scholarly journals Doppler middle cerebral artery peak systolic velocity measurement as diagnostic tool for fetal anemia after in-utero transfusions in red blood cell alloimmunisation

2020 ◽  
Vol 77 (1) ◽  
pp. 8-13
Author(s):  
Mirjana Marjanovic-Cvjeticanin ◽  
Snezana Plesinac ◽  
Jelena Dotlic ◽  
Darko Plecas ◽  
Dusica Kocijancic-Belovic ◽  
...  
Keyword(s):  
Blood Cell ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Red Blood Cell ◽  
Diagnostic Tool ◽  
Peak Systolic Velocity ◽  
In Utero ◽  
Fetal Anemia ◽  
Transfusion Therapy ◽  
Before And After

Background/Aim. Doppler sonography of fetal middle cerebral artery peak systolic velocity (MCA-PSV) can be used to predict fetal anemia and the need for in utero intravascular transfusion (IUIT) in red blood cell (RBC) alloimmunisation pregnancies. The aim of this study was to evaluate whether measurement of MCA-PSV in fetuses that had undergone one to three transfusions is a good diagnostic tool for fetal anemia. Methods. Study included 36 pregnancies treated due to RBC alloimmunisation in our tertiary referral center during the 5-year period (2012?2017). We measured MCA-PSV and hematocrit (Hct) in all patients. In seven pregnancies there was a need to perform sequential IUITs for correction of fetal anemia. In these patients we compared MCA-PSV and Hct values before and after every transfusion. Results. Hct and MCA-PSV correlated negatively before transfusion therapy (p = 0.035) and after the second transfusion (p = 0.046). Contrary, after the first (p = 0.954), before the second (p = 0.738), as well as before (p = 0.092) and after (p = 0,741) the third transfusions there were no significant correlations between Hct and MCAPSV values. Hct values before and after transfusions were positively associated (p = 0.001), but MCA-PSV were not (p = 0.296). According to performed receiver operating characteristic (ROC) analysis the cut-off point of MCA-PSV for investigated patients was 1.22 multiples of its median (MoM). Conclusion. There is a reduction in MCA-PSV accuracy for assessing fetal anemia in previously transfused fetuses. Larger studies are needed to explain the reasons for these findings and potentially set new referral values of MCA-PSV for better diagnostics of fetal anemia.

scholarly journals Doppler Flow Velocity Indices (RI, PI, S/D & PSV) of Fetal Middle Cerebral Artery in Normal Pregnancies: Correlation with Gestational Age of 20 to 40 Weeks

2012 ◽  
Vol 2 (2) ◽  
pp. 77-80
Author(s):  
Md Abu Taher ◽  
Nuzhat Tasmin ◽  
AS Mohiuddin ◽  
Md Mohit Ul Alam ◽  
Md Mofazzal Sharif ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Flow Velocity ◽  
Cerebral Artery ◽  
Gestational Age ◽  
Resistance Index ◽  
Peak Systolic Velocity ◽  
Doppler Flow ◽  
Significant Difference ◽  
Before And After ◽  
Doppler Indices

This observational type of descriptive study was carried out in the Department of Radiology and Imaging, BIRDEM selecting 70 Bangladeshi pregnant babies with the aim to find out the normogram of foetal middle cerebral artery Doppler flow velocity indices and correlation between Doppler flow velocity indices [Resistance Index (RI), Pulsatility Index (PI), Systolic/Diastolic ratio (S/D) & Peak Systolic Velocity (PSV)] of foetal middle cerebral artery and gestational age in normal pregnancies of 20 to 40 weeks. It was observed that RI, PI and S/D were decreased with the advance of gestational age but PSV was increases with the advance of gestational age. Statistical analyses showed there were significant difference between mean PSV, RI and PI before and after 25 weeks of gestation. No significant difference was found between mean S/D before and after 25 weeks of gestation. It was observed from Correlation analysis between Doppler indices with independent gestational age that all the Doppler indices of foetal middle cerebra artery was positively correlated with the whole gestation period. The statistical analysis showed only PSV and RI were significantly correlated with the gestational age. Simple regression analysis between dependent Doppler index with independent gestational age before and after 25 weeks revealed that all the Doppler indices had positive relationship with the corresponding gestational age but relationship between PSV and PI (before 25 weeks) with their corresponding gestational ages were only statistically significant.DOI: http://dx.doi.org/10.3329/birdem.v2i2.12306 Birdem Med J 2012; 2(2) 77-80

scholarly journals OP24.07: Prediction of moderate fetal anemia risk by longitudinal assessments of middle cerebral artery peak systolic velocity

2010 ◽  
Vol 36 (S1) ◽  
pp. 123-123
Author(s):  
M. Pětroš ◽  
M. Liška ◽  
D. Matura ◽  
P. Kordoš ◽  
O. Šimetka ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Peak Systolic Velocity ◽  
Fetal Anemia

