scholarly journals Osteoporosis reversibility in a patient with celiac disease and primary autoimmune hypothyroidism on gluten free diet: A case report

2015 ◽  
Vol 72 (1) ◽  
pp. 72-76
Author(s):  
Branka Kovacev-Zavisic ◽  
Tijana Icin ◽  
Jovanka Novakovic-Paro ◽  
Milica Medic-Stojanoska ◽  
Ivana Bajkin
Keyword(s):  
Vitamin D ◽  
Celiac Disease ◽  
Case Report ◽  
Secondary Hyperparathyroidism ◽  
Signs And Symptoms ◽  
Underlying Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Laboratory Findings ◽  
Autoimmune Hypothyroidism

Introduction. Secondary osteoporosis occurs in many diseases. Celiac disease-induced osteoporosis is the consequence of secondary hyperparathyroidism. Biochemical bone markers show predominance of bone resorption, thus making the bisphosphonates the first line therapy option. Intestinal mucosal changes are reversible on gluten-free diet. Osteoporosis reversibility is also possible, provided postmenopausal osteoporosis risk factors independent from celiac disease are not present. Case report. We presented a postmenopausal woman with at least a 10-year history of celiac disease prior to diagnosis, which had overt secondary hyperparathyroidism with insufficient status of vitamin D and a significant bone mass reduction. At the time of diagnosis of celiac disease the patient was receiving 250 ??g of levothyroxine daily without achieving optimal substitution. Three years after the initiation of gluten-free diet the patient was without any signs and symptoms of the disease. All laboratory findings were within normal range. It was decided to treat the underlying disease and to supplement calcium and vitamin D without the initiation of bisphosponate therapy. Conclusion. Osteoporosis regression justified this therapeutic approach. The presence of primary autoimmune hypothyroidism makes this case specific, since the inability for optimal substitution therapy with a high daily dose of levothyroxine provoked the suspicion of celiac disease.

Benefit of gluten-free diet in acrodermatitis continua of Hallopeau associated with celiac disease: a case report

2013 ◽  
Vol 53 (7) ◽  
pp. 897-898
Author(s):  
Cecile Fabre ◽  
Marine Lefèvre ◽  
Michel Dandurand ◽  
Laurent Meunier ◽  
Pierre-Emmanuel Stoebner
Keyword(s):  
Celiac Disease ◽  
Case Report ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals 25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D, and Peripheral Bone Densitometry in Adults with Celiac Disease

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 929 ◽  
Author(s):  
Carolina Ciacci ◽  
Giancarlo Bilancio ◽  
Ilaria Russo ◽  
Paola Iovino ◽  
Pierpaolo Cavallo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Celiac Disease ◽  
Serum Calcium ◽  
Calcium Supplementation ◽  
Quantitative Computed Tomography ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Mineral Density ◽  
High Fracture ◽  
Calcium And Phosphorus

Background: Adults with celiac disease (CeD) show low bone mineral density (BMD) and high fracture risk. CeD guidelines suggest measurements of serum minerals and vitamin D. However, studies on vitamin levels in CeD patients are contradictory. Aim: To investigate in CeD, 25-hydroxy-vitamin D [25(OH)D], 1,25-dihydroxy-vitamin D [1,25(OH)2D], and related analytes and to evaluate their relationships to peripheral BMD as assessed by peripheral quantitative computed tomography (pQCT). Methods: Gluten-free diet (GFD)-treated, and untreated adult CeD patients naïve to vitamin D and calcium supplementation underwent measurements of serum 25(OH)D, 1,25(OH)2D, parathyroid hormone (PTH), total calcium, phosphate, and of radius BMD by pQCT. Results: Complete data were collected in 105 patients for lab tests and 87 patients for BMD. For lab tests, untreated CeD differed from treated CeD for 22.0% lower serum 25(OH)D (p = 0.023), 42.5% higher serum PTH (p < 0.001), and 13.0% higher serum 1,25(OH)2D (p = 0.029) in the presence of similar serum calcium and phosphorus (p > 0.35). For BMD, untreated CeD differed from treated CeD for lower diaphyseal cortical BMD (1133 and 1157 mg/cm3, p = 0.004) but not for distal BMD (total, trabecular, and subcortical, p > 0.13). Independent correlates of diaphyseal cortical BMD were GFD treatment and body mass index (p < 0.05). Conclusions: Data indicated that, compared to CeD patients on a gluten-free diet, untreated adult CeD patients at diagnosis had lower 25(OH)D, higher PTH, and higher 1,25(OH)2D in the absence of difference in serum calcium and phosphorus. 25(OH)D and 1,25(OH)2D, even below the normal range, were not associated with BMD. Our findings do not support the use of vitamin D supplementation for all CeD adults.

