scholarly journals Matrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabetics

2015 ◽  
Vol 72 (5) ◽  
pp. 421-426 ◽  
Author(s):  
Srdjan Popovic ◽  
Fadil Canovic ◽  
Miroljub Ilic ◽  
Saso Rafajlovski ◽  
Vesna Dimitrijevic-Sreckovic ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Matrix Metalloproteinase ◽  
Plaque Rupture ◽  
Study Groups ◽  
Matrix Metalloproteinase 9 ◽  
Atheromatous Plaque ◽  
Diabetic Patients ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
Metalloproteinase 9

Background/Aim. Matrix metalloproteinase-9 (MMP-9) index is the ratio of active MMP-9 and total MMP-9 levels. It reflects the importance of MMP-9 in acute coronary syndrome (ACS). Methods. The study included 3 groups of patients (n = 87): the group 1 - non-diabetic subjects without ACS (control); the group 2 - diabetic patients with ACS [subgroups with unstable angina pectoris (UAP), myocardial infarction (MI) or reinfarction]; and the group 3 non-diabetics patients with ACS. Total and active MMP-9 were measured and used to create MMP-9 index. Results. MMP-9 index, as a marker showed good sensitivity and specificity, of ACS in diabetics, with a cut-off value over 58.2. MMP-9 was higher in the study groups than in the control one. MMP-9 correlated with ACS occurrence and type of cardiovascular event. A statistically significant difference was found among the groups according to active MMP-9 (p < 0.001). The same was found with active MMP-9 between the control and the group with MI (p < 0.001). The control was highly statistically significantly different from the group of patients with UAP (p < 0.01). Statically significant differences in MMP-9 index was found between the control and the diabetics with ACS (p < 0.001). Statistically significant difference of MMP-9 index was also found in the controls compared to the value in non-diabetic patients with ACS (p < 0.01). Conclusion. MMP-9 index may be a possible marker of atheromatous plaque rupture in diabetics.

Matrix Metalloproteinase-9 as a Marker for Plaque Rupture and a Predictor of Adverse Clinical Outcome in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study

Cardiology ◽  
2016 ◽  
Vol 135 (1) ◽  
pp. 56-65 ◽  
Author(s):  
Nobuaki Kobayashi ◽  
Masamichi Takano ◽  
Noritake Hata ◽  
Noriaki Kume ◽  
Masafumi Tsurumi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Acute Coronary Syndrome ◽  
Matrix Metalloproteinase ◽  
Plaque Rupture ◽  
Matrix Metalloproteinase 9 ◽  
Plaque Morphology ◽  
Optical Coherence ◽  
Coronary Syndrome ◽  
Creatine Kinase Mb ◽  
Metalloproteinase 9

Objectives: The present study sought to clarify the relationship between matrix metalloproteinase-9 (MMP-9) levels and plaque morphology demonstrated by optical coherence tomography (OCT), and to examine their prognostic impacts in patients with acute coronary syndrome (ACS). Methods: MMP-9 levels were measured for patients with ACS (n = 249). Among 249 patients, 120 with evaluable OCT images were categorized into patients with ruptured plaques (n = 65) and those with nonruptured plaques (n = 55) on the basis of culprit lesion plaque morphology demonstrated by OCT. Results: MMP-9 levels on admission were significantly higher in the rupture group than in the nonrupture group (p = 0.029). Although creatine kinase-MB (CK-MB) on admission was comparable between the groups, peak CK-MB was higher in the rupture group than in the nonrupture group (p < 0.001). By receiver operating characteristic curve analysis, the optimal cut-off value of MMP-9 to detect ruptured plaques was 65.5 ng/ml (p = 0.029). There was a nonstatistically significant trend toward increased cardiac death at 2 years (5.9 vs. 1.0%, p = 0.059) in patients with high MMP-9 (≥65.5 ng/ml) compared to those with low MMP-9 (<65.5 ng/ml). Conclusions: MMP-9 can differentiate ACS with ruptured plaques from nonruptured plaques, and MMP-9 may be a valuable predictor of long-term cardiac mortality in patients with ACS reflecting plaque rupture.

Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome

2010 ◽  
Vol 143 (1) ◽  
pp. 98-100 ◽  
Author(s):  
Alex Bittner ◽  
Hernán Alcaíno ◽  
Pablo F. Castro ◽  
Osvaldo Pérez ◽  
Ramón Corbalán ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Coronary Syndrome ◽  
Metalloproteinase 9

scholarly journals Atorvastatin Lowers Plasma Matrix Metalloproteinase-9 in Patients with Acute Coronary Syndrome

2004 ◽  
Vol 50 (4) ◽  
pp. 750-753 ◽  
Author(s):  
Zhumei Xu ◽  
Shuiping Zhao ◽  
Hongnian Zhou ◽  
Huijun Ye ◽  
Jiang Li
Keyword(s):  
Acute Coronary Syndrome ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Coronary Syndrome ◽  
Metalloproteinase 9

The role of serum levels of microRNA-21 and matrix metalloproteinase-9 in patients with acute coronary syndrome

2016 ◽  
Vol 422 (1-2) ◽  
pp. 51-60 ◽  
Author(s):  
Faramarz Darabi ◽  
Mahmoud Aghaei ◽  
Ahmad Movahedian ◽  
Ali Pourmoghadas ◽  
Nizal Sarrafzadegan
Keyword(s):  
Acute Coronary Syndrome ◽  
Matrix Metalloproteinase ◽  
Serum Levels ◽  
Matrix Metalloproteinase 9 ◽  
Coronary Syndrome ◽  
Metalloproteinase 9
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