scholarly journals Large neck metastasis with unknown primary tumor - a case report

2021 ◽  
pp. 37-37
Author(s):  
Milovan Dimitrijevic ◽  
Bojana Bukurov ◽  
Ana Jotic
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Primary Tumor ◽  
Head And Neck Carcinoma ◽  
Unknown Primary ◽  
Unknown Primary Tumor ◽  
Neck Carcinoma ◽  
Regional Disease

Introduction. Metastatic head and neck carcinoma from an unknown primary tumor is defined as a metastatic disease in the neck?s lymph nodes without evidence of a primary tumor after appropriate investigation. Multiple national guidelines recommend that essential steps in diagnostic protocols involve a detailed clinical exam with radiological imaging, fine-needle aspiration (FNA) biopsy of the cervical tumor, panendoscopy with palatine and lingual tonsillectomy, immunohistochemical staining, and human papillomavirus (HPV) detection. Treatment of head and neck carcinomas of unknown primary (CUPs) origin involves surgery (neck dissection) with radiotherapy, while some authors recommend chemo-radiotherapy in cases of the advanced regional disease. Case report. A 44-year old male was referred to the tertiary medical center because of a large ulcero-infiltrative cervical mass on the right side. Examination of the head and neck and flexible nasopharyngolaryngeal endoscopy was conducted, followed by computed tomography (CT) of the head, neck, and thorax with intravenous contrast. The primary localization of the tumor was not confirmed by these diagnostic methods. Open biopsy of the neck mass confirmed histopathology diagnosis of metastatic squamous cell carcinoma. Results of panendoscopy with biopsies and bilateral tonsillectomy were negative for malignancy. Treatment included extended radical neck dissection with reconstruction and postoperative ipsilateral radiotherapy. Five years after the first surgery, the patient presented with an extensive pharyngolaryngeal tumor. Biopsy with histopathology examination confirmed the diagnosis of squamous cell carcinoma. Conclusion. A structured step-by-step diagnostic approach in identifying the primary site of the metastatic head and neck carcinoma is mandatory. Substantial advances in diagnostics and operative techniques have increased the likelihood of primary tumor identification, as well as detection of regional and systemic spread of the disease. Purpose of adherence to guidelines results in higher overall-survival and longer regional disease-free survival in these patients.

Immunological microenvironment in the clinical outcome of some solid tumors

2016 ◽  
Vol 21 (1-2) ◽  
pp. 55-59
Author(s):  
G. M Manikhas ◽  
Svetlana I. Kutukova ◽  
N. P Beliak ◽  
G. A Raskin ◽  
A. I Yaremenko ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Outcome ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Solid Tumors ◽  
Squamous Cell ◽  
Head And Neck Carcinoma ◽  
Regional Lymph Nodes ◽  
Neck Carcinoma ◽  
Colorectal Adenocarcinomas

In our clinical research we studied levels of neutrophils, eosinophils and CD8 T-lymphocytes in stroma and microenvironment of the gastric and colorectal adenocarcinomas, head and neck squamous cell carcinomas (33 patients: 15 with adenocarcinoma and 18 - with head and neck carcinoma). In gastric or colorectal adenocarcinoma expression of neutrophils directly correlates with regional lymph nodes involving, expression of CD8 has inversely correlation with differentiation of the tumor. In head and neck squamous cell carcinoma neutrophils expression inversely correlates with keratinization, CD8 expression has inversely correlation with the size of primary tumor and stage, and has direct correlation with keratinization. This study allows to draw a conclusion about heterogeneity of solid tumors depending on immunology of microenvironment, moreover squamous cell carcinoma of head and neck is more “immunocompetent” structure. Correlation analysis revealed prognostic and predictive value of immunological microenvironment, because showed impact of expression of CD8, neutrophils and eosinophils on clinical outcome of gastric and colorectal adenocarcinomas and squamous cell carcinoma of head and neck.

Metastatic Squamous Cell Carcinoma of an Unknown Primary Tumor Localized to the Neck

1992 ◽  
Vol 4 (1) ◽  
pp. 41-45 ◽  
Author(s):  
B. Jeremic ◽  
Lj. Djuric ◽  
S. Jevremovic ◽  
B. Stanisavljevic ◽  
Lj. Milojevic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Unknown Primary ◽  
Unknown Primary Tumor ◽  
Metastatic Squamous Cell Carcinoma

Intracardiac metastasis from head and neck squamous cell carcinoma

2020 ◽  
Vol 13 (6) ◽  
pp. e234691
Author(s):  
Suha Abu Khalaf ◽  
Talha Riaz ◽  
Abdallah Mansour ◽  
Donald Doll
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Case Reports ◽  
Head And Neck Carcinoma ◽  
Limb Ischemia ◽  
Cardiac Metastasis ◽  
Review Of The Literature ◽  
Neck Carcinoma

Cardiac metastasis from head and neck cancer is an extremely rare and devastating condition with an abysmal prognosis. Most of our knowledge about this condition is from case reports and series. We present a case of squamous cell carcinoma of the tonsils that was complicated by embolic stroke and critical limb ischemia that were found to be secondary to intracardiac metastasis. We believe that this condition is under-reported; hence, we conducted a thorough review of the literature to highlight the characteristics and previous therapeutic experiences with various presentations of cardiac metastasis from head and neck carcinoma. Clinicians are encouraged to report their experience with evaluating and managing this type of metastasis.

scholarly journals 123I-Interleukin-2 uptake in squamous cell carcinoma of the head and neck carcinoma

2007 ◽  
Vol 35 (2) ◽  
pp. 281-286 ◽  
Author(s):  
David Loose ◽  
Alberto Signore ◽  
Ludovicus Staelens ◽  
Katia Vanden Bulcke ◽  
Hubert Vermeersch ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Interleukin 2 ◽  
Head And Neck Carcinoma ◽  
Neck Carcinoma

Value of Radionucleotide Scanning in the Staging of Head and Neck Carcinoma

1979 ◽  
Vol 88 (6) ◽  
pp. 832-836 ◽  
Author(s):  
Judith A. Wolfe ◽  
Lee D. Rowe ◽  
Louis D. Lowry
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Head And Neck Carcinoma ◽  
Distant Metastases ◽  
Primary Squamous Cell Carcinoma ◽  
True Value ◽  
Neck Carcinoma ◽  
Initial Staging

The presence or absence of distant metastases in squamous cell carcinoma of the head and neck is critical in making rational therapeutic decisions. Radionucleotide bone and liver scans are frequently utilized in the initial evaluation of these patients for possible distant metastases. The true value of routine bone and liver scans in the initial staging of primary squamous cell carcinoma of the head and neck is unknown. One hundred eighteen patients with primary squamous cell carcinoma of the head and neck, evaluated during a five-year period, were retrospectively reviewed. Eight percent were stage I, 18% stage II, 21% stage III, 53% stage IV. Because metastatic carcinoma of the head and neck is primarily regional or pulmonary, the low prevalence of liver and bone metastases limits the usefulness of these radionucleotide scans. We conclude that routine bone and liver scanning is not a valuable diagnostic technique in the initial staging of head and neck carcinoma when clinical or biochemical evidence of distant metastases is not present.

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