scholarly journals The value of sentinel lymphadenectomy in radical operative treatment of cervical cancer

2009 ◽  
Vol 66 (7) ◽  
pp. 539-543 ◽  
Author(s):  
Vladimir Pazin ◽  
Svetlana Dragojevic ◽  
Zeljko Mikovic ◽  
Milan Djukic ◽  
Snezana Rakic ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Nodes ◽  
Sentinel Node ◽  
Cervical Carcinoma ◽  
Radical Hysterectomy ◽  
Predictive Value ◽  
Sentinel Nodes ◽  
Sentinel Lymphadenectomy ◽  
Stage Ib ◽  
The Mean

Background/Aim. Therapy of the early stages of cervical carcinoma is surgical or radiation therapy, and for advanced stages chemoradiotherapy. Pelvic and paraaortic lymphadenectomy in early stages offers the most important prognostic factor for survival. To evaluate the method and possible influence on surgical staging and therapy of the disease, we performed sentinel node (SN) identification and excision during open radical hysterectomy and lymphadenectomy in stage Ib-IIa cervical carcinoma. Methods. Fifty patients initially diagnosed with invasive squamous-cell cervical cancer stage Ib-IIa were included in the study. Only blue dye was used for sentinel node mapping. During the surgery sentinel nodes were identified and sent to histopathology separately from the other lymph nodes. After lymphadenectomy, radical hysterectomy was performed. Results. The mean age of our fifty patients was 49.10 years (SD = 5.92), and the mean number of extracted lymph nodes per patient was 25.78 (SD = 5.58). The number of sentinel nodes identified per patient was between 0 and 5, mean 2.60 (SD = 1.54). There were no inframesenteric paraaortic sentinel nodes found among the patients. The dominant tumor grades were 1 and 2, 40% and 50% respectively, and 37 out of 50 patients (74%) had tumor diameter less than 2 cm. In four patients (8%) SN were not identified. In the rest of 46 patients the presence of SN was bilateral (19 patients, 38%) or unilateral (27 patients, 54%). Positive SN were found in 17 patients (34%), and negative in 29 patients (58%). Out of the whole group of patients (50), 21 of them (42%) had positive lymph nodes (LN). In the crosstab statistics, no differences were noticed in the group without SN found, in comparison with tumor grade and diameter. Finally, our test showed sensitivity of 85% (SE = 8%), specificity 100%, positive predictive value of 100%, negative predictive value of 89.6% (SE = 5.6%), and effectiveness of 93% (SE = 3.6%) regarding sentinel lymphadenectomy. Conclusion. This method of sentinel lymph node identification is simple, but not reliable enough to support further laparoscopic SN excision in order to make the final decision about the treatment of cervical cancer.

Comparison of Laparoscopic Versus Abdominal Radical Hysterectomy for FIGO Stage IB and IIA Cervical Cancer With Tumor Diameter of 3 cm or Greater

2014 ◽  
Vol 24 (2) ◽  
pp. 280-288 ◽  
Author(s):  
Tae Wook Kong ◽  
Suk-Joon Chang ◽  
Jisun Lee ◽  
Jiheum Paek ◽  
Hee-Sug Ryu
Keyword(s):  
Cervical Cancer ◽  
Radical Hysterectomy ◽  
Operating Time ◽  
Figo Stage ◽  
Tumor Diameter ◽  
Pelvic Magnetic Resonance Imaging ◽  
Laparoscopic Radical Hysterectomy ◽  
Stage Ib ◽  
Estimated Blood Loss ◽  
The Mean

