Divergent Selection of Chickens for Antibody Response to Sheep Erythrocytes: Kinetics of Primary and Secondary Immunizations

1985 ◽  
Vol 29 (2) ◽  
pp. 347 ◽  
Author(s):  
C. O. Ubosi ◽  
E. A. Dunnington ◽  
W. B. Gross ◽  
P. B. Siegel
Keyword(s):  
Antibody Response ◽  
Divergent Selection ◽  
Sheep Erythrocytes ◽  
Kinetics Of ◽  
Selection Of

scholarly journals Replicated Divergent Selection of Broiler Chickens for High or Low Early Antibody Response to Escherichia coli Vaccination

1992 ◽  
Vol 71 (1) ◽  
pp. 27-37 ◽  
Author(s):  
GABRIEL LEITNER ◽  
ZAHAVA UNI ◽  
AVIGDOR CAHANER ◽  
MICHAL GUTMAN ◽  
E. DAN HELLER
Keyword(s):  
Escherichia Coli ◽  
Antibody Response ◽  
Broiler Chickens ◽  
Divergent Selection ◽  
Selection Of

Elaboration and Characterization of the Properties of Refractory Cr Base Alloys

2010 ◽  
Vol 72 ◽  
pp. 46-52 ◽  
Author(s):  
Laurent Royer ◽  
Stéphane Mathieu ◽  
Christophe Liebaut ◽  
Pierre Steinmetz
Keyword(s):  
Mechanical Properties ◽  
Melting Point ◽  
Molten Glass ◽  
Energy Production ◽  
Creep Properties ◽  
Refractory Alloys ◽  
Industrial Use ◽  
Kinetics Of ◽  
Selection Of

For energy production and also for the glass industry, finding new refractory alloys which could permit to increase the process temperatures to 1200°C or more is a permanent challenge. Chromium base alloys can be good candidates, considering the melting point of Cr itself, and also its low corrosion rate in molten glass. Two families of alloys have been studied for this purpose, Cr-Mo-W and Cr-Ta-X alloys (X= Mo, Si..). A finer selection of compositions has been done, to optimize their chemical and mechanical properties. Kinetics of HT oxidation by air, of corrosion by molten glass and also creep properties of several alloys have been measured up to 1250°C. The results obtained with the best alloys (Cr-Ta base) give positive indications as regards the possibility of their industrial use.

scholarly journals Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL.

1996 ◽  
Vol 184 (2) ◽  
pp. 485-492 ◽  
Author(s):  
M A Alexander-Miller ◽  
G R Leggatt ◽  
A Sarin ◽  
J A Berzofsky
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocyte ◽  
Target Cells ◽  
High Dose ◽  
High Avidity ◽  
Apoptotic Pathway ◽  
Peptide Antigen ◽  
Kinetics Of ◽  
Selection Of

Experimental data suggest that negative selection of thymocytes can occur as a result of supraoptimal antigenic stimulation. It is unknown, however, whether such mechanisms are at work in mature CD8+ T lymphocytes. Here, we show that CD8+ effector cytotoxic T lymphocytes (CTL) are susceptible to proliferative inhibition by high dose peptide antigen, leading to apoptotic death mediated by TNF-alpha release. Such inhibition is not reflected in the cytolytic potential of the CTL, since concentrations of antigen that are inhibitory for proliferation promote efficient lysis of target cells. Thus, although CTL have committed to the apoptotic pathway, the kinetics of this process are such that CTL function can occur before death of the CTL. The concentration of antigen required for inhibition is a function of the CTL avidity, in that concentrations of antigen capable of completely inhibiting high avidity CTL maximally stimulate low avidity CTL. Importantly, the inhibition can be detected in both activated and resting CTL. Blocking studies demonstrate that the CD8 molecule contributes significantly to the inhibitory signal as the addition of anti-CD8 antibody restores the proliferative response. Thus, our data support the model that mature CD8+ CTL can accommodate an activation signal of restricted intensity, which, if surpassed, results in deletion of that cell.