Suspected hemorrhagic ovarian cyst causing fetal anemia measured by the peak systolic velocity in the middle cerebral artery

2013 ◽  
Vol 171 (1) ◽  
pp. 187-188 ◽  
Author(s):  
Sandy A. Hanssens ◽  
Capucine D. Coulon ◽  
Elodie M. Clouqueur ◽  
Philippe L. Bourgeot ◽  
Pascal G. Vaast ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Ovarian Cyst ◽  
Peak Systolic Velocity ◽  
Fetal Anemia

scholarly journals Prediction of Fetal Anemia by Middle Cerebral Artery Peak Systolic Velocity in Pregnancies Complicated by Rhesus Isoimmunization

2003 ◽  
Vol 23 (7) ◽  
pp. 536-540 ◽  
Author(s):  
M M Alshimmiri ◽  
M S Hamoud ◽  
E A Al-Saleh ◽  
K Y Mujaibel ◽  
J A Al-Harmi ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Peak Systolic Velocity ◽  
Fetal Anemia

Comparison of the Performances of Middle Cerebral Artery Peak Systolic Velocity and Cardiothoracic Diameter Ratio in Predicting Fetal Anemia: Using Fetal Hemoglobin Bart’s Disease as a Study Model

2021 ◽  
pp. 1-8
Author(s):  
Wisit Chankhunaphas ◽  
Theera Tongsong ◽  
Fuanglada Tongprasert ◽  
Kasemsri Srisupundit ◽  
Suchaya Luewan ◽  
...  
Keyword(s):  
At Risk ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Gestational Age ◽  
Peak Systolic Velocity ◽  
Fetal Hemoglobin ◽  
Diameter Ratio ◽  
Fetal Anemia ◽  
Receiver Operating Characteristic Curves ◽  
Hb Bart's

<b><i>Objective:</i></b> The aim of the study was to compare the performances of cardiothoracic diameter ratio (CTR) and middle cerebral artery peak systolic velocity (MCA-PSV) in predicting fetal hemoglobin (Hb) Bart’s disease and identify the best CTR cut-off for each gestational period. <b><i>Methods:</i></b> Pregnancies at risk of fetal Hb Bart’s disease (gestational ages of 12–36 weeks) were prospectively recruited to undergo ultrasound examination. The measurements of CTR and MCA-PSV were performed and recorded before invasive diagnosis. <b><i>Results:</i></b> During the study period (2005–2019), a total of 1,717 pregnancies at risk of fetal Hb Bart’s disease met the inclusion criteria and were available for analysis, including 329 (19.2%) fetuses with Hb Bart’s disease. The mean gestational age at the time of diagnosis was 19.30 ± 5.6 weeks, ranging from 12 to 36 weeks. The overall performance of CTR <i>Z</i>-scores is superior to that of MCA-PSV multiple of median (MoM) values; area under curve of 0.866 versus 0.711, <i>p</i> value &#x3c;0.001. The diagnostic indices of CTR and MCA-PSV are increased with gestational age. Based on receiver operating characteristic curves of CTR <i>Z</i>-scores, the best cut-off points of CTR at 12–14, 15–17, 18–20, 21–23, and ≥24 weeks are 0.48, 0.49, 0.50, 0.51, and 0.54, respectively. The best cut-off of MCA-PSV is 1.3 MoM, giving the best performance at 21–23 weeks with a sensitivity of 91.8% and specificity of 85.5%. <b><i>Conclusion:</i></b> The performance of CTR is much better than MCA-PSV in predicting fetal anemia caused by Hb Bart’s disease. Nevertheless, whether this can be reproduced in anemia due to other causes, like isoimmunization, is yet to be explored.

scholarly journals Elevated middle cerebral artery peak systolic velocity without fetal anemia in a case of homozygous α–thalassemia-1

2008 ◽  
Vol 28 (1) ◽  
pp. 72-74 ◽  
Author(s):  
Karla Maguire ◽  
Anthony Johnson ◽  
Ching-Nan Ou ◽  
Regina L. Lantin ◽  
Kenneth J. Moise
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Peak Systolic Velocity ◽  
Fetal Anemia

scholarly journals Fetal middle cerebral artery peak systolic velocity as a predictor of fetal anemia in unselected women giving birth at or near term

2019 ◽  
Vol 58 (2) ◽  
pp. 212-217 ◽  
Author(s):  
Kosuke Kawabata ◽  
Mamoru Morikawa ◽  
Satoshi Ishikawa ◽  
Kinuko Nakagawa ◽  
Kentaro Chiba ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Peak Systolic Velocity ◽  
Fetal Anemia ◽  
Near Term
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