A Genomics Approach to Mitochondrial Evolution

1999 ◽  
Vol 196 (3) ◽  
pp. 400-403 ◽  
Author(s):  
M. W. Gray ◽  
G. Burger ◽  
R. Cedergren ◽  
G. B. Golding ◽  
C. Lemieux ◽  
...  
Keyword(s):  
Mitochondrial Evolution

scholarly journals Molecular Phylogenetics and Mitochondrial Evolution

Life ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 4
Author(s):  
Andrea Luchetti ◽  
Federico Plazzi
Keyword(s):  
Mitochondrial Genome ◽  
Molecular Phylogenetics ◽  
Animal Kingdom ◽  
Mitochondrial Evolution

The myth of a “typical” mitochondrial genome (mtDNA) is a rock-hard belief in the field of genetics, at least for the animal kingdom [...]

scholarly journals Accelerated Mitochondrial Evolution and “Darwin's Corollary”: Asymmetric Viability of Reciprocal F1 Hybrids in Centrarchid Fishes

Genetics ◽  
2008 ◽  
Vol 178 (2) ◽  
pp. 1037-1048 ◽  
Author(s):  
Daniel I. Bolnick ◽  
Michael Turelli ◽  
Hernán López-Fernández ◽  
Peter C. Wainwright ◽  
Thomas J. Near
Keyword(s):  
F1 Hybrids ◽  
Mitochondrial Evolution ◽  
Centrarchid Fishes

Mitochondrial Evolution in HIV-Infected Children Receiving First- or Second-Generation Nucleoside Analogues

2012 ◽  
Vol 60 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Constanza Morén ◽  
Antoni Noguera-Julian ◽  
Glòria Garrabou ◽  
Marc Catalán ◽  
Núria Rovira ◽  
...  
Keyword(s):  
Second Generation ◽  
Nucleoside Analogues ◽  
Mitochondrial Evolution

scholarly journals Mitochondrial Evolution

Science ◽  
1999 ◽  
Vol 283 (5407) ◽  
pp. 1476-1481 ◽  
Author(s):  
M. W. Gray
Keyword(s):  
Mitochondrial Evolution

scholarly journals Mitochondrial Evolution

2012 ◽  
Vol 4 (9) ◽  
pp. a011403-a011403 ◽  
Author(s):  
M. W. Gray
Keyword(s):  
Mitochondrial Evolution

scholarly journals Mitogenomic analysis of a 50-generation chicken pedigree reveals a rapid rate of mitochondrial evolution and evidence for paternal mtDNA inheritance

2015 ◽  
Vol 11 (10) ◽  
pp. 20150561 ◽  
Author(s):  
Michelle Alexander ◽  
Simon Y. W. Ho ◽  
Martyna Molak ◽  
Ross Barnett ◽  
Örjan Carlborg ◽  
...  
Keyword(s):  
Point Mutations ◽  
Mitochondrial Genomes ◽  
Synonymous Mutation ◽  
Novel Mutations ◽  
Short Term ◽  
Mitochondrial Evolution ◽  
Phenotypic Differences ◽  
Mtdna Inheritance ◽  
Short Time

Mitochondrial genomes represent a valuable source of data for evolutionary research, but studies of their short-term evolution have typically been limited to invertebrates, humans and laboratory organisms. Here we present a detailed study of 12 mitochondrial genomes that span a total of 385 transmissions in a well-documented 50-generation pedigree in which two lineages of chickens were selected for low and high juvenile body weight. These data allowed us to test the hypothesis of time-dependent evolutionary rates and the assumption of strict maternal mitochondrial transmission, and to investigate the role of mitochondrial mutations in determining phenotype. The identification of a non-synonymous mutation in ND4L and a synonymous mutation in CYTB , both novel mutations in Gallus , allowed us to estimate a molecular rate of 3.13 × 10 −7 mutations/site/year (95% confidence interval 3.75 × 10 −8 –1.12 × 10 −6 ). This is substantially higher than avian rate estimates based upon fossil calibrations. Ascertaining which of the two novel mutations was present in an additional 49 individuals also revealed an instance of paternal inheritance of mtDNA. Lastly, an association analysis demonstrated that neither of the point mutations was strongly associated with the phenotypic differences between the two selection lines. Together, these observations reveal the highly dynamic nature of mitochondrial evolution over short time periods.

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