The One-Compartment Open Model: Some Statistical Aspects of Parameter Estimation

1975 ◽  
Vol 24 (3) ◽  
pp. 309 ◽  
Author(s):  
B. E. Rodda ◽  
C. B. Sampson ◽  
D. W. Smith
Keyword(s):  
Parameter Estimation ◽  
Open Model ◽  
The One ◽  
Compartment Open Model

scholarly journals A model system for investigating the biliary excretion of an anion in the rat

1975 ◽  
Vol 148 (2) ◽  
pp. 303-307 ◽  
Author(s):  
G M Powell ◽  
J G Jones ◽  
A H Olavesen ◽  
C G Curtis
Keyword(s):  
Kinetic Analysis ◽  
Continuous Infusion ◽  
Biliary Excretion ◽  
Essential Feature ◽  
Model System ◽  
Open Model ◽  
Compartment Open Model

1. The biliary excretion of phenolphthalein di[35S]sulphate was studied in rats. 2. The conjugate was administered by continuous infusion at rates of 3, 4.5, 6, 9 and 12 mug/min, and kinetic analysis of the rate of biliary excretion was consistent with a two-compartment open-model system. 3. The results obtained after single injections of the ester were also consistent with the model. 4. An essential feature of the model is the presence of a compartment into which the ester may pass as an alternative to direct excretion via the bile. 5. It is suggested that such a compartment may be located within the liver.

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