scholarly journals A fatal case of fulminant myocarditis caused by influenza A virus

2019 ◽  
Vol 76 (12) ◽  
pp. 1290-1296
Author(s):  
Mila Kovacevic ◽  
Ilija Srdanovic ◽  
Milana Jarakovic ◽  
Dragana Bogdanovic ◽  
Milenko Cankovic
Keyword(s):  
Intensive Care ◽  
Cardiogenic Shock ◽  
Influenza A Virus ◽  
Influenza A ◽  
Fatal Case ◽  
Fulminant Myocarditis ◽  
Circulatory Support ◽  
Nasopharyngeal Swab ◽  
Life Threatening ◽  
Artery Disease

Introduction. Myocarditis is defined as an inflammation of a heart muscle, which can be caused by a number of agents, among which viruses are the most common. Fulminant myocarditis is a rapidly progressive, life-threatening myocarditis, followed by the development of cardiogenic shock. Among viruses, there are a number of common ones, but according to our knowledge, there are only a few cases of fulminant myocarditis caused by influenza A virus described in the literature. Case report. We presented a 44-year-old man who was admitted to the Cardiology Intensive Care Unit because of the clinical as well as electrocardiographic signs pointing to the STsegment elevated myocardial infarction with peracute development of heart failure and cardiogenic shock and subsequently lethal outcome, despite applied circulatory support. The urgent coronarography showed no signs of coronary artery disease, while the autopsy revealed myocarditis and the realtime polymerase chain reaction of nasopharyngeal swab revealed influenza A(H3) virus. Conclusion. Fulminant myocarditis is a life-threatening cardiac disease which should be treated in Intensive Care Units with both medicament and mechanical circulatory support and antiviral therapy and which, despite the applied therapy, has a high mortality rate. Influenza A virus is a rare cause of fulminant myocarditis which should be taken into consideration.

scholarly journals Life-threatening cardiogenic shock in a pediatric patient with SARS-CoV-2-associated myocarditis treated with remdesivir: a case description and report of similar cases from the Literature

2020 ◽  
Author(s):  
Silvia Molinari ◽  
Lucia M.D. Cola ◽  
Maria L. Melzi ◽  
Alessandro Cattoni ◽  
Roberto Panceri ◽  
...  
Keyword(s):  
Cardiogenic Shock ◽  
Antiviral Agent ◽  
Respiratory Illness ◽  
Positive Outcome ◽  
Left Ventricular ◽  
Fulminant Myocarditis ◽  
Nasopharyngeal Swab ◽  
Gradual Improvement ◽  
Negative Results ◽  
Life Threatening

Abstract BackgroundChildren are relatively spared from Coronavirus disease 2019 (COVID-19), but some severe cases have been reported. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children may affect the cardiovascular system. We hereby report about a case of myocarditis evolving to cardiogenic shock in a SARS-CoV-2 positive child.Case presentationAn otherwise healthy 12-year-old patient was admitted with fever, vomiting, diarrhoea and drowsiness, without any respiratory symptoms. He was diagnosed with COVID-19 on nasopharyngeal swab. He developed hypotension and cardiogenic shock. Bedside echocardiography revealed left ventricular impairment with an ejection fraction (LVEF) below 25%. Plasmatic markers of myocardial injury were remarkably raised, as well as inflammatory biomarkers, including procalcitonin (highest recorded value: 66 ng/mL) and interleukin-6 (8209 pg/mL). The child was transferred to Intensive Care Unit and he was treated with catecholamine support, mechanical ventilation and empiric anti-infectious therapy, including broad spectrum antibiotics and the antiviral agent remdesivir. All additional microbiological investigations yielded negative results. We observed a gradual improvement of LVEF within 5 days. A cardiac magnetic resonance confirmed the suspicion of myocarditis. After 21 days of hospitalisation, the child was discharged without sequelae.ConclusionsOur hypothesis is that the child suffered from SARS-CoV-2-induced fulminant myocarditis, probably in the setting of cytokine release syndrome (CRS). The peculiarity of this SARS-CoV-2 infection is the presence of cardiac failure in a previously healthy child without a respiratory illness. The positive outcome is in line with published Literature about the overall better prognosis of COVID-19 children compared to adults. Remdesivir, an investigational antiviral therapy, may have played a role on the clinical improvement of the child.

scholarly journals Successful management of Influenza A associated fulminant myocarditis: mobile circulatory support in intensive care unit: a case report

