scholarly journals Frequency and characteristics of metabolic disorders in patients on haemodialysis

2008 ◽  
Vol 65 (3) ◽  
pp. 205-209 ◽  
Author(s):  
Radojica Stolic ◽  
Goran Trajkovic ◽  
Vladan Peric ◽  
Aleksandar Jovanovic ◽  
Dragica Stolic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Renal Insufficiency ◽  
Body Mass ◽  
Fat Body ◽  
Heart Diseases ◽  
Smoking Habit ◽  
Systolic Pressure ◽  
Etiological Factor ◽  
Chronic Haemodialysis

Background/Aim. Metabolic syndrome and malnutrition represent metabolic abnormalities which significantly characterize patients on haemodialysis. The aim of the study was to determine the incidence and find characteristics of metabolic disbalance in patients on haemodialysis. Methods. The study involved 124 patients on chronic haemodialysis at the Clinical Centre Kragujevac. There were analyzed demographic and anthropometric characteristics of the examined patients. Of clinical characteristics, there were determined smoking habit, time on dialysis, arterial pressure; of comorbide states there were recorded heart diseases and diabetes mellitus. Routine biochemical analyses were carried out by a standard laboratory procedure. Results. Metabolic syndrome was found in 29.8% of the examined patients. The patients with metabolic syndrome were older as compared to the patients without metabolic syndrome (58.45?12.91 vs 52.25?11.63 years). The values of systolic pressure (143.88?19.75 vs 133.01?22.93 mmHg; p = 0.014), body mass index (21.2?3.71 vs 19.4?2.88 kg/m2; p = 0.001), fat body mass (19.57?8.47 vs 16.45?5.82%; p = 0.0002) and waist scope (89?12.54 vs 96?12.34 cm; p = 0.0001) were significantly higher in the patients with metabolic syndrome as compared to those without metabolic syndrome. The values of erythrocytes (3.4?0.45 vs 19?0.53 ? 1012; p = 0.04) and hemoglobin (107?15.76 vs 101?13.87 g/l; p = 0.009), glycaemia (9.5?8.15 vs 5.6?1.4 mmol/l; p = 0.04) triglycerides (2.44?1.8 vs 1.41?0.64 mmol/l; p = 0.007), HDL cholesterol (1.11?0.19 vs 0.82?0.25 mmol/l; p = 0.005) and albumins (32.5?5.6 vs 29.5?3.7 g/l; p = 0.007) were statistically higher in the patients with metabolic syndrome than in patients without disturbance. Diabetes mellitus was a significant etiological factor of renal insufficiency in the patients with metabolic syndrome (p = 0.008). Conclusion. In our study approximately 30% of patients on haemodialysis had pronounced metabolic syndrome. The older, more obese men with increased levels of triglycireds and glucose in the serum dominated among them. Diabetes mellitus was a leading etiological factor of renal insufficiency in these patients.

scholarly journals Development of Regional Strategic Framework for Nutrition Action Plan as a tool for Health and Nutrition Diplomacy of the Prevention of Non-Communicable Disease (NCD) in ASEAN Countries

2020 ◽  
Vol 4 (1) ◽  
pp. 119-125
Author(s):  
Sugeng Eko Irianto ◽  
Yudhinanto Yudhinanto
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass ◽  
Communicable Disease ◽  
Action Plan ◽  
Nutrition Transition ◽  
Smoking Habit ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Sugar Consumption ◽  
Asean Countries

The trend of prevalence of Non-Communicable Diseases (NCD) such as hypertension, cardiovascular diseases, diabetes mellitus, and cancer has increased for the last few decades among low and midle income-countries including Indonesia. Based on the results of Basic Health Resarch performed in Indonesia in 2013, the prevalence of hypertension was 25.8 %, diabetes mellitus was 6.9 %, central obesity was 26.6 %, and stroke was 1.2 %. The cause of NCD is multi-factorial and the main risk factors are high consumption of sugar, salt, and fat, low consumption of vegetables and fruit, overweight, lack of physical activity, and smoking habit. Lower income countries such as Indonesia are beginning to experience disease patterns like high-income countries, as more processed foods are incorporated into diets in a nutrition transition, with less of the necessary healthcare resources to cope with increased disease burden. Globally, obesity or Body Mass Index (BMI) greater than 30 kg/m2 was estimated to have been the cause of 3.4 million deaths in 2010. Excess sugar consumption, particularly consumption of sugar-sweetened beverages (SSBs) is a well- documented, significant causal factor for weight gain. Several studies have found increases in BMI per additional daily serve of SSB and decreases in BMI when SSB consumption is reduced. Excess body mass is a significant risk factor for many NCDs such as ischemic heart disease (IHD), stroke, type 2 diabetes mellitus (T2DM) and various cancers, with the associated morbidity and mortality contributing to rising healthcare costs and reduced productivity. Excess sugar consumption directly increases   the risk of T2DM, mediated through both the risk due to higher weight and directly through inflammatory mechanisms triggered by elevated blood sugars.

