scholarly journals An Essay on the Principles of Circumstantial Evidence

1906 ◽  
Vol 11 (9) ◽  
pp. 784
Author(s):  
Alfred Wills
Keyword(s):  
Circumstantial Evidence

Immunocytochemical Identification of Tubulin Containing Paracrystals in Allogromia Reticulopods

1985 ◽  
Vol 43 ◽  
pp. 486-487
Author(s):  
Gerald Rupp
Keyword(s):  
Light Microscopy ◽  
Ultrastructural Analysis ◽  
Circumstantial Evidence ◽  
Intermediate Form

The marine protozoan Allogromia sp, strain NF Lee extends an elaborate reticulopodial network (RN) which contains an elongate microtubule-(MT)-based cytoskeleton. The MTs are located primarily within cytoplasmic fibrils which are visible by light microscopy (LM) in highly flattened or “two dimensionalized” reticulopodia. It was shown previously that allogromiid RNs withdraw in response to hypertonic Mg2+-seawater. An ultrastructural analysis of this phenomenon indicated that large patches of paracrystalline (PC) material, composed of helical filament aggregates, form concomitant with a decrease in MT number. Similar large patches of PC aggregates are also found in juvenile Allogromia before they extend a RN, which disappear during RN formation. Finally, PC aggregates are occasionally seen near microtubules in normal untreated RNs. Thus there is circumstantial evidence to propose that PC aggregates in Allogromia represent an intermediate form of tubulin; however, more definitive biochemical or immunocytochemical data is not available.

A Hitherto Undescribed Naturally Occurring Plasma Antagonist of Activated Factor X Inhibitor (Antithrombin III)

1979 ◽  
Author(s):  
E. T. Yin ◽  
W. J. Salsgiver ◽  
O. Tangen
Keyword(s):  
Equilibrium State ◽  
Human Plasma ◽  
Antithrombin Iii ◽  
Circumstantial Evidence ◽  
Incubation Mixture ◽  
Factor X ◽  
Normal Human Plasma ◽  
Plasma Component ◽  
Naturally Occurring ◽  
Normal Human

Circumstantial evidence suggested that normal human plasma contained a substance regulating the neutralization of F.Xa by F.Xa inhibitor(XaI), (Yin et.al.,Adv.Exper. Med. & Biol., 52 : 239, 1975, Plenum Press, N.Y.).This plasma component has now been isolated and partially purified in our laboratory, and tentatively designated as “Anti-XaI”.In experiments employing purified components, when Anti-XaI was incubated at 37°C with F.Xa, Xal and heparin for two minutes at pH7.5, the amount of F.Xa inhibited was inversely proportional to the Anti-XaI concentration. But, when the F.Xa was replaced by thrombin in the incubation mixture, the neutralization of thrombin clotting activity was undisturbed.Anti-XaI was found to be neither PF3 nor PF4.These and other data strongly suggest that the “Antithrombin III pathway” is more complex than currently believed to be. In circulating blood an equilibrium state must exist between Anti-XaI and XaI.Under certain conditions when the Anti-XaI activity is predominant the rate of F.Xa neutralization bv XaI then becomes slower than the activation of prothrombin to thrombin by F.Xa.

Forensik und Fiktion. Zur Geschichte von Indizien zwischen Wahr-Werden und Wahrscheinlich-Sein

2019 ◽  
Vol 48 (1) ◽  
pp. 29-55
Author(s):  
Antonia Eder
Keyword(s):  
18Th Century ◽  
Circumstantial Evidence ◽  
Forensic Evidence

Abstract The ambivalent status of circumstantial evidence has been intensively discussed since the 18th century, in both fiction and forensics. (Forensic) evidence is both hermeneutic and material – a phenomenon of ambiguity: the conclusions to be drawn from clues are generated by an amalgam of enlightened promises of objectivity and the opaque materiality of the surface. According to the forensic and juridical hope associated with circumstantial evidence, neutral things do not lie, but show (evidentia) as pars pro toto the actual facts in nuce. Yet every fact, every thing remains tied back to a closing instance, to the investigative and hermeneutic conclusions of thought: this opens the operational field of literature. Poetic dynamics enable literature to simultaneously cope with indexed ambiguity and indeterminacy, both by producing them, and by reflecting on them by means of detective-investigative self-observation.