Kinetics of circulating antibody response toTrichomonas vaginalis: clinical and diagnostic implications: Table 1

2015 ◽  
Vol 91 (8) ◽  
pp. 561-563 ◽  
Author(s):  
Phuong Anh Ton Nu ◽  
Paola Rappelli ◽  
Daniele Dessì ◽  
Vu Quoc Huy Nguyen ◽  
Pier Luigi Fiori
Keyword(s):  
Antibody Response ◽  
Kinetics Of ◽  
Circulating Antibody

Mechanodestruction of Isoprene Rubber. Part 1. Process Kinetics

2021 ◽  
Vol 80 (3) ◽  
pp. 118-122
Author(s):  
V.P. Dorozhkin ◽  
◽  
E.G. Mokhnatkina ◽  
D.N. Zemsky ◽  
A.D. Valiev ◽  
...  
Keyword(s):  
Experimental Data ◽  
Molecular Mass ◽  
Rate Constants ◽  
Oxidative Destruction ◽  
Process Kinetics ◽  
Mass Fractions ◽  
Rubber Part ◽  
Kinetics Of ◽  
Selection Of ◽  
Isoprene Rubber

A method is proposed that allows us to obtain the values of the rate constants (CR) of the processes of mechanodestruction (mechanical cracking) of kм, oxidative destruction of kо, and recombination of kр macromolecules, as well as the mass fractions of the corresponding fractions of φм, φо, and φр,r involved in the plasticization process (P) of SKI-3 isoprene rubber. The method is based on the selection of the values of these parameters that correspond to the previously obtained experimental data, using the previously obtained recurrent equations and a specially developed program. The dependences of the CR on the time P at 30oC are obtained, which allows us to describe the kinetics of the processes accompanying P at this temperature, and the changes in molecular mass (MM) in this process. It is shown that constant values of CR are established at large times of P. Refined explanations of the nature of the kinetics of the CR change at P are proposed. The MM value of SKI-3 macromolecules that have not undergone destruction is calculated, depending on the time of plasticization.

Kinetics of the local and systemic antibody response to primary and secondary infection with S48 Toxoplasma gondii in sheep

1995 ◽  
Vol 112 (1) ◽  
pp. 53-62 ◽  
Author(s):  
J.M. Wastling ◽  
D. Harkins ◽  
S. Maley ◽  
E. Innes ◽  
W. Panton ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Antibody Response ◽  
Secondary Infection ◽  
Kinetics Of

scholarly journals SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike

2020 ◽  
Author(s):  
Jenna J. Guthmiller ◽  
Olivia Stovicek ◽  
Jiaolong Wang ◽  
Siriruk Changrob ◽  
Lei Li ◽  
...  
Keyword(s):  
Antibody Response ◽  
B Cell ◽  
Cell Response ◽  
Nucleocapsid Protein ◽  
Antigen Specificity ◽  
Memory B Cell ◽  
Reading Frame ◽  
Global Pandemic ◽  
Kinetics Of ◽  
B Cell Response

ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a global pandemic. The antigen specificity and kinetics of the antibody response mounted against this novel virus are not understood in detail. Here, we report that subjects with a more severe SARS-CoV-2 infection exhibit a larger antibody response against the spike and nucleocapsid protein and epitope spreading to subdominant viral antigens, such as open reading frame 8 and non-structural proteins. Subjects with a greater antibody response mounted a larger memory B cell response against the spike, but not the nucleocapsid protein. Additionally, we revealed that antibodies against the spike are still capable of binding the D614G spike mutant and cross-react with the SARS-CoV-1 receptor binding domain. Together, this study reveals that subjects with a more severe SARS-CoV-2 infection exhibit a greater overall antibody response to the spike and nucleocapsid protein and a larger memory B cell response against the spike.

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