Σ1 compactness for next admissible sets

1974 ◽  
Vol 39 (1) ◽  
pp. 105-116 ◽  
Author(s):  
Judy Green

Let σ be any sequence B0, B1 …, Bn, … of transitive sets closed under pairs with for each n. In this paper we show that the smallest admissible set Aσ with σ ∈ Aσ is Σ1 compact. Thus we have an entirely new class of explicitly describable uncountable Σ1 compact sets.The search for uncountable Σ1 compact languages goes back to Hanf's negative results on compact cardinals [7]. Barwise first showed that all countable admissible sets were Σ1 compact [1] and then went on to give a characterization of the Σ1 compact sets in terms of strict reflection [2]. While his characterization has been of interest in understanding the Σ1 compactness phenomenon it has led to the identification of only one class of uncountable Σ1 compact sets. In particular, Barwise showed [2], using the above notation, that if ⋃nBn is power set admissible it satisfies the strict reflection principle and hence is Σ1 compact. (This result was obtained independently by Karp using algebraic methods [9].)In proving our compactness theorem we follow Makkai's approach to the Barwise Compactness Theorem [12] and use a modified version of Smullyan's abstract consistency property [14]. A direct generalization of Makkai's method to the cofinality ω case yields a proof of the Barwise-Karp result mentioned above [6]. In order to obtain our new result we depart from the usual definition of language and use instead the indexed languages of Karp [9] in which a conjunction is considered to operate on a function whose range is a set of formulas rather than on a set of formulas itself.

1977 ◽  
Vol 42 (1) ◽  
pp. 33-46 ◽  
Author(s):  
Mark Nadel ◽  
Jonathan Stavi

AbstractLet ℳ be a structure for a language ℒ on a set M of urelements. HYP(ℳ) is the least admissible set above ℳ. In §1 we show that pp(HYP(ℳ)) [= the collection of pure sets in HYP(ℳ)] is determined in a simple way by the ordinal α = ° (HYP(ℳ)) and the ℒxω theory of ℳ up to quantifier rank α. In §2 we consider the question of which pure countable admissible sets are of the form pp(HYP(ℳ)) for some ℳ and show that all sets Lα (α admissible) are of this form. Other positive and negative results on this question are obtained.


2020 ◽  
Vol 20 (7) ◽  
pp. 490-500 ◽  
Author(s):  
Justin S. Becker ◽  
Amir T. Fathi

The genomic characterization of acute myeloid leukemia (AML) by DNA sequencing has illuminated subclasses of the disease, with distinct driver mutations, that might be responsive to targeted therapies. Approximately 15-23% of AML genomes harbor mutations in one of two isoforms of isocitrate dehydrogenase (IDH1 or IDH2). These enzymes are constitutive mediators of basic cellular metabolism, but their mutated forms in cancer synthesize an abnormal metabolite, 2- hydroxyglutarate, that in turn acts as a competitive inhibitor of multiple gene regulatory enzymes. As a result, leukemic IDH mutations cause changes in genome structure and gene activity, culminating in an arrest of normal myeloid differentiation. These discoveries have motivated the development of a new class of selective small molecules with the ability to inhibit the mutant IDH enzymes while sparing normal cellular metabolism. These agents have shown promising anti-leukemic activity in animal models and early clinical trials, and are now entering Phase 3 study. This review will focus on the growing preclinical and clinical data evaluating IDH inhibitors for the treatment of IDH-mutated AML. These data suggest that inducing cellular differentiation is central to the mechanism of clinical efficacy for IDH inhibitors, while also mediating toxicity for patients who experience IDH Differentiation Syndrome. Ongoing trials are studying the efficacy of IDH inhibitors in combination with other AML therapies, both to evaluate potential synergistic combinations as well as to identify the appropriate place for IDH inhibitors within existing standard-of-care regimens.


Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2313
Author(s):  
Maria Luisa Beconcini ◽  
Pietro Croce ◽  
Paolo Formichi ◽  
Filippo Landi ◽  
Benedetta Puccini

The evaluation of the shear behavior of masonry walls is a first fundamental step for the assessment of existing masonry structures in seismic zones. However, due to the complexity of modelling experimental behavior and the wide variety of masonry types characterizing historical structures, the definition of masonry’s mechanical behavior is still a critical issue. Since the possibility to perform in situ tests is very limited and often conflicting with the needs of preservation, the characterization of shear masonry behavior is generally based on reference values of mechanical properties provided in modern structural codes for recurrent masonry categories. In the paper, a combined test procedure for the experimental characterization of masonry mechanical parameters and the assessment of the shear behavior of masonry walls is presented together with the experimental results obtained on three stone masonry walls. The procedure consists of a combination of three different in situ tests to be performed on the investigated wall. First, a single flat jack test is executed to derive the normal compressive stress acting on the wall. Then a double flat jack test is carried out to estimate the elastic modulus. Finally, the proposed shear test is performed to derive the capacity curve and to estimate the shear modulus and the shear strength. The first results obtained in the experimental campaign carried out by the authors confirm the capability of the proposed methodology to assess the masonry mechanical parameters, reducing the uncertainty affecting the definition of capacity curves of walls and consequently the evaluation of seismic vulnerability of the investigated buildings.