An investigation of the thermal death kinetics ofMycobacterium paratuberculosisduring pasteurisation

2000 ◽  
Vol 25 ◽  
pp. 71-76
Author(s):  
M.T. Rowe ◽  
I.R. Grant ◽  
H.J. Ball ◽  
C. Pope
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Heat Resistance ◽  
Raw Milk ◽  
Circumstantial Evidence ◽  
Infected Cattle ◽  
Thermal Death ◽  
Death Kinetics ◽  
Viability Stain ◽  
Thermal Death Kinetics

AbstractMycobacterium paratuberculosis is the known cause of Johne's disease in cattle and has been implicated as a cause of Crohn's disease in humans. Concern has been expressed that the organism, which is excreted in milk and faeces of infected cattle, may be transmitted via pasteurised milk. This is largely from work that has shown an unacceptable risk of survival of the organism when it is present in raw milk at numbers exceeding 102cfu/ml. Three possible reasons for this apparent heat resistance were investigated viz. use of a milk heating menstruum, presence of a heat resistant sub–population, and the tendency of the organism to form clumps. Heat resistance studies using a combined acid–fast/viability stain, and a comparison of the relative heat sensitivities of clumped and de-clumped M. paratuberculosis cells provided circumstantial evidence that it is the organism's tendency to form clumps which confers the apparent heat resistance. This work casts doubt on the efficacy of current commercial pasteurisation heat treatments (72°C/15s) for the inactivation of M. paratuberculosis. This would be of concern if a link between M. paratuberculosis and Crohn's disease is eventually established.

Seeing the Empress Again On Doubling in L'incoronazione di Poppea

2012 ◽  
Vol 24 (3) ◽  
pp. 249-291
Author(s):  
Magnus Tessing Schneider
Keyword(s):  
Seventeenth Century ◽  
Sixteenth Century ◽  
Circumstantial Evidence

AbstractThis article presents a reading of Gian Francesco Busenello's and Claudio Monteverdi's opera L'incoronazione di Poppea in light of seventeenth-century theatrical practices. Reconstructing the doubling plan from the opera's premiere in 1643 on the basis of contemporary doubling practices and the correspondence of the Ferrarese music patron Marquess Cornelio Bentivoglio, the author argues, adducing circumstantial evidence, that Ottavia and Drusilla were conceived as a double role for the operatic quick-change artist Anna Renzi. While Renzi is known to have created Ottavia, this part is half the size of all other roles written for her, which invariably involve dramatic, emotional and musical variety to a much greater extent than does Monteverdi's tragic Empress. Renzi was admired for her command of both tragedy and comedy, and the essay develops the hypothesis of the double role as an intertextual interpenetration of the title heroines from the pseudo-Senecan tragedy Octavia and Girolamo Bargagli's sixteenth-century comedy La pellegrina.

scholarly journals Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

Diabetologia ◽  
2010 ◽  
Vol 53 (6) ◽  
pp. 1046-1056 ◽  
Author(s):  
S. Zraika ◽  
R. L. Hull ◽  
C. B. Verchere ◽  
A. Clark ◽  
K. J. Potter ◽  
...  
Keyword(s):  
Cell Death ◽  
Beta Cell ◽  
Circumstantial Evidence ◽  
Beta Cell Death ◽  
Islet Beta Cell

Steroids and steroidases. IX. Activation parameters and the mechanism of base- and enzyme-catalyzed isomerizations of androst-5-ene-3,17-dione. The nature of the active center of the Δ5 → Δ4-3-ketosteroid isomerase of Pseudomonas testosteroni

1969 ◽  
Vol 47 (23) ◽  
pp. 4459-4466 ◽  
Author(s):  
J. Bryan Jones ◽  
Donald C. Wigfield
Keyword(s):  
Amino Acids ◽  
Active Center ◽  
Activation Parameters ◽  
Circumstantial Evidence ◽  
Kcal Mole ◽  
Acid Base ◽  
Ketosteroid Isomerase ◽  
Enzyme Action ◽  
Enthalpy Of Activation

Determination of the activation parameters for the acid-, base-, and enzyme-catalyzed isomerizations of androst-5-ene-3,17-dione has revealed that the facility of the enzymic process is mainly due to an extremely low enthalpy of activation of 5.0 kcal mole−1. Further circumstantial evidence regarding the nature of the reacting groups at the active center has also been obtained, and a mechanism of enzyme action is proposed employing tyrosine and histidine as the principal amino acids responsible for catalyzing the isomerization.

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