scholarly journals NATURE AND ROLE OF PROTEINACEOUS HORMONAL FACTORS ACTING DURING PUPARIUM FORMATION IN FLIES

1974 ◽  
Vol 147 (1) ◽  
pp. 163-185 ◽  
Author(s):  
P. SIVASUBRAMANIAN ◽  
S. FRIEDMAN ◽  
G. FRAENKEL
Keyword(s):  
Hormonal Factors ◽  
Puparium Formation

scholarly journals The role of sex steroids in white adipose tissue adipocyte function

Reproduction ◽  
2017 ◽  
Vol 153 (4) ◽  
pp. R133-R149 ◽  
Author(s):  
A E Newell-Fugate
Keyword(s):  
Adipose Tissue ◽  
Sexual Dimorphism ◽  
White Adipose Tissue ◽  
Hormonal Factors ◽  
Obesity Epidemic ◽  
Health And Disease ◽  
Males And Females ◽  
Hormonal Milieu ◽  
Gender Influences

With the increasing knowledge that gender influences normal physiology, much biomedical research has begun to focus on the differential effects of sex on tissue function. Sexual dimorphism in mammals is due to the combined effects of both genetic and hormonal factors. Hormonal factors are mutable particularly in females in whom the estrous cycle dominates the hormonal milieu. Given the severity of the obesity epidemic and the fact that there are differences in the obesity rates in men and women, the role of sex in white adipose tissue function is being recognized as increasingly important. Although sex differences in white adipose tissue distribution are well established, the mechanisms affecting differential function of adipocytes within white adipose tissue in males and females remain largely understudied and poorly understood. One of the largest differences in the endocrine environment in males and females is the concentration of circulating androgens and estrogens. This review examines the effects of androgens and estrogens on lipolysis/lipogenesis, adipocyte differentiation, insulin sensitivity and adipokine production in adipocytes from white adipose tissue with a specific emphasis on the sexual dimorphism of adipocyte function in white adipose tissue during both health and disease.

scholarly journals The role of hormonal factors and endocrine therapy in ovarian cancer

2013 ◽  
Vol 1 ◽  
pp. 14-19 ◽  
Author(s):  
Krystyna Serkies ◽  
Marcin Sinacki ◽  
Jacek Jassem
Keyword(s):  
Ovarian Cancer ◽  
Endocrine Therapy ◽  
Hormonal Factors

Female Thyroid Cancer: The Role of Reproductive and Hormonal Factors in Switzerland

Oncology ◽  
1993 ◽  
Vol 50 (4) ◽  
pp. 309-315 ◽  
Author(s):  
Fabio Levi ◽  
Silvia Franceschi ◽  
Cristina Gulie ◽  
Eva Negri ◽  
Carlo La Vecchia
Keyword(s):  
Thyroid Cancer ◽  
Hormonal Factors

Role of hormonal factors in plasma K alterations in acute respiratory and metabolic alkalosis in dogs

1990 ◽  
Vol 258 (2) ◽  
pp. F305-F310
Author(s):  
H. Suzuki ◽  
A. Hishida ◽  
K. Ohishi ◽  
M. Kimura ◽  
N. Honda
Keyword(s):  
Metabolic Alkalosis ◽  
Control Level ◽  
Plasma Potassium ◽  
Respiratory Alkalosis ◽  
Plasma Norepinephrine ◽  
Hormonal Factors ◽  
Control Value ◽  
Norepinephrine Concentration ◽  
Induced Alkalosis

Studies were performed on previously nephrectomized dogs to examine roles of hormonal factors in plasma potassium alterations in acute alkalosis. Respiratory and metabolic alkalosis were induced by hyperventilation and intravenous NaHCO3 or tris(hydroxymethyl)aminomethane (Tris) infusion, respectively. Respiratory and NaHCO3-induced alkalosis provoked decreases in plasma potassium from the control value of 5.12 +/- 0.68 (SE) to 4.21 +/- 0.55 meq/l (P less than 0.01) and from 4.65 +/- 0.26 to 3.91 +/- 0.16 meq/l (P less than 0.01) within 180 min, respectively. In contrast, Tris-induced alkalosis elicited an increase in plasma potassium from the control value of 4.56 +/- 0.30 to 5.31 +/- 0.30 meq/l (P less than 0.01). Hypokalemia in respiratory alkalosis was associated with a decrease in the plasma norepinephrine concentration from the control level of 377 +/- 104 to 155 +/- 41 pg/ml (P less than 0.05) but not with changes in plasma levels of epinephrine, insulin, glucagon, cortisol, and aldosterone. However, this hypokalemia was not affected by phentolamine. Also, somatostatin did not modify the hypokalemic response. NaHCO3-induced hypokalemia was associated with a decline in the plasma aldosterone and norepinephrine concentrations. The decline in plasma norepinephrine in NaHCO3-induced alkalosis followed the decrease in plasma potassium. In Tris-induced alkalosis, plasma insulin increased but norepinephrine decreased. The findings do not suggest fundamental roles of the hormonal factors in the plasma potassium alterations in bilaterally nephrectomized dogs with acute alkalosis.

