journals HIERARCHICAL ANALYSIS OF INBREEDING DEPRESSION IN PEROMYSCUS POLIONOTUS

Evolution ◽  
1996 ◽  
Vol 50 (6) ◽  
pp. 2187-2200 ◽  
Author(s):  
Robert C. Lacy ◽  
Glen Alaks ◽  
Allison Walsh
Keyword(s):  
Inbreeding Depression ◽  
Hierarchical Analysis ◽  
Peromyscus Polionotus

scholarly journals High-throughput sequencing reveals inbreeding depression in a natural population

2014 ◽  
Vol 111 (10) ◽  
pp. 3775-3780 ◽  
Author(s):  
Joseph I. Hoffman ◽  
Fraser Simpson ◽  
Patrice David ◽  
Jolianne M. Rijks ◽  
Thijs Kuiken ◽  
...  
Keyword(s):  
Natural Population ◽  
Inbreeding Depression ◽  
High Throughput Sequencing ◽  
Natural Populations ◽  
Harbor Seals ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Peromyscus Polionotus ◽  
Genome Wide ◽  
Underlying Mechanisms

Proxy measures of genome-wide heterozygosity based on approximately 10 microsatellites have been used to uncover heterozygosity fitness correlations (HFCs) for a wealth of important fitness traits in natural populations. However, effect sizes are typically very small and the underlying mechanisms remain contentious, as a handful of markers usually provides little power to detect inbreeding. We therefore used restriction site associated DNA (RAD) sequencing to accurately estimate genome-wide heterozygosity, an approach transferrable to any organism. As a proof of concept, we first RAD sequenced oldfield mice (Peromyscus polionotus) from a known pedigree, finding strong concordance between the inbreeding coefficient and heterozygosity measured at 13,198 single-nucleotide polymorphisms (SNPs). When applied to a natural population of harbor seals (Phoca vitulina), a weak HFC for parasite infection based on 27 microsatellites strengthened considerably with 14,585 SNPs, the deviance explained by heterozygosity increasing almost fivefold to a remarkable 49%. These findings arguably provide the strongest evidence to date of an HFC being due to inbreeding depression in a natural population lacking a pedigree. They also suggest that under some circumstances heterozygosity may explain far more variation in fitness than previously envisaged.

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