scholarly journals CELIAC DISEASE;

2017 ◽  
Vol 24 (08) ◽  
pp. 1253-1255
Author(s):  
Edip Erkus ◽  
Mehmet Zahid Kocak ◽  
Gulali Aktas ◽  
Haluk Savli
Keyword(s):  
Vitamin D ◽  
Immune Response ◽  
Celiac Disease ◽  
Vitamin D Deficiency ◽  
Elderly Woman ◽  
Autoimmune Disorder ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Latent Disease ◽  
Definition Of

Celiac Disease (CD) is an autoimmune disorder based on immune response togluten in genetically predisposed subjects. Five subtypes of CD has been described; classicaldisease, atypical disease, silent disease, latent disease, potential disease. Literature consistsat least five different definition of latent CD. We aimed to present a unique latent CD case inan elderly woman, who referred with anemia, hypoalbuminemia and vitamin D deficiency. Sheresponded well to initiation of gluten free diet.

scholarly journals Intussusception associated with celiac disease in a child: case report and review of literature

2019 ◽  
Vol 6 (3) ◽  
pp. 1402
Author(s):  
Mukesh Kumar ◽  
Diwakar Bansal ◽  
Mohan Lal Parihar
Keyword(s):  
Celiac Disease ◽  
Case Report ◽  
Small Bowel ◽  
Intestinal Obstruction ◽  
Growth Retardation ◽  
Hypochromic Anemia ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Review Of Literature ◽  
Surgical Interventions

Intussusception and celiac disease both are common in children.  Intussusception has been rarely associated with celiac disease in children, which mostly involved small bowel, are transient without classical symptoms, reduced spontaneously and rarely needs intervention. Authors are reporting a 2-year girl who presented initially as gastroenteritis and later on intestinal obstruction and on investigation revealed ileo-ileal intussusception which resolved spontaneously during laparotomy preparation. The patient had growth retardation and microcytic hypochromic anemia and on further evaluation diagnosed with celiac disease. This case report highlights the need of celiac testing in children with intussusception, and such intussusception resolved spontaneously with gluten free diet and rarely needs any active intervention, thus preventing from undue nonsurgical or surgical interventions for intussusception.

scholarly journals Celiac disease - case report

2002 ◽  
Vol 55 (11-12) ◽  
pp. 532-534 ◽  
Author(s):  
Gradimir Bojkovic ◽  
Zorica Caparevic ◽  
Vesna Ilic ◽  
Dragos Stojanovic ◽  
Djordje Lalosevic ◽  
...  
Keyword(s):  
Small Intestine ◽  
Celiac Disease ◽  
Case Report ◽  
Immune System ◽  
Gluten Free Diet ◽  
Intestinal Damage ◽  
Gluten Free ◽  
Intestinal Malabsorption ◽  
X Ray ◽  
Gluten Intolerance