ObjectiveThere have been many comparative reports on laparoscopic radical hysterectomy (LRH) versus abdominal radical hysterectomy (ARH) for early-stage cervical cancer. However, most of these studies included patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA2 and small (tumor diameter ≤2 or 3 cm) IB1 disease. The purpose of this study was to compare the feasibility, morbidity, and recurrence rate of LRH and ARH for FIGO stage IB and IIA cervical cancer with tumor diameter of 3 cm or greater.Materials and MethodsWe conducted a retrospective analysis of 88 patients with FIGO stage IB and IIA cervical cancer with tumor diameter of 3 cm or greater. All patients had no evidence of parametrial invasion and lymph node metastasis in preoperative gynecologic examination, pelvic magnetic resonance imaging, and positron emission tomography–computed tomography, and they all underwent LRH or ARH between February 2006 and March 2013.ResultsAmong 88 patients, 40 patients received LRH whereas 48 underwent ARH. The mean estimated blood loss was 588.0 mL for the ARH group compared with 449.1 mL for the LRH group (P< 0.001). The mean operating time was similar in both groups (246.0 minutes in the ARH vs 254.5 minutes in the LRH group,P= 0.589). Return of bowel motility was observed earlier after LRH (1.8 vs 2.2 days,P= 0.042). The mean hospital stay was significantly shorter for the LRH group (14.8 vs 18.0 days,P= 0.044). There were no differences in histopathologic characteristics between the 2 groups. The mean tumor diameter was 44.4 mm in the LRH and 45.3 mm in the ARH group. Disease-free survival rates were 97.9% in the ARH and 97.5% in the LRH group (P= 0.818).ConclusionsLaparoscopic radical hysterectomy might be a feasible therapeutic procedure for the management of FIGO stage IB and IIA cervical cancer with tumor diameter of 3 cm or greater. Further randomized studies that could support this approach are necessary to evaluate long-term clinical outcome.

Stage IB and IIA Cervical Cancer with Negative Lymph Nodes: The Role of Adjuvant Radiotherapy after Radical Hysterectomy

1997 ◽  
Vol 66 (1) ◽  
pp. 31-35 ◽  
Author(s):  
John O. Schorge ◽  
Kelly L. Molpus ◽  
Daniel Koelliker ◽  
Najmosama Nikrui ◽  
Annekathryn Goodman ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Nodes ◽  
Radical Hysterectomy ◽  
Adjuvant Radiotherapy ◽  
Stage Ib ◽  
Negative Lymph Nodes

scholarly journals Survival Rate Analysis of Early Stage Cervical Cancer Patients after Radical Hysterectomy in Ulin Banjarmasin General Hospital, Indonesia

2021 ◽  
Vol 17 (1) ◽  
pp. 39
Author(s):  
Setyo Teguh ◽  
Hariadi Hariadi ◽  
Ferry Armanza ◽  
Hermin Sabaruddin
Keyword(s):  
Cervical Cancer ◽  
Survival Rate ◽  
Cervical Carcinoma ◽  
Radical Hysterectomy ◽  
Early Stage ◽  
P Value ◽  
Chi Square ◽  
Average Life Span ◽  
Stage Ib ◽  
Rate Analysis

Abstract: Cervical cancer is a gynecologic disease that has a high level of malignancy and is a major cause of death from cancer in women. To be used as educational material for patients with cervical carcinoma when if there is known outcome of radical hysterectomy in patients with IB-IIA cervical carcinoma, it can be used as a basic data to know the success rate of radical hysterectomy.The sample was collected by consecutive sampling and we found a total of 55 IB-IIA cervical carcinoma patients who underwent a radical hysterectomy. The samples that met the inclusion criteria are 30 people. Data analysis using Chi-square/Fisher method (significant p-value <0.05).In this study, 16.7% of patients with cervical carcinoma from IB to IIA died in 3 years after radical hysterectomy was performed. The average age of patients with stage IB to IIA cervical carcinoma was 48.03 ± 12.21 years with ages ranging from 23 to 78 years. Stage IIA is 16 times more significantly at risk for mortality in cervical carcinoma patients than stage IB. The 3-year survival rate for patients with stage IB to IIA cervical carcinoma after radical hysterectomy was 83.3% with an average life span of 32.8 months. Patients with stage IB to IIA cervical carcinoma after radical hysterectomy have an average disease-free interval (DFI) of 33.0 ± 5.74 months. Keywords: Cervical Cancer, Radical Hysterectomy, Survival Rate

Bulky Stage IB Cervical Carcinoma Managed by Primary Radical Hysterectomy Followed by Tailored Radiotherapy

1993 ◽  
Vol 48 (4) ◽  
pp. 266-268
Author(s):  
JEFFREY D. SLOSS ◽  
MICHAEL L. BERMAN ◽  
J. MUKHERERJEE ◽  
ALBERTO MANETTA ◽  
DENNIS EMMA ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Radical Hysterectomy ◽  
Primary Radical ◽  
Stage Ib

