Conflict of Laws. Obligations: Contract: In General. State Where Injury Would Occur Cannot Constitutionally Apply Its Direct Action Statute to Foreign Insurance Contract with "No Action" Clause

SummaryBone marrow scintigraphy after the application of indium 111 In was compared with the results of bone marrow puncture in 18 patients with Hodgkin's disease treated with radiotherapy and/or chemotherapy. Agreement was found in 85% of the cases. When the results of bone marrow puncture were compared with the general state of haemopoiesis estimated scintigraphically agreement was found in only 65%. Bone marrow scintigraphy gives a more detailed knowledge of the general state of haemopoiesis and serves as a guide for the control of therapy with cytostatics and/or irradiation.

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Platelet Aggregation Induced in Vitro by Therapeutic Ultrasound

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651879 ◽

1977 ◽

Vol 38 (03) ◽

pp. 0640-0651 ◽

Cited By ~ 29

Author(s):

B. V Chater ◽

A. R Williams

Keyword(s):

Platelet Aggregation ◽

Direct Action ◽

Adenosine Diphosphate ◽

Ultrasonic Cavitation ◽

Related Phenomenon ◽

Release Reaction ◽

Physical Conditions ◽

Platelet Aggregates ◽

Active Substances

SummaryPlatelets were found to aggregate spontaneously when exposed to ultrasound generated by a commercial therapeutic device. At a given frequency, aggregation was found to be a dose-related phenomenon, increasing intensities of ultrasound inducing more extensive and more rapid aggregation. At any single intensity, the extent aggregation was increased as the frequency of the applied ultrasound was decreased (from 3.0 to 0.75 MHz).Ultrasound-induced platelet aggregation was found to be related to overall platelet sensitivity to adenosine diphosphate. More sensitive platelets were found to aggregate spontaneously at lower intensities of sound, and also the maximum extent of aggregation was found to be greater. Examination of ultrasound-induced platelet aggregates by electron microscopy demonstrated that the platelets had undergone the release reaction.The observation that haemoglobin was released from erythrocytes in whole blood irradiated under identical physical conditions suggests that the platelets are being distrupted by ultrasonic cavitation (violent gas/bubble oscillation).It is postulated that overall platelet aggregation is the result of two distinct effects. Firstly, the direct action of ultrasonic cavitation disrupts a small proportion of the platelet population, resulting in the liberation of active substances. These substances produce aggregation, both directly and indirectly by inducing the physiological release reaction in adjacent undamaged platelets.

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The Effects of KBT-3022, a New Anti-platelet Agent, on Hemorheological Properties in Guinea Pigs

Thrombosis and Haemostasis ◽

10.1055/s-0038-1653735 ◽

1995 ◽

Vol 73 (01) ◽

pp. 118-121 ◽

Cited By ~ 6

Author(s):

Noriko Yamamoto ◽

Koichi Yokota ◽

Akira Yamashita ◽

Minoru Oda

Keyword(s):

Shear Stress ◽

Blood Viscosity ◽

Guinea Pigs ◽

Direct Action ◽

Plasma Viscosity ◽

Fibrinogen Concentration ◽

Anti Platelet Agent ◽

Blood Filterability ◽

2,3 Dpg ◽

Rbc Deformability

SummaryUsing guinea pigs, a study was conducted on the effects of KBT-3022, a new anti-platelet agent, on hemorheological properties in various tests including blood filterability, blood viscosity, shear stress-induced red blood cell (RBC) deformability and contents of ATP and 2,3-diphosphoglycerate (2,3-DPG). Oral administration of KBT-3022 at 1 and 10 mg/kg significantly increased blood filterability, and significantly reduced blood viscosity at 10 mg/kg without changing the hematocrit, plasma fibrinogen concentration or plasma viscosity. KBT-3022 (10 mg/kg, p.o.) improved RBC deformability in response to shear stress, which was evoked by passing the blood through a thin tube. This dose of KBT-3022 also increased the contents of ATP and 2,3-DPG in RBC. These findings indicate that KBT-3022 may reduce blood viscosity as a sequel to improvement of RBC deformability through direct action on RBC. The increase in the intracellular levels of ATP and 2,3-DPG was considered to be involved in this improvement of hemorheological properties. These hemorheological effects of KBT-3022 appear to be promising for the treatment of patients with ischemic vascular disease.

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Core Statutes On Conflict Of Laws 2018–19

10.1057/978-1-352-00342-0 ◽

2018 ◽

Author(s):

Emmanuel Maganaris

Keyword(s):

Conflict Of Laws

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Comparative analysis of changes of bioelectrical activity of the brain during the neutral touch and during the performance of the myofascial release technique

Russian Osteopathic Journal ◽

10.32885/2220-0975-2018-1-2-46-55 ◽

2018 ◽

pp. 46-55

Author(s):

A. F. Belyaev ◽

G. E. Piskunova

Keyword(s):

Soft Tissue ◽

Brain Activity ◽

Direct Action ◽

Brain Regions ◽

Therapeutic Touch ◽

Bioelectrical Activity ◽

Therapeutic Action ◽

Osteopathic Treatment ◽

The Difference ◽

Multiparameter Analysis

Introduction. One of the main tools of an osteopath are soft tissue techniques, which have a number of particular qualities such as minimization of force and duration of indirect techniques with an emphasis on muscle and ligamentous structures; combination of gestures, tendency to maximal relaxation and exclusion of direct action on pathological symptoms such as tension, overtone and pain. Minimization of the force applied during the performance of soft tissue techniques often invites a question whether there are differences between the usual touch and the therapeutic touch of an osteopath.Goal of research - to reveal the changes in the bioelectrical activity of the cerebral cortex arising in the process of osteopathic treatment in order to prove its speciﬁ city in comparison with nonspeciﬁ c tactile stimulation (neutral touch).Materials and methods. 75 people were examined with the use of multiparameter analysis of multichannel EEG in different times. 25 patients were clinically healthy adults, whereas 50 patients had signs of somatic dysfunctions.Results. Computer encephalography permits to perceive the difference between the neutral touch and the therapeutic action. An identiﬁ cation reaction is a response to the neutral touch (changes in brain bioelectrical activity with an increase in statistically signiﬁ cant connections in the temporal lobes), whereas the therapeutic action provokes the state of purposeful brain activity during still point (intensiﬁ cation of frontooccipital interactions).Conclusions. Osteopathic action causes additional tension in the processing of incoming information, which requires participation of different brain regions, including interhemispheric mechanisms associated with analysis, maintenance of attention and regulation of targeted activities.

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