scholarly journals Quantitative analysis of dendritic branching pattern of large neurons in human cerebellum

2010 ◽  
Vol 67 (9) ◽  
pp. 712-716 ◽  
Author(s):  
Nebojsa Milosevic ◽  
Dusan Ristanovic ◽  
Dusica Maric ◽  
Radmila Gudovic ◽  
Bojana Krstonosic
Keyword(s):  
Quantitative Analysis ◽  
Dentate Nucleus ◽  
Morphometric Parameter ◽  
Branching Pattern ◽  
Fractal Analyses ◽  
Significant Difference ◽  
Branching Patterns ◽  
Dendritic Branching ◽  
Human Cerebellum ◽  
Large Neurons

Background/Aim. Dentate nucleus (nucleus dentatus) is the most distant of the cerebellar nuclei and the major system for information transfer in the cerebellum. So far, dendritic branches of four different kinds of large neurons of dentate nucleus, have been considered mainly qualitatively with no quantification of their morphological features. The aim of the study was to test the qualitative hypothesis that the human dentate nucleus is composed of various types of the large neurons by quantitative analysis of their dendritic branching patterns. Methods. Series of horizontal sections of the dentate nuclei were taken from 15 adult human brains, free of diagnosed neurological disorders. The 189 Golgi-impregnated images of large neurons were recorded by a digital camera connected to a light microscope. Dendritic branching patterns of digitized neuronal images were analyzed by modified Sholl and fractal analyses. Results. The number of intersections (Nm), critical radius (rc) and fractal dimension (D) of dendritic branching pattern for four types of the large neurons were calculated, statistically evaluated and analyzed. The results show that there is a significant difference between four neuronal types in one morphometric parameter at least. Conclusion. The present study is the first attempt to analyze quantitatively the dendritic branching pattern of neurons from the dentate nucleus in the human. The hypothesis that the four types of the large neurons exist in this part of human cerebellum is successfully supported.

Morphology and classification of large neurons in the adult human dentate nucleus: A qualitative and quantitative analysis of 2D images

2010 ◽  
Vol 67 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Dušan Ristanović ◽  
Nebojša T. Milošević ◽  
Bratislav D. Stefanović ◽  
Dušica L. Marić ◽  
Katarina Rajković
Keyword(s):  
Quantitative Analysis ◽  
Dentate Nucleus ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Adult Human ◽  
Large Neurons ◽  
2D Images

PYRAMIDAL NEURONES IN MACAQUE VISUAL CORTEX: INTERAREAL PHENOTYPIC VARIATION OF DENDRITIC BRANCHING PATTERNS

Fractals ◽  
2001 ◽  
Vol 09 (03) ◽  
pp. 287-295 ◽  
Author(s):  
HERBERT F. JELINEK ◽  
GUY N. ELSTON
Keyword(s):  
Fractal Dimensions ◽  
Pyramidal Cells ◽  
Visual Area ◽  
Cortical Areas ◽  
Area V2 ◽  
Fractal Analyses ◽  
Branching Patterns ◽  
Dendritic Branching ◽  
Dendritic Arbors ◽  
Extrastriate Areas

The basal dendritic arbors of over 500-layer III pyramidal neurones of the macaque cortex were compared by fractal analyses, which provides a measure of the space filling (or branching pattern) of dendritic arbors. Fractal values (D) of individual cells were compared between the cytochrome oxidase (CO)-rich blobs and CO-poor interblobs of middle and upper layer III, and between sublaminae, in the primary visual area (V1). These data were compared with those in the CO compartments in the second visual area (V2), and seven other extrastriate cortical areas (V4, MT, LIP, 7a, TEO, TE and STP). There were significant differences in the fractal dimensions, and therefore the dendritic branching patterns, of cells in striate and extrastriate areas. Of the 55 possible pairwise comparisons of fractal dimension of neurones in different cortical areas (or CO compartments), 39 proved to be significantly different. The markedly different morphologies of pyramidal cells in the different cortical areas may be one of the features that determine the functional signatures of these cells by influencing the number of inputs received by, and propagation of potentials through, their dendritic arbors.

scholarly journals Is the use of contraceptives associated with periodontal diseases? A systematic review and meta-analyses

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Micaele Maria Lopes Castro ◽  
Maria Karolina Martins Ferreira ◽  
Iasmin Encaua Essashika Prazeres ◽  
Paula Beatriz de Oliveira Nunes ◽  
Marcela Baraúna Magno ◽  
...  
Keyword(s):  
Systematic Review ◽  
Quantitative Analysis ◽  
Periodontal Diseases ◽  
Hormonal Contraceptive ◽  
Cochrane Library ◽  
Hormonal Contraceptives ◽  
Clinical Parameters ◽  
Significant Difference ◽  
Meta Analyses ◽  
The Impact

Abstract Background Previous studies indicated an impact of hormonal contraceptive use on oral health. This systematic review aimed to investigate the evidence supporting the impact of the use of hormonal contraceptives and periodontal diseases. Methods This study is based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and based on the PECO acrostic. Inclusion criteria comprised observational studies including women (P), which evaluated hormonal contraceptive users (E) and hormonal contraceptive non-users (C), to verify the association between this hormonal therapy and the periodontal diseases (O). Searches were performed on 5 databases: PubMed, Scopus, Web of Science, Cochrane Library, LILACS and grey literature (OpenGrey and Google Scholar). After the selection process, the included studies were evaluated qualitatively. Moreover, quantitative data were analyzed in two meta-analyses for clinical attachment loss (CAL) and probing depth (PD). Finally, the level of certainty was measured with the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) tool between periodontal clinical parameters. Results 18 articles were eligible for the qualitative synthesis and 7 of them were selected for quantitative analysis. Hence, 15 of the eligible articles reported an association between the use of hormonal contraceptives and severity of periodontal disease. However, 6 articles demonstrated high risk of bias and were excluded from quantitative synthesis. The meta-analysis showed a statistically significant difference for CAL (MD 0.24 [0.09, 0.40]; p = 0.002), but in PD (MD 0.05 [− 0.05, 0.15]; p = 0.33) such difference was not identified. A very low level of evidence was found between the clinical parameters. Conclusions The use of hormonal contraceptives may be associated to severity of periodontal diseases. However, the quantitative analysis points to an inconclusive outcome due to the high level of heterogeneity. The association is biologically plausible, however additional studies are warranted to better elucidate the clinical significance of this possible association.

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