Comparison of Papanicolaou Test With Visual Detection Tests in Screening for Cervical Cancer and Developing the Optimal Strategy for Low Resource Settings

2010 ◽  
Vol 20 (5) ◽  
pp. 862-868 ◽  
Author(s):  
Pakhee Aggarwal ◽  
Swaraj Batra ◽  
Gauri Gandhi ◽  
Vijay Zutshi
Keyword(s):  
Cervical Cancer ◽  
Predictive Value ◽  
Visual Inspection ◽  
Visual Detection ◽  
Alternative Methods ◽  
Papanicolaou Test ◽  
Low Resource Settings ◽  
Low Resource ◽  
The Mean ◽  
Sensitivity Specificity

Objectives:To compare the sensitivity, specificity, positive and negative predictive values, and accuracy of Papanicolaou test with visual inspection with acetic acid (VIA)/VIA using magnification devices (VIAM) and develop the best strategy for screening in low resource settings.Materials and Methods:This is a prospective cross-sectional study on 408 symptomatic multiparous women in the reproductive age group, sequentially using the Papanicolaou test, the VIA, and the VIAM for screening. Women with a positive screening test underwent guided biopsy and endocervical curettage. The site of biopsy was recorded. Histopathological findings were taken as the "gold" standard in comparing the methods.Results:The mean (SD) age was 32.3 (6.8) years (range, 15-49 years), whereas the mean (SD) parity was 2.9 (1.2) (range, 1-9). Abnormal cytological findings were detected in 2.9% patients, whereas the remaining smears were negative for any intraepithelial lesion or malignancy. A total of 113 cases were screened positive by one/all methods. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the Papanicolaou test, the VIA, and the VIAM were 24, 98, 42, 96, and 94%; 95, 78, 19, 99, and 79%; and 95, 78, 19, 99, and 79%, respectively, for high-grade lesions.Conclusions:The Papanicolaou test had low sensitivity but high specificity, whereas visual detection methods had a high sensitivity in addition to being cheaper. Alternative methods of screening such as VIA/VIAM can be a valuable alternative to the Papanicolaou test for cervical cancer screening in low resource settings. Visual inspection using magnification devices may be of benefit over VIA in doubtful cases.

Sentinel node detection with radiocolloid lymphatic mapping in early invasive cervical cancer

2005 ◽  
Vol 15 (2) ◽  
pp. 273-277 ◽  
Author(s):  
Y. S. Lin ◽  
C. C. Tzeng ◽  
K. F. Huang ◽  
C. Y. Kang ◽  
C. C. Chia ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Node ◽  
Lymph Node Metastases ◽  
Lymphatic Mapping ◽  
Invasive Cervical Cancer ◽  
False Negative ◽  
Sentinel Node Detection ◽  
Sentinel Nodes ◽  
Node Metastases

We assessed the feasibility of sentinel lymph node detection using technicium-99 radiocolloid lymphatic mapping for predicting lymph node metastases in early invasive cervical cancer. Thirty patients with cervical cancer (stages IA2–IIA) underwent preoperative lymphoscintigraphy using technicium-99 intracervical injection and intraoperative lymphatic mapping with a handheld gamma probe. After dissection of the sentinel nodes, the standard procedure of pelvic lymph node dissection and radical hysterectomy was performed as usual. The sentinel node detection rate was 100% (30/30). There were seven (23.3%) cases of microscopic lymph node metastases on pathologic analysis. All of them had sentinel node involvement. Therefore, the sensitivity of sentinel node identification for prediction of lymph node metastases was 100%, and no false negative was found. Preoperative lymphoscintigraphy, coupled with intraoperative lymphatic mapping, located the sentinel nodes accurately in our study patients. This sentinel node detection method appears to be feasible for predicting lymph node metastases

Preoperative nomogram for prediction of microscopic parametrial infiltration in patients with FIGO stage IB cervical cancer treated with radical hysterectomy

2016 ◽  
Vol 142 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Tae-Wook Kong ◽  
Jayoun Kim ◽  
Joo-Hyuk Son ◽  
Seong Woo Kang ◽  
Jiheum Paek ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Radical Hysterectomy ◽  
Figo Stage ◽  
Stage Ib
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