Experimental Studies in Adult Learning and Memory

1977 ◽  
Vol 48 (1) ◽  
pp. 110
Author(s):  
Ohmer Milton ◽  
D. Barry Lumsden ◽  
Ronald H. Sherron
Keyword(s):  
Adult Learning ◽  
Learning And Memory ◽  
Experimental Studies

Effect of Gmelina arborea on learning and memory in amnesia-induced and non-amnesia groups of albino Wistar rats

2019 ◽  
Vol 30 (5) ◽  
Author(s):  
Ravi Sori ◽  
Basavaraj Poojar ◽  
Nandan Hodlur ◽  
Priya Gandigawad
Keyword(s):  
Learning And Memory ◽  
Wistar Rats ◽  
Experimental Studies ◽  
Intellectual Ability ◽  
Screening Tests ◽  
Control Group ◽  
Significant Activity ◽  
Gmelina Arborea ◽  
Memory Processes ◽  
Anti Oxidant

Abstract Background The brain is the centre of the nervous system in all vertebrates. The central cholinergic pathways play a prominent role in learning and memory processes. Dementia is a mental disorder characterized by the loss of intellectual ability, which invariably involves the impairment of memory. The crude extracts of the Gmelina arborea plant are reported to possess wound-healing, anti-diarrheal, anti-oxidant, anti-diabetic, and anti-ulcer property. The present study was designed to evaluate the effects of G. arborea on learning and memory in albino Wistar rats. Methods A total of 36 healthy rats were selected for the study, which were divided in to six groups. Standard screening tests such as the elevated plus maze (EPM), Morris water maze (MWM), and step-down passive avoidance (SDA) tests were used for testing the learning and memory processes. Results Gmelina arborea at higher doses (1000 mg/kg) showed statistically significant activity in EPM, MWM, and SDA tests for assessing the learning and memory paradigms when compared to the control group in amnesia-induced and non-amnesia groups of rats. Conclusions This is the first ever study to report the effects of G. arborea on learning and memory in both amnesia-induced and non-amnesia groups of rats. Our results show that G. arborea potentiates the processes of learning and memory. The observed pharmacological activities should be further evaluated by detailed experimental studies and revalidated by clinical trials.

scholarly journals A role for 5-HT4 receptors in human learning and memory

2019 ◽  
pp. 1-9 ◽  
Author(s):  
Susannah E. Murphy ◽  
Lucy C. Wright ◽  
Michael Browning ◽  
Philip J. Cowen ◽  
Catherine J. Harmer
Keyword(s):  
Healthy Volunteers ◽  
Learning And Memory ◽  
Emotional Processing ◽  
Verbal Learning ◽  
Experimental Studies ◽  
Memory Task ◽  
Learning Task ◽  
Emotional Memory ◽  
Receptor Activation ◽  
Human Cognition

AbstractBackground5-HT4 receptor stimulation has pro-cognitive and antidepressant-like effects in animal experimental studies; however, this pharmacological approach has not yet been tested in humans. Here we used the 5-HT4 receptor partial agonist prucalopride to assess the translatability of these effects and characterise, for the first time, the consequences of 5-HT4 receptor activation on human cognition and emotion.MethodsForty one healthy volunteers were randomised, double-blind, to a single dose of prucalopride (1 mg) or placebo in a parallel group design. They completed a battery of cognitive tests measuring learning and memory, emotional processing and reward sensitivity.ResultsPrucalopride increased recall of words in a verbal learning task, increased the accuracy of recall and recognition of words in an incidental emotional memory task and increased the probability of choosing a symbol associated with a high likelihood of reward or absence of loss in a probabilistic instrumental learning task. Thus acute prucalopride produced pro-cognitive effects in healthy volunteers across three separate tasks.ConclusionsThese findings are a translation of the memory enhancing effects of 5-HT4 receptor agonism seen in animal studies, and lend weight to the idea that the 5-HT4 receptor could be an innovative target for the treatment of cognitive deficits associated with depression and other neuropsychiatric disorders. Contrary to the effects reported in animal models, prucalopride did not reveal an antidepressant profile in human measures of emotional processing.

Sign in / Sign up

Export Citation Format

Share Document