Introduction Celiac disease (nontropical sprue, gluten-sensitive enteropathy, chronic intestinal malabsorption disorder) is caused by gluten intolerance. This hereditary disorder is caused by sensitivity to gliadin. Because the body's own immune system causes the damage, celiac disease is considered to be an autoimmune disorder. However, it is also classified as a disease of malabsorption because nutrients are not absorbed. When people with celiac disease eat foods containing gluten, their immune system responds by damaging the small intestine. Specifically, tiny finger-like protrusions, called villi, on the lining of the small intestine are lost. The diagnosis is suspected on the basis of symptoms and signs, enhanced by laboratory and x-ray studies, and confirmed by biopsy revealing flat mucosa and subsequent clinical and histologic improvement on a gluten-free diet. Gluten must be excluded from diet. Supplementary vitamins, minerals and hematinics may be given depending on deficiency. Case report This is a case report of a 23-year old female patient with a mineralization defect (osteomalacia) and secondary osteoporosis caused by long-time unrecognized celiac disease. The patient had many symptoms: short stature, steatorrhea, anemia, weight loss and chronic bone pain. Laboratory and x-ray studies and jejunal biopsy revealed a chronic intestinal malabsorption disorder caused by gluten intolerance. Gluten-free diet and supplementary vitamins, minerals and hematinics were included with apparent clinical remission. Discussion and Conclusion Some people with celiac disease may not have symptoms. The undamaged part of their small intestine is able to absorb enough nutrients to prevent symptoms. However, people without symptoms are still at risk for complications of celiac disease. Biopsy of the small intestine is the best way to diagnose celiac disease. Decreased bone density (osteoporosis and osteomalacia) is a serious problem for celiacs. If calcium is not absorbed, due to small intestinal damage caused by untreated celiac disease, bones are not as dense. The only treatment for celiac disease is gluten-free diet, that is, avoiding all foods that contain gluten. For most people, this diet stops symptoms, heals the existing intestinal damage, and prevents further damage.

scholarly journals Psychosis and Silent Celiac Disease in a Down Syndrome Adolescent: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Amparo Morant
Keyword(s):  
Down Syndrome ◽  
Celiac Disease ◽  
Case Report ◽  
Psychiatric Symptoms ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Olanzapine Treatment ◽  
Systemic Disorder ◽  
Associated Conditions

Celiac disease is an autoimmune systemic disorder. It presents gastrointestinal and nongastrointestinal manifestations as well as associated conditions. We report a 16-year-old Down syndrome girl who presented psychosis symptomatology, and she was diagnosed as having silent celiac disease. Olanzapine treatment and gluten-free diet were satisfactory. It is necessary to consider celiac disease in Down syndrome patients with psychiatric symptoms, mainly psychotic symptomatology.

The effect of celiac disease and gluten-free diet on pubertal development: a two-center study

2020 ◽  
Vol 33 (3) ◽  
pp. 409-415
Author(s):  
Nevzat Aykut Bayrak ◽  
Burcu Volkan ◽  
Belma Haliloglu ◽  
Soner Sertan Kara ◽  
Atilla Cayir
Keyword(s):  
Vitamin D ◽  
Celiac Disease ◽  
Pubertal Development ◽  
Tanner Stage ◽  
Gonadal Hormones ◽  
Gluten Free Diet ◽  
Age At Menarche ◽  
Gluten Free ◽  
Vitamin D Status ◽  
Healthy Individuals

AbstractObjectivesWe aimed to assess whether age at menarche and pubertal development (Tanner stage) are related to gluten-free diet (GFD) adherence, hormonal status, micro-nutrient levels and body mass index (BMI) in children with celiac disease (CD).MethodsIn this two-center, cross-sectional study, CD patients and healthy individuals were studied. CD patients were re-evaluated after 1 year of follow-up. Height, weight, Tanner stage, age at menarche and diet compliance were recorded. Blood samples for anti-tissue transglutaminase IgA (TTG), pituitary gonadotropins, gonadal hormones, prolactin and micronutrients (folate, vitamin B12, vitamin D, ferritin, iron and, iron-binding capacity [IBC]) were assayed.ResultsConsecutive age- and sex-matched 228 celiac patients (12.92 ± 2.35 years; 67.9% female) and 135 non-celiac healthy individuals (12.77 ± 2.25 years; 65.2% female) were studied. Tanner stage was significantly higher in the control group for both girls and boys (p < 0.05). The mean age at menarche was significantly lower in healthy individuals (13.13 ± 1.01 vs. 12.15 ± 0.97, p < 0.001). By multivariate analysis, GFD adherence, transferrin saturation (sTrf), total IBC (TIBC) and vitamin D status were found to be positively correlated with Tanner stage (p < 0.05). After 1 year, 192 of the CD patients were re-evaluated. GFD compliance was better (TTG levels: 135.59 ± 73.88 vs. 71.53 ± 69.40, p < 0.001) and it was correlated with Tanner stage (r = 0.49, p < 0.01), sTrf (r = 0.66, p < 0.01) and IBC (r = 0.23, p < 0.05).ConclusionsOur data show that adequate weight gain, adherence to GFD, sufficient iron and vitamin D status are essential factors for salubrious puberty in CD patients.

