Multiple Drug-Resistant Salmonella typhimurium DT104 and DT104b Isolated in Bobwhite Quail (Colinus virginianus)

1999 ◽  
Vol 43 (4) ◽  
pp. 788 ◽  
Author(s):  
Julie D. Helm ◽  
Raymond K. Hines ◽  
Joseph E. Hill ◽  
John A. Caver
Keyword(s):  
Salmonella Typhimurium ◽  
Colinus Virginianus ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Bobwhite Quail ◽  
Multiple Drug Resistant

scholarly journals Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype

2009 ◽  
Vol 19 (12) ◽  
pp. 2279-2287 ◽  
Author(s):  
R. A. Kingsley ◽  
C. L. Msefula ◽  
N. R. Thomson ◽  
S. Kariuki ◽  
K. E. Holt ◽  
...  
Keyword(s):  
Salmonella Typhimurium ◽  
Invasive Disease ◽  
Sub Saharan Africa ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Distinct Genotype ◽  
Multiple Drug Resistant ◽  
Sub Saharan

scholarly journals Trend of multiple drug resistant Salmonella Typhimurium in Norway

2002 ◽  
Vol 7 (1) ◽  
pp. 5-7 ◽  
Author(s):  
O Alvseike ◽  
T Leegaard ◽  
P Aavitsland ◽  
J Lassen
Keyword(s):  
Salmonella Typhimurium ◽  
Phage Type ◽  
Multidrug Resistant ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Secondary Infections ◽  
Multiple Drug Resistant

This article reports the trend of multidrug resistant Salmonella Typhimurium isolated from humans in Norway from 1998 to 2000. Most of the incidents with multiple resistant S. Typhimurium infection contracted in Norway have been DT104. We should therefore expect an increase of both primary and secondary infections if strains such as phage type DT104 with R-type ACSSuT become endemic.

Multiple drug-resistant strains of Salmonella typhimurium in poultry

1989 ◽  
Vol 124 (20) ◽  
pp. 538-538 ◽  
Author(s):  
E. Threlfall ◽  
D. Brown ◽  
B. Rowe ◽  
L. Ward
Keyword(s):  
Salmonella Typhimurium ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant ◽  
Resistant Strains ◽  
Drug Resistant Strains

scholarly journals trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zachary D. Aron ◽  
Atousa Mehrani ◽  
Eric D. Hoffer ◽  
Kristie L. Connolly ◽  
Pooja Srinivas ◽  
...  
Keyword(s):  
Oral Dose ◽  
Neisseria Gonorrhoeae ◽  
Multiple Drug ◽  
Specific Inhibition ◽  
Drug Resistant ◽  
Peptidyl Transfer ◽  
Bacterial Ribosome ◽  
Multiple Drug Resistant ◽  
Unique Site

AbstractBacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery of a family of acylaminooxadiazoles that selectively inhibit trans-translation, the main ribosome rescue pathway in bacteria. Here, we report optimization of the pharmacokinetic and antibiotic properties of the acylaminooxadiazoles, producing MBX-4132, which clears multiple-drug resistant Neisseria gonorrhoeae infection in mice after a single oral dose. Single particle cryogenic-EM studies of non-stop ribosomes show that acylaminooxadiazoles bind to a unique site near the peptidyl-transfer center and significantly alter the conformation of ribosomal protein bL27, suggesting a novel mechanism for specific inhibition of trans-translation by these molecules. These results show that trans-translation is a viable therapeutic target and reveal a new conformation within the bacterial ribosome that may be critical for ribosome rescue pathways.

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