Audiogenic Seizures in the Laboratory Mouse

1952 ◽  
Vol 33 (1) ◽  
pp. 80 ◽  
Author(s):  
Hubert Frings ◽  
Mable Frings
Keyword(s):  
Laboratory Mouse ◽  
Audiogenic Seizures

scholarly journals Independent evolution towards larger body size in the distinctive Faroe Island mice

2021 ◽  
Author(s):  
Ricardo Wilches ◽  
William H Beluch ◽  
Ellen McConnell ◽  
Diethard Tautz ◽  
Yingguang Frank Chan
Keyword(s):  
Body Size ◽  
Meta Analysis ◽  
Small Body ◽  
Laboratory Mouse ◽  
Large Body ◽  
Natural Populations ◽  
Size Variation ◽  
Phenotypic Traits ◽  
Island Population ◽  
Multiple Loci

Abstract Most phenotypic traits in nature involve the collective action of many genes. Traits that evolve repeatedly are particularly useful for understanding how selection may act on changing trait values. In mice, large body size has evolved repeatedly on islands and under artificial selection in the laboratory. Identifying the loci and genes involved in this process may shed light on the evolution of complex, polygenic traits. Here, we have mapped the genetic basis of body size variation by making a genetic cross between mice from the Faroe Islands, which are among the largest and most distinctive natural populations of mice in the world, and a laboratory mouse strain selected for small body size, SM/J. Using this F2 intercross of 841 animals, we have identified 111 loci controlling various aspects of body size, weight and growth hormone levels. By comparing against other studies, including the use of a joint meta-analysis, we found that the loci involved in the evolution of large size in the Faroese mice were largely independent from those of a different island population or other laboratory strains. We hypothesize that colonization bottleneck, historical hybridization, or the redundancy between multiple loci have resulted in the Faroese mice achieving an outwardly similar phenotype through a distinct evolutionary path.

Wistar Audiogenic Rats (WAR) exhibit altered levels of cytokines and brain-derived neurotrophic factor following audiogenic seizures

2015 ◽  
Vol 597 ◽  
pp. 154-158 ◽  
Author(s):  
Túlio Cezar de Souza Bernardino ◽  
Antonio Lúcio Teixeira ◽  
Aline Silva Miranda ◽  
Patrícia Maia Guidine ◽  
Gustavo Rezende ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Audiogenic Seizures

Effects of Aminergic Drugs and Glutamic Acid on Audiogenic Seizures Induced by Early Exposure to Ethanol

Epilepsia ◽  
1975 ◽  
Vol 16 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Joseph Yanai ◽  
Paul Y. Sze ◽  
Benson E. Ginsburg
Keyword(s):  
Glutamic Acid ◽  
Audiogenic Seizures ◽  
Early Exposure

Audiogenic seizures induce c-fos in a model of developmental epilepsy

1992 ◽  
Vol 135 (1) ◽  
pp. 108-112 ◽  
Author(s):  
Abigail M. Snyder-Keller ◽  
Martha G. Pierson
Keyword(s):  
Audiogenic Seizures
Sign in / Sign up

Export Citation Format

Share Document