scholarly journals Pernio as the clinical presentation of celiac disease: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2094044
Author(s):  
Alexandre Lemieux ◽  
Natasha Emily Sanchez Vivas ◽  
Julie Powell ◽  
Prévost Jantchou ◽  
Marie-Paule Morin
Keyword(s):  
Celiac Disease ◽  
Case Report ◽  
Pharmacological Treatment ◽  
Clinical Remission ◽  
Clinical Presentation ◽  
Gastrointestinal Symptoms ◽  
Skin Lesions ◽  
Gluten Free Diet ◽  
Gluten Free

We present the case of a 12-year-old girl with severe pernio as the sole clinical presentation of celiac disease (CD), without associated gastrointestinal symptoms. Lesions greatly improved once a gluten free diet was initiated. At 5-year follow-up, she remains in clinical remission throughout the year with no pharmacological treatment, without skin lesions flare-up in the winter months.

Decrease in lactobacilli in the intestinal microbiota of celiac children with a gluten-free diet, and selection of potentially probiotic strains

2015 ◽  
Vol 61 (1) ◽  
pp. 32-37 ◽  
Author(s):  
María J. Lorenzo Pisarello ◽  
Elisa O. Vintiñi ◽  
Silvia N. González ◽  
Florencia Pagani ◽  
Marcela S. Medina
Keyword(s):  
Celiac Disease ◽  
Intestinal Microbiota ◽  
Lactobacillus Rhamnosus ◽  
Signs And Symptoms ◽  
Gluten Free Diet ◽  
Healthy Children ◽  
Gluten Free ◽  
Promising Alternative ◽  
Probiotic Potential ◽  
Probiotic Strains

The intestinal microbiota would be implicated in pathology associated with celiac disease caused by an abnormal immune system reaction against gluten present in cereal grains. The objectives of this work were to detect through basic methods the changes in the composition of the most common genera of bacteria from the intestinal microbiota of symptom-free celiac disease children with a gluten-free diet compared with healthy children from Tucumán and to select lactobacilli (Lb) strains with probiotic potential from the feces of healthy children. Results demonstrated that the feces of celiac children with a gluten-free diet showed significantly lower counts of Lb (P < 0.05) compared with healthy children, while enterobacteria tended to increase in celiac children. On the basis of these results, isolation of some Lb from the feces of healthy children was carried out. Thus, 5 Lb strains were selected because of their high resistance percentages to gastrointestinal tract conditions. In addition, their autoaggregation and hydrophobicity properties were evaluated: Lactobacillus rhamnosus (LC4) showed the highest percentage of autoaggregation while Lactobacillus paracasei (LC9) showed high hydrophobicity. Based on these results, LC4 and LC9 were selected, and their use as potential probiotic strains to improve signs and symptoms associated with celiac disease is discussed. This is the first study performed in Argentina concerning the relationship between intestinal microbiota and celiac disease in celiac children with a gluten-free diet. In addition, the development of a probiotic food addressed towards celiac patients and designed with Lb isolated from the feces of healthy children from our province represents a promising alternative to improve the quality of life of celiac patients.

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