Positive Induction in the Acquisition and Extinction of Discrete-Trial Lever-Pressing in Rats

1980 ◽  
Vol 93 (4) ◽  
pp. 593 ◽  
Author(s):  
John R. Hovancik
Keyword(s):  
Discrete Trial ◽  
Positive Induction ◽  
Lever Pressing

Some Effects of Incremental Delay of Reward on the Discrete-Trial Lever-Pressing of Rats

1980 ◽  
Vol 93 (2) ◽  
pp. 345
Author(s):  
Patrick E. Campbell ◽  
Brian M. Kruger ◽  
Jane Holmes Steele ◽  
Patricia Eickmeyer Wood
Keyword(s):  
Discrete Trial ◽  
Lever Pressing ◽  
Delay Of Reward

Rapid Reduction of Off-Task Behavior in Retarded Children by Use of Light-Out

1985 ◽  
Vol 56 (2) ◽  
pp. 499-509 ◽  
Author(s):  
Philip W. Drash ◽  
Mary R. Murrin ◽  
Sheldon E. Jordan ◽  
Hewitt B. Clark
Keyword(s):  
Positive Reinforcement ◽  
Response Rate ◽  
Discrete Trial Training ◽  
Discrete Trial ◽  
Rapid Reduction ◽  
Therapeutic Implications ◽  
Task Behavior ◽  
Lever Pressing ◽  
Alternating Treatment Design ◽  
Treatment Design

The effectiveness of a light-out procedure in reducing periods of off-task behavior in retarded children was evaluated. Four children ages 3 to 10 yr. (mean IQ 32) were trained on a lever-pressing task as an analogue to discrete-trial training procedures. Positive reinforcement sessions were alternated with concurrent escape/avoidance procedures during which light-out was contingent upon nonresponding in an alternating treatment design. The light-out contingency rapidly and effectively reduced the length of time off-task and slightly increased response rate. Educational and therapeutic implications for retarded and autistic children include adaptation of the procedure for decreasing off-task behavior during discrete-trial training, such as in speech and language remediation.

Does Discrete Trial Teaching Trump Experimenter Differences?

2011 ◽  
Author(s):  
Marissa Dickinson ◽  
Maria Garcia ◽  
Sammantha DeMartin ◽  
Rachel Basset ◽  
Lauren Pirrmann
Keyword(s):  
Discrete Trial Teaching ◽  
Discrete Trial

Apomorphine Disrupts Discrete-Trial Delayed Spatial Alternation in Rats

2008 ◽  
Author(s):  
Jennifer Kleier ◽  
Molly S. Griffith ◽  
Mark E. Bardgett
Keyword(s):  
Discrete Trial ◽  
Spatial Alternation

scholarly journals Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats

2021 ◽  
Vol 22 (5) ◽  
pp. 2397
Author(s):  
Chrysostomos Charalambous ◽  
Tereza Havlickova ◽  
Marek Lapka ◽  
Nina Puskina ◽  
Romana Šlamberová ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Fixed Ratio ◽  
Place Preference ◽  
Self Administration ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Ghrelin Receptor ◽  
Addiction Therapy ◽  
Significant Efficacy ◽  
Lever Pressing

Cannabis/cannabinoids are widely used for recreational and therapy purposes, but their risks are largely disregarded. However, cannabinoid-associated use disorders and dependence are alarmingly increasing and an effective treatment is lacking. Recently, the growth hormone secretagogue receptor (GHSR1A) antagonism was proposed as a promising mechanism for drug addiction therapy. However, the role of GHS-R1A and its endogenous ligand ghrelin in cannabinoid abuse remains unclear. Therefore, the aim of our study was to investigate whether the GHS-R1A antagonist JMV2959 could reduce the tetrahydrocannabinol (THC)-induced conditioned place preference (CPP) and behavioral stimulation, the WIN55,212-2 intravenous self-administration (IVSA), and the tendency to relapse. Following an ongoing WIN55,212-2 self-administration, JMV2959 3 mg/kg was administered intraperitoneally 20 min before three consequent daily 120-min IVSA sessions under a fixed ratio FR1, which significantly reduced the number of the active lever-pressing, the number of infusions, and the cannabinoid intake. Pretreatment with JMV2959 suggested reduction of the WIN55,212-2-seeking/relapse-like behavior tested in rats on the twelfth day of the forced abstinence period. On the contrary, pretreatment with ghrelin significantly increased the cannabinoid IVSA as well as enhanced the relapse-like behavior. Co-administration of ghrelin with JMV2959 abolished/reduced the significant efficacy of the GHS-R1A antagonist in the cannabinoid IVSA. Pretreatment with JMV2959 significantly and dose-dependently reduced the manifestation of THC-induced CPP. The THC-CPP development was reduced after the simultaneous administration of JMV2959 with THC during conditioning. JMV2959 also significantly reduced the THC-induced behavioral stimulation in the LABORAS cage. Our findings suggest that GHS-R1A importantly participates in the rewarding/reinforcing effects of cannabinoids.

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