Cases Journal ◽  
2008 ◽  
Vol 1 (1) ◽  
Author(s):  
Ambroise Montcriol ◽  
Sandrine Wiramus ◽  
Alberto Ribeiri ◽  
Nathalie Attard ◽  
Lyacine Nait-Saidi ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Case Report ◽  
Influenza A ◽  
Fulminant Myocarditis ◽  
Circulatory Support ◽  
Successful Management

scholarly journals Errata

2021 ◽  
Vol 78 (2) ◽  
pp. 281-281
Author(s):  
E Editorial
Keyword(s):  
Mental Health ◽  
Case Report ◽  
Influenza A Virus ◽  
Influenza A ◽  
Fatal Case ◽  
Online Version ◽  
Fulminant Myocarditis ◽  
Clinical Centre ◽  
Novi Sad ◽  
Font Color

1. In the Case report titled ?A fatal case of fulminant myocarditis caused by influenza A virus? by Mila Kovacevic, Ilija Srdanovic, Milana Jarakovic, Dragana Bogdanovic, Milenko Cankovic, published in the Vojnosanitetski Pregled 2019; 76(12): 1290-6. (https://doi.org/10.2298/VSP170928017K), there was an error in the byline. The correct byline is: Mila Kovacevic*?, Ilija Srdanovic*?, Milana Jarakovic*, Dragana Bogdanovic*, Golub Samardzija*?, Milenko Cankovic*? *Institute of Cardiovascular Diserases of Vojvodina, Sremska Kamenica, Serbia; ?University of Novi Sad, ?Faculty of Medicine, Novi Sad, Serbia. The correction has been made to the online version of that issue of the Journal which is available at: http://www.vma.mod.gov.rs/vsp12-2019.pdf 2. In the Case report titled ?Psychogenic diabetes insipidus - A case report of behavioral psychotherapy? by Miodrag M. Stankovic, Jelena Stevanovic, Aleksandra Stojanovic, Sandra Stankovic, published in the Vojnosanitetski Pregled 2020; 77(12): 1332-5. (https://doi.org/10.2298/VSP180527188S), there was an error in the byline. The correct byline is: Miodrag M. Stankovic*?, Jelena Stevanovic?, Aleksandra Stojanovic*, Jelena Kostic*?, Sandra Stankovic? University of Nis, *Faculty of Medicine, Nis, Serbia; Clinical Centre Nis, ?Center for Mental Health Protection, ?Clinic for Children?s Internal Diseases, Nis, Serbia; ?General Hospital, Leskovac, Serbia The correction has been made to the online version of that issue of the Journal which is available at: http://www.vma.mod.gov.rs/vsp-12-2020.pdf <br><br><font color="red"><b> Link to the corrected article <u><a href="http://dx.doi.org/10.2298/VSP170928017K">10.2298/VSP170928017K</a></b></u> <br><br><font color="red"><b> Link to the corrected article <u><a href="http://dx.doi.org/10.2298/VSP180527188S">10.2298/VSP180527188S</a></b></u>

Abstract 17075: Impact of Peripheral Artery Disease on Outcomes Following Admission for Cardiogenic Shock

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Nino Mihatov ◽  
Robert W Yeh ◽  
Eunhee Choi ◽  
Changyu Shen ◽  
Sahil A Parikh ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Cardiogenic Shock ◽  
Peripheral Artery Disease ◽  
Circulatory Support ◽  
Complication Rates ◽  
Medicare Beneficiaries ◽  
Peripheral Artery ◽  
Adjusted Risk ◽  
Artery Disease ◽  
The Impact

Introduction: Contemporary in-hospital mortality rates for patients presenting with acute myocardial infarction (AMI) and cardiogenic shock (CS) remain as high as 50%. The impact of comorbid lower extremity peripheral artery disease (LE-PAD) is unknown. Hypothesis: LE-PAD is associated with higher morbidity and mortality in patients presenting with CS and AMI. Methods: Medicare beneficiaries hospitalized with CS related to AMI from 10/2015-6/2017 were identified. PAD status was defined by the inpatient billing codes present in the year prior to presentation. Outcomes included in-hospital mortality, amputation, peripheral revascularization, and 6-month mortality. Adjusted regression models were used to evaluate outcomes. A subgroup analysis included patients requiring mechanical circulatory support (MCS). Results: Among 45,144 patients, 5.9% (N=2,651) had LE-PAD. The average age was 77.8±7.9, 59.8% were male and 83.0% were white. Cumulative in-hospital mortality was 46.8%, with greater risk among LE-PAD patients (55.2% vs 46.3%; adjusted OR 1.52, 95% CI 1.39-1.65). LE-PAD patients also had greater adjusted risk of in-hospital amputation (1.5% vs 0.2%; OR 3.23, 95% CI: 2.16-4.83), peripheral revascularization rates (1.4% vs 0.4%; OR 1.54, 95% CI: 1.06-2.23), and 6-month mortality (43.2% vs 23.7%; HR 2.06, 95% CI: 1.80-2.35). MCS was less frequently utilized in LE-PAD (20.1% vs. 38.1%, p<0.01). Adjusted in-hospital mortality, amputation and peripheral revascularization rates were comparable between LE-PAD and non-LE-PAD patients who received MCS. Non-MCS LE-PAD patients had a 2.28 fold higher adjusted 6-month mortality compared with MCS LE-PAD patients (95% CI 1.60-3.11; Figure). Conclusions: Comorbid PAD is associated with worse limb outcomes and mortality among patients with AMI and CS. Although MCS was less likely to be used in LE-PAD patients, in-hospital mortality and limb complication rates were comparable to non-LE-PAD MCS patients.

