scholarly journals Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer-controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study

2019 ◽  
Vol 76 (10) ◽  
pp. 1045-1053
Author(s):  
Dejan Cetkovic ◽  
Marija Milic ◽  
Vladimir Biocanin ◽  
Ivana Brajic ◽  
Dejan Calasan ◽  
...  
Keyword(s):  
Heart Rate ◽  
Clinical Study ◽  
Nerve Block ◽  
Dental Treatment ◽  
Onset Time ◽  
Cardiovascular Function ◽  
Double Blind ◽  
Randomized Clinical Study ◽  
Computer Controlled ◽  
Pulpal Anesthesia

Bacground/Aim. The efficient dental anesthesia, which is related to the clinically adequate depth, duration and the width of anesthetic field, is an important prerequisite for successful dental treatment. The aim of this study was to investigate and compare the pulpal anesthesia and cardiovascular parameters after the anterior middle superior alveolar (AMSA) nerve block with 4% articaine with epinephrine administered by conventional cartridge-syringe and computer- controlled local anesthetic delivery system (CCLADS). Methods. This controlled double-blind cross-over randomized clinical study included 38 healthy volunteers. Efficacy of pulpal anesthesia after the AMSA nerve block was evaluated by measuring a success rate, onset and duration of pulpal anesthesia, using an electrical pulp tester. The parameters of cardiovascular function (systolic and diastolic blood pressure, heart rate) were monitored noninvasively. Results. Successful pulpal anesthesia of all tested teeth was obtained in 57.9% participants with CCLADS and in 44.7% participants with conventional syringe. The onset time was not significantly different between two investigated groups. The pulpal anesthesia duration was not significantly different neither within nor between investigated groups. The systolic and diastolic blood pressures were significantly decreased in both investigated groups, in comparison with the baseline values. Heart rate significantly decreased within CCLADS from 10th to 30th minute when compared to baseline. Conclusion. The efficacy of pulpal anesthesia and safety of cardiovascular profile of 0.6 mL of articaine with epinephrine (1:100.000) delivered with CCLADS were improved in comparison to the conventional syringe delivery. Significant changes of cardiovascular function were not observed.

A Comparison of Genicular Nerve Treatment Using Either Radiofrequency or Analgesic Block with Corticosteroid for Pain after a Total Knee Arthroplasty: A Double-Blind, Randomized Clinical Study

Pain Practice ◽  
2016 ◽  
Vol 17 (5) ◽  
pp. 578-588 ◽  
Author(s):  
Salima Qudsi-Sinclair ◽  
Enrique Borrás-Rubio ◽  
Juan F. Abellan-Guillén ◽  
María Luz Padilla del Rey ◽  
Guadalupe Ruiz-Merino
Keyword(s):  
Total Knee Arthroplasty ◽  
Clinical Study ◽  
Knee Arthroplasty ◽  
Double Blind ◽  
Randomized Clinical Study ◽  
Total Knee ◽  
Analgesic Block

Comparison of Clonidine and Epinephrine in Lidocaine for Cervical Plexus Block

1997 ◽  
Vol 22 (2) ◽  
pp. 137-142
Author(s):  
Rowan R. Molnar ◽  
Michael J. Davies ◽  
David A. Scott ◽  
Brendan S. Silbert ◽  
Patricia H. Mooney
Keyword(s):  
Heart Rate ◽  
Carotid Endarterectomy ◽  
Plasma Concentrations ◽  
Prospective Trial ◽  
Onset Time ◽  
Maximum Plasma ◽  
Cervical Plexus ◽  
Double Blind ◽  
Cervical Plexus Block ◽  
Plexus Block

Background and ObjectivesCarotid endarterectomy under cervical plexus block offers the advantage of awake neurologic assessment. The hypothesis was tested that the addition of clonidine 5 μg/mL to lidocaine 1.5% for the block is as effective clinically as the addition of epinephrine 5 μg/mL but without the associated tachycardia.MethodsIn a double-blind, randomized, prospective trial of 40 patients, local anesthetic solutions of lidocaine 1.5% containing either clonidine 5 μg/mL or epinephrine 5 μg/mL were compared for cervical plexus block in patients undergoing carotid endarterectomy. Each solution was administered to 20 patients with a total lidocaine dose of 7 mg/kg. The electrocardiogram, heart rate, and arterial pressure (radial artery catheter) were continuously monitored. Blood samples were drawn for determination of serum lidocaine levels during the first hour.ResultsThe block onset time (8.4 ± 0.6 minutes for epinephrine, 8.8 ± 0.8 minutes for clonidine) and duration (139 ± 6.7 minutes for epinephrine, 148 ± 5.8 minutes for clonidine) were not different between the two groups. During the period from completion of the block until incision there was a significant heart rate increase in the epinephrine group (23% mean rise) as compared with the clonidine group (4% mean rise) (P < .003). There was no difference in blood pressure between the two groups. The maximum plasma concentrations of lidocaine were 2.5-7.6 μg/mL (mean, 4.5 ± 0.3 μg/mL) for the epinephrine group and 4.7-18.4 μg/mL (mean, 7.5 ± 0.7 μg/mL) for the clonidine group (P < .0002). The maximum concentrations were reached 0-30 minutes (mean, 8 ± 1.4 minutes) after injection for the epinephrine group and 0-10 minutes (mean, 4.5 ± 7.1 minutes) for the clonidine group (P < .03).ConclusionsClonidine 5 μg/mL is a useful additive to lidocaine 1.5% for cervical plexus block to reduce the incidence of tachycardia; however, omission of epinephrine results in higher serum lidocaine levels.

Randomized Study of Phentolamine Mesylate for Reversal of Local Anesthesia

2008 ◽  
Vol 87 (7) ◽  
pp. 635-639 ◽  
Author(s):  
M. Laviola ◽  
S.K. McGavin ◽  
G.A. Freer ◽  
G. Plancich ◽  
S.C. Woodbury ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Local Anesthetic ◽  
Dental Treatment ◽  
Randomized Study ◽  
Study Drug ◽  
Negative Consequences ◽  
Double Blind ◽  
Dental Procedures ◽  
Phase 2 Study ◽  
Pulpal Anesthesia

Local anesthetic solutions frequently contain vasoconstrictors to increase the depth and/or duration of anesthesia. Generally, the duration of soft-tissue anesthesia exceeds that of pulpal anesthesia. Negative consequences of soft-tissue anesthesia include accidental lip and tongue biting as well as difficulty in eating, drinking, speaking, and smiling. A double-blind, randomized, multicenter, Phase 2 study tested the hypothesis that local injection of the vasodilator phentolamine mesylate would shorten the duration of soft-tissue anesthesia following routine dental procedures. Participants (122) received one or two cartridges of local anesthetic/vasoconstrictor prior to dental treatment. Immediately after treatment, 1.8 mL of study drug (containing 0.4 mg phentolamine mesylate or placebo) was injected per cartridge of local anesthetic used. The phentolamine was well-tolerated and reduced the median duration of soft-tissue anesthesia in the lip from 155 to 70 min (p < 0.0001).

scholarly journals A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain

2015 ◽  
Vol 26 (4) ◽  
pp. 367-372 ◽  
Author(s):  
Martin Bauer ◽  
Richard Schwameis ◽  
Thomas Scherzer ◽  
Isabelle Lang-Zwosta ◽  
Kanako Nishino ◽  
...  
Keyword(s):  
Clinical Study ◽  
Double Blind ◽  
Randomized Clinical Study
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