Cellular and Humoral Response of in Ovo-Bursectomized Chickens to Experimental Challenge with Velogenic Newcastle Disease Virus

1987 ◽  
Vol 31 (2) ◽  
pp. 293 ◽  
Author(s):  
Olga C. Marino ◽  
Robert P. Hanson
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Humoral Response ◽  
In Ovo ◽  
Velogenic Newcastle Disease Virus ◽  
Experimental Challenge

scholarly journals Newcastle Disease Viruses Causing Recent Outbreaks Worldwide Show Unexpectedly High Genetic Similarity to Historical Virulent Isolates from the 1940s

2016 ◽  
Vol 54 (5) ◽  
pp. 1228-1235 ◽  
Author(s):  
Kiril M. Dimitrov ◽  
Dong-Hun Lee ◽  
Dawn Williams-Coplin ◽  
Timothy L. Olivier ◽  
Patti J. Miller ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Rna Virus ◽  
Phylogenetic Analyses ◽  
Genetic Distances ◽  
Wild Birds ◽  
Rates Of Change ◽  
Virulent Strains ◽  
Experimental Challenge

Virulent strains of Newcastle disease virus (NDV) cause Newcastle disease (ND), a devastating disease of poultry and wild birds. Phylogenetic analyses clearly distinguish historical isolates (obtained prior to 1960) from currently circulating viruses of class II genotypes V, VI, VII, and XII through XVIII. Here, partial and complete genomic sequences of recent virulent isolates of genotypes II and IX from China, Egypt, and India were found to be nearly identical to those of historical viruses isolated in the 1940s. Phylogenetic analysis, nucleotide distances, and rates of change demonstrate that these recent isolates have not evolved significantly from the most closely related ancestors from the 1940s. The low rates of change for these virulent viruses (7.05 × 10−5and 2.05 × 10−5per year, respectively) and the minimal genetic distances existing between these and historical viruses (0.3 to 1.2%) of the same genotypes indicate an unnatural origin. As with any other RNA virus, Newcastle disease virus is expected to evolve naturally; thus, these findings suggest that some recent field isolates should be excluded from evolutionary studies. Furthermore, phylogenetic analyses show that these recent virulent isolates are more closely related to virulent strains isolated during the 1940s, which have been and continue to be used in laboratory and experimental challenge studies. Since the preservation of viable viruses in the environment for over 6 decades is highly unlikely, it is possible that the source of some of the recent virulent viruses isolated from poultry and wild birds might be laboratory viruses.

scholarly journals Evaluation of a thermostable Newcastle disease virus strain TS09-C as an in-ovo vaccine for chickens

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0172812 ◽  
Author(s):  
Guoyuan Wen ◽  
Lintao Li ◽  
Qingzhong Yu ◽  
Hongling Wang ◽  
Qingping Luo ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Virus Strain ◽  
Newcastle Disease ◽  
Newcastle Disease Virus Strain ◽  
In Ovo

scholarly journals Characterization and comparison of the pathogenicity of viscerotropic velogenic Newcastle disease virus isolates in Korea

2012 ◽  
Vol 52 (4) ◽  
pp. 213-221
Author(s):  
Jae-Hong Kim ◽  
Haan-Woo Sung ◽  
Il-Hwan Kim ◽  
Eun-Kyoung Lee ◽  
Kang-Seuk Choi ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Velogenic Newcastle Disease Virus ◽  
Virus Isolates

scholarly journals Evaluation of immunity and protection in chicken administered a developed vaccine against predominant Middle Eastern strains of genotypes VI and VII of velogenic Newcastle Disease Virus

2020 ◽  
Author(s):  
Soonham Sami Yaghmoor` ◽  
Taha Abdullah Kumosani ◽  
Elie Kamil Barbour ◽  
Othman Abubaker Baothman
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Humoral Immunity ◽  
Newcastle Disease ◽  
Middle Eastern ◽  
Economic Losses ◽  
Bivalent Vaccine ◽  
Velogenic Newcastle Disease Virus ◽  
Ifn Γ ◽  
H Protein

Abstract Background The velogenic-Newcastle Disease Virus (v-NDV) causes an important disease in chicken, associated with serious economic losses to the global poultry industry. This research evaluated the immunity in broilers administered a developed bivalent vaccine, aiming at protection against predominant Middle Eastern strains of genotypes VI and VII of v-NDV. The completely randomized design implemented in this evaluation included eight treatments, differing in birds being administered or deprived of the developed vaccine, with a difference in type of challenge, either by v-NDV strain(s) of genotype VI, VII, or both. Vaccination was administered subcutaneously at 6 and 21 d of age, followed by an intra-pectoral challenge at the age of 28 d. Results The acquired humoral immunity by vaccinated and challenged birds to Hemagglutinin (H) protein was the highest at market age of 40 d, compared to challenged birds deprived of vaccination, and to vaccinates deprived of challenge (P<0.05). The same statistical difference pattern was obtained by the cell-mediated immunity (CMI), represented by birds’ level of serum IFN- γ . The type of challenge by either strain(s) of genotype VI, VII, or VI+VII did affect statistically the cross reactivity of acquired humoral immunity specific to H protein of homologous versus heterologous strains. The absence of humoral immunity and the low IFN- γ levels at 28 d of age in challenged birds deprived of vaccination lead to highest mortality, and lowest performance compared to vaccinates and challenged, vaccinates and deprived of challenge, and unvaccinated-unchallenged birds (P<0.05). Conclusions The developed bivalent vaccine was able to induce enough humoral and CMI responses, enabling protection of the broilers against production losses by each of the three types of v-NDV challenges. It is recommended to conduct future studies to evaluate such types of vaccines in chicken breeders and commercial layers, reared in various world’s zones with existing endemicity of v-NDV.

Cormorants as Potential Victims and Reservoirs of Velogenic Newcastle Disease Virus (Orthoavulavirus-1) in Central Asia

2019 ◽  
Vol 63 (4) ◽  
pp. 599
Author(s):  
Kobey Karamendin ◽  
Aidyn Kydyrmanov ◽  
Yermukhammet Kasymbekov ◽  
Klara Daulbayeva ◽  
Elizaveta Khan ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Central Asia ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Velogenic Newcastle Disease Virus
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