scholarly journals Influenza A and B viruses in the population of Vojvodina, Serbia

2014 ◽  
Vol 66 (1) ◽  
pp. 43-50 ◽  
Author(s):  
J. Radovanov ◽  
V. Milosevic ◽  
I. Hrnjakovic ◽  
V. Petrovic ◽  
M. Ristic ◽  
...  
Keyword(s):  
Influenza A ◽  
Respiratory Infections ◽  
Influenza Viruses ◽  
Influenza B Virus ◽  
Nasopharyngeal Swab ◽  
Influenza B ◽  
Influenza A Viruses ◽  
B Virus ◽  
Life Threatening ◽  
Seasonal Epidemic

At present, two influenza A viruses, H1N1pdm09 and H3N2, along with influenza B virus co-circulate in the human population, causing endemic and seasonal epidemic acute febrile respiratory infections, sometimes with life-threatening complications. Detection of influenza viruses in nasopharyngeal swab samples was done by real-time RT-PCR. There were 60.2% (53/88) positive samples in 2010/11, 63.4% (52/82) in 2011/12, and 49.9% (184/369) in 2012/13. Among the positive patients, influenza A viruses were predominant during the first two seasons, while influenza B type was more active during 2012/13. Subtyping of influenza A positive samples revealed the presence of A (H1N1)pdm09 in 2010/11, A (H3N2) in 2011/12, while in 2012/13, both subtypes were detected. The highest seroprevalence against influenza A was in the age-group 30-64, and against influenza B in adults aged 30-64 and >65.

Cardiogenic shock in patients with acute coronary syndromes

2015 ◽  
Author(s):  
Holger Thiele ◽  
Uwe Zeymer
Keyword(s):  
Intensive Care ◽  
Cardiogenic Shock ◽  
Acute Coronary Syndromes ◽  
Artery Bypass ◽  
Left Ventricular ◽  
Circulatory Support ◽  
Intensive Care Treatment ◽  
Post Discharge ◽  
Coronary Syndrome ◽  
Coronary Syndromes

Cardiogenic shock complicating an acute coronary syndrome is observed in up to 10% of patients and is associated with high mortality still approaching 50%. The extent of ischaemic myocardium has a profound impact on the initial, in-hospital, and post-discharge management and prognosis of the cardiogenic shock patient. Careful risk assessment for each patient, based on clinical criteria, is mandatory, to decide appropriately regarding revascularization by primary percutaneous coronary intervention or coronary artery bypass grafting, drug treatment by inotropes and vasopressors, mechanical left ventricular support, additional intensive care treatment, triage among alternative hospital care levels, and allocation of clinical resources. This chapter will outline the underlying causes and diagnostic criteria, pathophysiology, and treatment of cardiogenic shock complicating acute coronary syndromes, including mechanical complications and shock from right heart failure. There will be a major focus on potential therapeutic issues from an interventional cardiologist’s and an intensive care physician’s perspective on the advancement of new therapeutical arsenals, both mechanical percutaneous circulatory support and pharmacological support. Since studying the cardiogenic shock population in randomized trials remains challenging, this chapter will also touch upon the specific challenges encountered in previous clinical trials and the implications for future perspectives in cardiogenic shock.

scholarly journals A fatal case caused by novel H7N9 avian influenza A virus in China

2013 ◽  
Vol 2 (1) ◽  
pp. 1-1 ◽  
Author(s):  
Feifei Yang ◽  
Jiali Wang ◽  
Lin Jiang ◽  
Jialin Jin ◽  
Lingyun Shao ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza A Virus ◽  
Influenza A ◽  
Fatal Case ◽  
Avian Influenza A Virus
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