FURTHER STUDIES ON THE EFFECT OF VARIATIONS IN THE TEMPERATURE ON ANIMAL TISSUES

ARTHUR W. GREELEY

doi:10.2307/1535827

Is the Expression of Deoxynucleoside Kinases and 5'-nucleotidases in Animal Tissues Related to the Biological Effects of Nucleoside Analogs?

Current Medicinal Chemistry ◽

10.2174/0929867311320340004 ◽

2013 ◽

Vol 20 (34) ◽

pp. 4241-4248 ◽

Cited By ~ 9

Author(s):

Staffan Eriksson

Keyword(s):

Biological Effects ◽

Nucleoside Analogs ◽

Animal Tissues

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A Brief Introduction to Porphyrin Compounds Used in Tumor Imaging and Therapies

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557520999201209212745 ◽

2020 ◽

Vol 20 ◽

Author(s):

Lili Pan ◽

Yu Ma ◽

Xiaoai Wu ◽

Huawei Cai ◽

Feng Qin ◽

...

Keyword(s):

Tumor Imaging ◽

Photoacoustic Imaging ◽

Therapeutic Agents ◽

Biochemical Properties ◽

Therapeutic Effects ◽

Future Prospects ◽

Animal Tissues ◽

Sonodynamic Therapy ◽

Porphyrin Derivatives ◽

Porphyrin Analogues

Abstract:: As a group of heterocyclic macrocycle organic natural compounds occurring universally in animal tissues and plants, porphyrins are composed of four modified pyrrole subunits. Porphyrin analogues/derivatives possess multiple biochemical properties because of their unique structures and have been extensively investigated in cancer treatment. Studies have shown that porphyrins and their derivatives have the ability to locate in tumor cells in a variety of human cancers, and these compounds not only exhibit potent therapeutic effects as photodynamic agents but also show promising properties in medicinal imaging, such as MRI, photoacoustic imaging, fluorescence imaging and PET/SPECT imaging. This paper reviews the recent reports of porphyrin derivatives as therapeutic agents used in tumor therapies, such as sonodynamic therapy, photodynamic therapy and radiotherapy, as well as imaging agents for multimodality tumor imaging. The limitations of porphyrin-based compounds in tumor treatments and future prospects are also summarized.

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When animals are not quite what they eat: diet digestibility influences 13C-incorporation rates and apparent discrimination in a mixed-feeding herbivore

Canadian Journal of Zoology ◽

10.1139/z11-010 ◽

2011 ◽

Vol 89 (6) ◽

pp. 453-465 ◽

Cited By ~ 36

Author(s):

Daryl Codron ◽

Jacqui Codron ◽

Matt Sponheimer ◽

Stefano M. Bernasconi ◽

Marcus Clauss

Keyword(s):

Isotope Composition ◽

Stable Carbon Isotope ◽

Food Sources ◽

Capra Hircus ◽

Stable Carbon ◽

Animal Tissues ◽

Themeda Triandra ◽

Low Protein ◽

Medicago Sativa L ◽

Discrimination Factors

The stable carbon isotope composition of animal tissues represents the weighted sum of the variety of food sources eaten. If sources differ in digestibility, tissues may overrepresent intake of more digestible items and faeces may overrepresent less digestible items. We tested this idea using whole blood and faeces of goats ( Capra hircus L., 1758) fed different food mixtures of C3 lucerne ( Medicago sativa L.) and C4 grass ( Themeda triandra Forssk.). Although blood and faecal δ13C values were broadly consistent with diet, results indicate mismatch between consumer and diet isotope compositions: both materials overrepresented the C3 (lucerne) component of diets. Lucerne had lower fibre digestibility than T. triandra, which explains the results for faeces, whereas underrepresentation of dietary C4 in blood is consistent with low protein content of the grass hay. A diet switch experiment revealed an important difference in 13C-incorporation rates across diets, which were slower for grass than lucerne diets, and in fact equilibrium states were not reached for all diets. Although more research is needed to link digestive kinetics with isotope incorporation, these results provide evidence for nonlinear relationships between consumers and their diets, invoking concerns about the conceptual value of “discrimination factors” as the prime currency for contemporary isotope ecology.

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