The Bicycle and the Common Carrier

1898 ◽  
Vol 12 (2) ◽  
pp. 119
Author(s):  
Lee Max Friedman
Keyword(s):  
1980 ◽  
pp. 157-174
Author(s):  
Robert Techo
Keyword(s):  

1948 ◽  
Vol 24 (3) ◽  
pp. 253
Author(s):  
William A. Spurr
Keyword(s):  

1987 ◽  
Vol 245 (3) ◽  
pp. 929-931 ◽  
Author(s):  
S J Bird ◽  
S Forster ◽  
J B Lloyd

A conflict exists in the literature concerning the mode of translocation of D-glucose and D-ribose across the lysosome membrane. The more rapid net uptake of ribose, when measured by the osmotic-protection technique, has been attributed either to its smaller size and lower hydrogen-bonding capacity, or to a lower affinity for a transport system shared by both sugars. The latency of acid beta-hexosaminidase in isolated rat liver lysosomes was measured after preincubation for periods up to 1 h in various solutions containing glucose and/or ribose, and in some cases sucrose. After confirmation of the superior osmotic protection afforded by glucose (than by ribose), it was shown that a solution 0.125 M in both glucose and ribose provided protection intermediate between that given by 0.25 M-glucose and that given by 0.25 M-ribose. This result is inconsistent with the common-carrier hypothesis.


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