2021 ◽  
pp. 1-10
Author(s):  
Narjes Firouzkouhi ◽  
Abbas Amini ◽  
Chun Cheng ◽  
Mehdi Soleymani ◽  
Bijan Davvaz

Inspired by fuzzy hyperalgebras and fuzzy polynomial function (term function), some homomorphism properties of fundamental relation on fuzzy hyperalgebras are conveyed. The obtained relations of fuzzy hyperalgebra are utilized for certain applications, i.e., biological phenomena and genetics along with some elucidatory examples presenting various aspects of fuzzy hyperalgebras. Then, by considering the definition of identities (weak and strong) as a class of fuzzy polynomial function, the smallest equivalence relation (fundamental relation) is obtained which is an important tool for fuzzy hyperalgebraic systems. Through the characterization of these equivalence relations of a fuzzy hyperalgebra, we assign the smallest equivalence relation α i 1 i 2 ∗ on a fuzzy hyperalgebra via identities where the factor hyperalgebra is a universal algebra. We extend and improve the identities on fuzzy hyperalgebras and characterize the smallest equivalence relation α J ∗ on the set of strong identities.


2021 ◽  
Vol 22 (9) ◽  
pp. 4707
Author(s):  
Mariana Lopes ◽  
Sandra Louzada ◽  
Margarida Gama-Carvalho ◽  
Raquel Chaves

(Peri)centromeric repetitive sequences and, more specifically, satellite DNA (satDNA) sequences, constitute a major human genomic component. SatDNA sequences can vary on a large number of features, including nucleotide composition, complexity, and abundance. Several satDNA families have been identified and characterized in the human genome through time, albeit at different speeds. Human satDNA families present a high degree of sub-variability, leading to the definition of various subfamilies with different organization and clustered localization. Evolution of satDNA analysis has enabled the progressive characterization of satDNA features. Despite recent advances in the sequencing of centromeric arrays, comprehensive genomic studies to assess their variability are still required to provide accurate and proportional representation of satDNA (peri)centromeric/acrocentric short arm sequences. Approaches combining multiple techniques have been successfully applied and seem to be the path to follow for generating integrated knowledge in the promising field of human satDNA biology.


Author(s):  
M. Ferrara ◽  
M. Trombetti

AbstractLet G be an abelian group. The aim of this short paper is to describe a way to identify pure subgroups H of G by looking only at how the subgroup lattice $$\mathcal {L}(H)$$ L ( H ) embeds in $$\mathcal {L}(G)$$ L ( G ) . It is worth noticing that all results are carried out in a local nilpotent context for a general definition of purity.


2012 ◽  
Vol 730-732 ◽  
pp. 569-574
Author(s):  
Marta Cabral ◽  
Fernanda Margarido ◽  
Carlos A. Nogueira

Spent Ni-MH batteries are not considered too dangerous for the environment, but they have a considerable economical value due to the chemical composition of electrodes which are highly concentrated in metals. The present work aimed at the physical and chemical characterisation of spent cylindrical and thin prismatic Ni-MH batteries, contributing for a better definition of the recycling process of these spent products. The electrode materials correspond to more than 50% of the batteries weight and contain essentially nickel and rare earths (RE), and other secondary elements (Co, Mn, Al). The remaining components are the steel parts from the external case and supporting grids (near 30%) containing Fe and Ni, and the plastic components (<10%). Elemental quantitative analysis showed that the electrodes are highly concentrated in metals. Phase identification by X-ray powder diffraction combined with chemical analysis and leaching experiments allowed advancing the electrode materials composition. The cathode is essentially constituted by 6% metallic Ni, 66% Ni(OH)2, 4.3% Co(OH)2 and the anode consists mainly in 62% RENi5 and 17% of substitutes and/or additives such as Co, Mn and Al.


2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Lyudmila P. Trenozhnikova ◽  
Almagul K. Khasenova ◽  
Assya S. Balgimbaeva ◽  
Galina B. Fedorova ◽  
Genrikh S. Katrukha ◽  
...  

We describe the actinomycete strain IMV-70 isolated from the soils of Kazakhstan, which produces potent antibiotics with high levels of antibacterial activity. After the research of its morphological, chemotaxonomic, and cultural characteristics, the strain with potential to be developed further as a novel class of antibiotics with chemotherapeutics potential was identified asStreptomycessp. IMV-70. In the process of fermentation, the strainStreptomycesspp. IMV-70 produces the antibiotic no. 70, which was isolated from the culture broth by extraction with organic solvents. Antibiotic compound no. 70 was purified and separated into individual components by HPLC, TLC, and column chromatography methods. The main component of the compound is the antibiotic 70-A, which was found to be identical to the peptolide etamycin A. Two other antibiotics 70-B and 70-C have never been described and therefore are new antibiotics. The physical-chemical and biological characteristics of these preparations were described and further researched. Determination of the optimal growth conditions to cultivate actinomycete-producer strain IMV-70 and development of methods to isolate, purify, and accumulate preparations of the new antibiotic no. 70 enable us to research further the potential of this new class of antibiotics.


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