scholarly journals Temperature Effects on Day Old Drosophila Pupae

1962 ◽  
Vol 45 (4) ◽  
pp. 777-799 ◽  
Author(s):  
Roger Milkman
Keyword(s):  
Protein Denaturation ◽  
Biological Effects ◽  
Interspecific Variation ◽  
Temperature Adaptation ◽  
After Puparium Formation ◽  
Present Context ◽  
Rapid Temperature ◽  
Puparium Formation ◽  
Elliptical Holes

Day old Drosophila pupae were subjected to a variety of closely controlled temperature shocks. Twenty-five hours after puparium formation (at 23°), temperatures from 39.5–41.5° (Q1 = 2.3) differentially disturb the formation of the posterior crossvein. Three other separate treatments disturb posterior crossvein formation: treatments in the range 36.0–37.0° at 25 hours; 37.3–37.8° at 25 hours; and 39.5–41.5° at 19 hours. Certain qualitative effects are associated with certain temperatures: elliptical holes are seen in wings of flies exposed 25 hours after puparium formation to temperatures from 37.3–37.8°. Anterior crossvein defects ensue if animals are similarly exposed to temperatures from 37.9–38.2°. Within the physiological range, animals raised at higher temperatures are more resistant to the effects of temperatures at 39.5–41.5°. An extremely rapid temperature adaptation by exposures to temperatures in the range 31–38° results in markedly greater resistance to heat shock; here resistance to production of crossvein defects increases faster than to death. The association between qualitative effects and treatment temperatures is modified by changing the temperature at which the animals spend their first day of pupal life. Summation experiments support conclusions drawn from the simpler experiments. Genetic variation and interspecific variation are discussed in the present context, as well as implications of the role of protein denaturation in the biological effects of high temperatures and further, more general experiments.

scholarly journals Pregnancy, sex and hormonal factors in multiple sclerosis

2014 ◽  
Vol 20 (5) ◽  
pp. 527-536 ◽  
Author(s):  
David H Miller ◽  
Franz Fazekas ◽  
Xavier Montalban ◽  
Stephen C Reingold ◽  
Maria Trojano
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Course ◽  
Future Research ◽  
Comprehensive Understanding ◽  
Hormonal Factors ◽  
Disease Mechanisms ◽  
Pubmed Search ◽  
Disease Modifying ◽  
The Impact

Background: Multiple sclerosis (MS) is influenced by pregnancy, sex and hormonal factors. Objectives: A comprehensive understanding of the role of pregnancy, sex and hormonal factors can provide insights into disease mechanisms, and new therapeutic developments and can provide improved patient care and treatment. Methods: Based on an international conference of experts and a comprehensive PubMed search for publications on these areas in MS, we provide a review of what is known about the impact of these factors on disease demographics, etiology, pathophysiology and clinical course and outcomes. Results and conclusions: Recommendations are provided for counseling and management of people with MS before conception, during pregnancy and after delivery. The use of disease-modifying and symptomatic therapies in pregnancy is problematic and such treatments are normally discontinued. Available knowledge about the impact of treatment on the mother, fetus and newborn is discussed. Recommendations for future research to fill knowledge gaps and clarify inconsistencies in available data are made.

Effect of irradiation on metabolism of desoxynucleosides and role of hormonal factors in changes in their tissue and urine levels

1968 ◽  
Vol 66 (1) ◽  
pp. 770-771
Author(s):  
T. A. Fedorova ◽  
V. K. Mazurik ◽  
M. A. Lomova ◽  
M. M. Skurikhina ◽  
E. M. Belyaeva ◽  
...  
Keyword(s):  
Hormonal Factors ◽  
Urine Levels
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