In Vitro Biosynthesis of Fatty Acids of Blood Lipids from Ducks Infected with Plasmodium lophurae

1973 ◽  
Vol 17 (3) ◽  
pp. 617
Author(s):  
K. S. Mandhare ◽  
G. T. Dimopoullos ◽  
L. T. Hart
Keyword(s):  
Fatty Acids ◽  
Blood Lipids ◽  
Plasmodium Lophurae ◽  
In Vitro Biosynthesis

FATTY ACID, CHOLESTEROL, AND ACETOACETATE BIOSYNTHESIS IN LIVER HOMOGENATES FROM NORMAL AND STARVED GUINEA PIGS

1960 ◽  
Vol 38 (1) ◽  
pp. 635-641
Author(s):  
Frank Sauer
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Guinea Pigs ◽  
Liver Homogenates ◽  
In Vitro Biosynthesis

Fatty acid, cholesterol, and acetoacetate biosynthesis was studied with liver homogenates from normal and starved guinea pigs. Starvation suppressed the incorporation of acetate into fatty acids and cholesterol but not into acetoacetate. The in vitro biosynthesis of cholesterol and fatty acids was not restored by the addition of either G-6-P or isocitrate in combination with TPN, nor was it restored by orally dosing the starved animals with dextrose. The addition of isocitrate to normal homogenates depressed cholesterogenesis and stimulated lipogenesis.

FATTY ACID, CHOLESTEROL, AND ACETOACETATE BIOSYNTHESIS IN LIVER HOMOGENATES FROM NORMAL AND STARVED GUINEA PIGS

1960 ◽  
Vol 38 (7) ◽  
pp. 635-641 ◽  
Author(s):  
Frank Sauer
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Guinea Pigs ◽  
Liver Homogenates ◽  
In Vitro Biosynthesis

Fatty acid, cholesterol, and acetoacetate biosynthesis was studied with liver homogenates from normal and starved guinea pigs. Starvation suppressed the incorporation of acetate into fatty acids and cholesterol but not into acetoacetate. The in vitro biosynthesis of cholesterol and fatty acids was not restored by the addition of either G-6-P or isocitrate in combination with TPN, nor was it restored by orally dosing the starved animals with dextrose. The addition of isocitrate to normal homogenates depressed cholesterogenesis and stimulated lipogenesis.

In Vitro Biosynthesis of Lipids in Blood from Ducks Infected with Plasmodium Lophurae *

1969 ◽  
Vol 18 (5) ◽  
pp. 657-661 ◽  
Author(s):  
William G. Brundage ◽  
Christopher Marie Hyland ◽  
G. T. Dimopoullos
Keyword(s):  
Plasmodium Lophurae ◽  
In Vitro Biosynthesis

In vitro biosynthesis of fatty acids inDrosophila melanogaster

Lipids ◽  
1967 ◽  
Vol 2 (5) ◽  
pp. 429-431 ◽  
Author(s):  
Alec D. Keith ◽  
Gerd Gauslaa ◽  
Beverly S. Anderson
Keyword(s):  
Fatty Acids ◽  
In Vitro Biosynthesis

Effects of the Tibetan herbal preparation PADMA 28 on blood lipids and lipid oxidisability in subjects with mild hypercholesterolaemia

VASA ◽  
2005 ◽  
Vol 34 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Brunner-La Rocca ◽  
Schindler ◽  
Schlumpf ◽  
Saller ◽  
Suter
Keyword(s):  
Endothelial Dysfunction ◽  
Blood Lipids ◽  
Ex Vivo ◽  
Hdl Cholesterol ◽  
Blood Lipid ◽  
Tibetan Medicine ◽  
Double Blind ◽  
Intraarterial Infusion ◽  
Padma 28

Background: Previous studies showed an anti-atherosclerotic effect of PADMA 28, an herbal formula based on Tibetan medicine. As the mechanisms of action are not fully understood, we investigated whether PADMA 28 may lower blood lipids and lipid oxidisability, and affect early endothelial dysfunction. Patients and methods: Sixty otherwise healthy subjects with total cholesterol ≥5.2 mmol/l and < 8.0 mmol/l were randomly assigned to placebo or PADMA 28, 3 x 2 capsules daily, for 4 weeks (double-blind). Blood lipids (total, LDL-, and HDL-cholesterol, triglycerides, Apo-lipoprotein A1 and B) and ex vivo lipid oxidisability were measured before and after treatment. In a subset of 24 subjects, endothelial function was assessed using venous occlusion plethysmography with intraarterial infusion of acetylcholine. Isolated LDL and plasma both untreated and pre-treated with PADMA 28 extract were oxidised by the radical generator AAPH. Conjugated diene formation was measured at 245 nm. Results: Blood lipids did not change during the study in both groups. In contrast to previous reports in mild hypercholesterolaemia, no endothelial dysfunction was seen and, consequently, was not influenced by therapy. Ex vivo blood lipid oxidisability was significantly reduced with PADMA 28 (area under curve: 5.29 ± 1.62 to 4.99 ± 1.46, p = 0.01), and remained unchanged in the placebo group (5.33 ± 1.88 to 5.18 ± 1.78, p > 0.1). This effect persisted one week after cessation of medication. In vitro experiments confirmed the prevention of lipid peroxidation in the presence of PADMA 28 extracts. Persistent protection was also seen for LDL isolated from PADMA 28-pretreated blood after being subjected to rigorous purification. Conclusions: This study suggests that the inhibition of blood lipid oxidisability by PADMA 28 may play a role in its anti-atherosclerotic effect.

Short-Chain Fatty Acids Prevent Diabetic Nephropathy In Vivo and In Vitro

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 92-OR ◽  
Author(s):  
WEI HUANG ◽  
YONG XU ◽  
YOUHUA XU ◽  
LUPING ZHOU ◽  
CHENLIN GAO
Keyword(s):  
Fatty Acids ◽  
Diabetic Nephropathy ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids
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