Self-Capping RNA Catalysts Derived From Selection-Amplification

1999 ◽  
Vol 196 (3) ◽  
pp. 320-321
Author(s):  
F. Huang ◽  
Z. Yang ◽  
M. Yarus
Keyword(s):  
Rna Catalysts

scholarly journals The RNA origin of transfer RNA aminoacylation and beyond

2011 ◽  
Vol 366 (1580) ◽  
pp. 2959-2964 ◽  
Author(s):  
Hiroaki Suga ◽  
Gosuke Hayashi ◽  
Naohiro Terasaka
Keyword(s):  
Amino Acids ◽  
Evolutionary History ◽  
Transfer Rna ◽  
Translation System ◽  
Rna Sequences ◽  
Rna Molecules ◽  
Rna Catalysts ◽  
Modern System ◽  
History Of

Aminoacylation of tRNA is an essential event in the translation system. Although in the modern system protein enzymes play the sole role in tRNA aminoacylation, in the primitive translation system RNA molecules could have catalysed aminoacylation onto tRNA or tRNA-like molecules. Even though such RNA enzymes so far are not identified from known organisms, in vitro selection has generated such RNA catalysts from a pool of random RNA sequences. Among them, a set of RNA sequences, referred to as flexizymes (Fxs), discovered in our laboratory are able to charge amino acids onto tRNAs. Significantly, Fxs allow us to charge a wide variety of amino acids, including those that are non-proteinogenic, onto tRNAs bearing any desired anticodons, and thus enable us to reprogramme the genetic code at our will. This article summarizes the evolutionary history of Fxs and also the most recent advances in manipulating a translation system by integration with Fxs.

scholarly journals Bacterial group I introns: mobile RNA catalysts

Mobile DNA ◽  
2014 ◽  
Vol 5 (1) ◽  
pp. 8 ◽  
Author(s):  
Georg Hausner ◽  
Mohamed Hafez ◽  
David R Edgell
Keyword(s):  
Group I Introns ◽  
Bacterial Group ◽  
Group I ◽  
Rna Catalysts ◽  
Mobile Rna

Mobile RNA catalysts

Nature ◽  
1988 ◽  
Vol 336 (6201) ◽  
pp. 716-717 ◽  
Author(s):  
Michael R. Green
Keyword(s):  
Rna Catalysts ◽  
Mobile Rna

Hammerhead Ribozymes Containing Non-Nucleoside Linkers Are Active RNA Catalysts

1994 ◽  
Vol 116 (11) ◽  
pp. 4591-4598 ◽  
Author(s):  
D. Fu ◽  
Fritz Benseler ◽  
Larry W. McLaughlin
Keyword(s):  
Hammerhead Ribozymes ◽  
Rna Catalysts

Hammerhead-like molecules containing non-nucleoside linkers are active RNA catalysts

1993 ◽  
Vol 115 (18) ◽  
pp. 8483-8484 ◽  
Author(s):  
Fritz Benseler ◽  
Dong Jing Fu ◽  
Janos Ludwig ◽  
Larry W. McLaughlin
Keyword(s):  
Rna Catalysts

Relicts and models of the RNA world

2005 ◽  
Vol 4 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Kirsi Lehto ◽  
Alexey Karetnikov
Keyword(s):  
Rna World ◽  
Building Blocks ◽  
Life Forms ◽  
Molecular Fossils ◽  
Catalytic Rnas ◽  
Rna Catalysts ◽  
Metabolic Reactions ◽  
And Function ◽  
Mediated Catalysis

It is widely believed that the current DNA–RNA–protein-based life forms have evolved from preceding RNA–protein-based life forms, and these again, from mere RNA replicons. By rationale, it can be assumed that the early RNA replicons were fully heterotrophic in terms of obtaining all their building blocks from their environment. In the absence of protein catalysts, their essential life functions had to be mediated by simple functional structures and mechanisms, such as RNA secondary structures, RNA–RNA interactions and RNA-mediated catalysis, and possibly by catalytic minerals or clays. The central role of RNA catalysts in early life forms is supported by the fact that several catalytic RNAs still perform central biological functions in current life forms, and at least some of these may be derived as molecular relicts from the early RNA-based life. The RNA-catalysed metabolic reactions and molecular fossils are more conserved in the eukaryotic life forms than in the prokaryotes, suggesting that the linear eukaryote genomes may more closely resemble the structure and function of the early RNA replicons, than what do the circular prokaryote genomes. Present-day RNA viruses and viroids utilize ultimately simple life strategies, which may be similar to those used by the early RNA replicons. Thus, molecular and functional properties of viruses and viroids may be considered as examples or models of the structures and replication mechanisms, which might have been used for the replication of the early biopolymers.

Libraries of Multifunctional RNA Conjugates for the Selection of New RNA Catalysts

1997 ◽  
Vol 8 (6) ◽  
pp. 885-890 ◽  
Author(s):  
Felix Hausch ◽  
Andres Jäschke
Keyword(s):  
Rna Catalysts ◽  
Selection Of
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