Approximate Maximum Likelihood Estimates from Grouped Data

Technometrics ◽  
1967 ◽  
Vol 9 (4) ◽  
pp. 599 ◽  
Author(s):  
G. M. Tallis
Keyword(s):  
Maximum Likelihood ◽  
Maximum Likelihood Estimates ◽  
Grouped Data ◽  
Approximate Maximum Likelihood

Retention or Attrition Models

1989 ◽  
Vol 14 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Irwin Guttman ◽  
Ingram Olkin
Keyword(s):  
Maximum Likelihood ◽  
Bayesian Analysis ◽  
Maximum Likelihood Estimates ◽  
Attrition Rates ◽  
Approximate Maximum Likelihood ◽  
Alternative Models

A model for retention and its counterpart, attrition, is presented. In a prototype example, students enter a program in each of k terms; some of the students complete the program, and the remainder leave. A key feature in the models proposed is that there is a dampening effect from term to term because the probability of leaving the program diminishes as the terms progress. The focus of this paper is the study of alternative models for the dampening in attrition rates. A number of alternative dampening effects are proposed that provide for different rates of attrition. Approximate maximum likelihood estimates for the underlying parameters in each model and a Bayesian analysis are provided.

Box-Cox Transformations

2017 ◽  
Author(s):  
Russell Cheng
Keyword(s):  
Maximum Likelihood ◽  
Normal Form ◽  
Maximum Likelihood Estimate ◽  
Likelihood Estimate ◽  
Grouped Data ◽  
Numerical Example ◽  
Alternative Method ◽  
Modified Likelihood

This chapter examines the well-known Box-Cox method, which transforms a sample of non-normal observations into approximately normal form. Two non-standard aspects are highlighted. First, the likelihood of the transformed sample has an unbounded maximum, so that the maximum likelihood estimate is not consistent. The usually suggested remedy is to assume grouped data so that the sample becomes multinomial. An alternative method is described that uses a modified likelihood similar to the spacings function. This eliminates the infinite likelihood problem. The second problem is that the power transform used in the Box-Cox method is left-bounded so that the transformed observations cannot be exactly normal. This biases estimates of observational probabilities in an uncertain way. Moreover, the distributions fitted to the observations are not necessarily unimodal. A simple remedy is to assume the transformed observations have a left-bounded distribution, like the exponential; this is discussed in detail, and a numerical example given.

scholarly journals Directional Selection and the Site-Frequency Spectrum

Genetics ◽  
2001 ◽  
Vol 159 (4) ◽  
pp. 1779-1788 ◽  
Author(s):  
Carlos D Bustamante ◽  
John Wakeley ◽  
Stanley Sawyer ◽  
Daniel L Hartl
Keyword(s):  
Maximum Likelihood ◽  
High Power ◽  
Negative Selection ◽  
Likelihood Estimation ◽  
Directional Selection ◽  
Likelihood Ratio Tests ◽  
Maximum Likelihood Estimates ◽  
Likelihood Methods ◽  
Ancestral States ◽  
Asymptotic Variances

Abstract In this article we explore statistical properties of the maximum-likelihood estimates (MLEs) of the selection and mutation parameters in a Poisson random field population genetics model of directional selection at DNA sites. We derive the asymptotic variances and covariance of the MLEs and explore the power of the likelihood ratio tests (LRT) of neutrality for varying levels of mutation and selection as well as the robustness of the LRT to deviations from the assumption of free recombination among sites. We also discuss the coverage of confidence intervals on the basis of two standard-likelihood methods. We find that the LRT has high power to detect deviations from neutrality and that the maximum-likelihood estimation performs very well when the ancestral states of all mutations in the sample are known. When the ancestral states are not known, the test has high power to detect deviations from neutrality for negative selection but not for positive selection. We also find that the LRT is not robust to deviations from the assumption of independence among sites.

scholarly journals An Integrated Framework for the Inference of Viral Population History From Reconstructed Genealogies

Genetics ◽  
2000 ◽  
Vol 155 (3) ◽  
pp. 1429-1437
Author(s):  
Oliver G Pybus ◽  
Andrew Rambaut ◽  
Paul H Harvey
Keyword(s):  
Maximum Likelihood ◽  
Sequence Data ◽  
Demographic History ◽  
Population History ◽  
Maximum Likelihood Estimates ◽  
Viral Population ◽  
True Parameter ◽  
Subtype B ◽  
Exponential Growth Model ◽  
Parameter Values

Abstract We describe a unified set of methods for the inference of demographic history using genealogies reconstructed from gene sequence data. We introduce the skyline plot, a graphical, nonparametric estimate of demographic history. We discuss both maximum-likelihood parameter estimation and demographic hypothesis testing. Simulations are carried out to investigate the statistical properties of maximum-likelihood estimates of demographic parameters. The simulations reveal that (i) the performance of exponential growth model estimates is determined by a simple function of the true parameter values and (ii) under some conditions, estimates from reconstructed trees perform as well as estimates from perfect trees. We apply our methods to HIV-1 sequence data and find strong evidence that subtypes A and B have different demographic histories. We also provide the first (albeit tentative) genetic evidence for a recent decrease in the growth rate of subtype B.

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