Incidence of Non-Alcoholic Fatty Liver Disease and Associated Risk Factors

2021 ◽  
Vol 15 (11) ◽  
pp. 3247-3251
Author(s):  
Yar Muhammad Tunio ◽  
Ruqayya Farhad ◽  
Abdul Rashid ◽  
Najeeb Ullah Ansari ◽  
Sadia Chaudhary ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Blood Sugar ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
Female Gender ◽  
The Mean

Objectives: To evaluate the frequency of different risk profiles and associated clinical parameters in patients with nonalcoholic fatty liver disease (NAFLD). Methodology: This cross-sectional study was conducted at the Gambat Institute Of Medical Sciences,Gambat District, Khairpur, between March 2019 to January 2020. A total of 345 patients participated in the study. Demographics, clinical features, investigations, and causative agents of NAFLD were noted in a document. Patients with raised ALT, fatty liver on imaging, aged between 18-75 years were a part of the study. Exclusion criteria included patients with overconsumption of alcohol, positive HBsAg, positive anti-HCV, and other underlying liver diseases with known origin. Patients’ blood samples were also tested for fasting blood sugar, random blood sugar, fasting cholesterol and fasting triglyceride levels.Levels of glucose, triglycerides and cholesterol were measured with an autoanalyzer; Photometer 4010; Beohrnger Mannheim; using the enzymatic-calorimetric methods. All data was analyzed using SPSS version 24. Results: The mean age of the patient was 48.4 ± 12.2 years and a mean body mass index of 30.2 The mean cholesterol was 199.4 ± 54.3 mg/dl. The majority i.e. > 60 percent were women with only 128 (37.1%) males (Table 1). The body mass index (BMI) was significantly higher in female patients as compared to males (p<0.001). The males had a significantly greater frequency of traits for metabolic syndrome as compared to women i.e. 111 (86.7%) vs. 145 (66.8%) (p=0.02). Obesity in patients was also significantly associated with female gender. We found a significant relationship of hypercholesterolemia in patients with DMT2 (p=0.04). Similarly, the majority of the patients i.e. 55 (47%) with DMT2 also had hypertriglyceridemia (p=0.002). Conclusion: The present study indicated that female gender, obesity, and diabetes mellitus were significantly associated with NAFLD. NAFLD places a significant burden on the healthcare system and is associated with poor quality of life of patients. Metabolic syndrome is another leading association that needs to be explored in further detail. Recognition of high-risk profile patients can help establish early diagnosis and hence treatment plans can be implemented at an early stage of disease. Keywords: fatty liver, chronic liver disease, non-alcoholic liver disease, NAFLD, obesity, diabetes mellitus, dyslipidemia

scholarly journals Light to Moderate Alcohol Consumption Is Protective for Type 2 Diabetes Mellitus in Normal Weight and Overweight Individuals but Not the Obese

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Patricia A. Metcalf ◽  
Robert K. R. Scragg ◽  
Rod Jackson
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Type 2 Diabetes Mellitus ◽  
Alcohol Consumption ◽  
Body Mass ◽  
Smoking Habit ◽  
Normal Weight ◽  
Relative Risks

Objective. To examine the association between alcohol consumption and risk of type 2 diabetes mellitus (T2DM) overall and by body mass index.Methods. Cross-sectional study of employed individuals. Daily alcohol intakes were calculated from a self-administered food frequency questionnaire by 5,512 Maori, Pacific Island, and European workers (3,992 men, 1520 women) aged 40 years and above.Results. There were 170 new cases of T2DM. Compared to the group with no alcohol consumption and adjusting for age, sex, and ethnicity, the group consuming alcohol had relative risks of T2DM of 0.23 (95% CI: 0.08, 0.65) in normal weight individuals, 0.38 (0.18, 0.81) in overweight individuals, and 0.99 (0.59, 1.67) in obese individuals. After further adjusting for total cholesterol, HDL-cholesterol, triglycerides, smoking habit, physical activity, socioeconomic status, body mass index, and hypertension, the relative risks of T2DM were 0.16 (0.05, 0.50) in normal weight individuals, 0.43 (0.19, 0.97) in overweight individuals, and 0.92 (0.52, 1.60) in overweight individuals. Across the categories of alcohol consumption, there was an approximate U-shaped relationship for new cases of T2DM. There was no significant association between alcohol consumption and IGT.Conclusions. Alcohol consumption was protective against diagnosis of T2DM in normal and overweight individuals but not in the obese.

scholarly journals Association between Body Mass Index and Core Components of Metabolic Syndrome in 1486 Patients with Type 1 Diabetes Mellitus in Japan (JDDM 13)

2008 ◽  
Vol 55 (6) ◽  
pp. 1025-1032 ◽  
Author(s):  
Keiko ARAI ◽  
Hiroki YOKOYAMA ◽  
Fuminobu OKUGUCHI ◽  
Katsuya YAMAZAKI ◽  
Hirofumi TAKAGI ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Body Mass ◽  
Core Components

scholarly journals Is There an Effect of Methyl Donor Nutrient Supplementation on Metabolic Syndrome in Humans?

2020 ◽  
Vol 8 (1) ◽  
pp. 2
Author(s):  
Naser A. Alsharairi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiometabolic Risk ◽  
Heart Diseases ◽  
Insulin Resistance Syndrome ◽  
World Health ◽  
Nutrient Supplementation ◽  
Coronary Heart Diseases ◽  
Health Organization

Metabolic syndrome (MetS), also termed insulin resistance syndrome, has been defined by World Health Organization (WHO) as a multi-factorial disorder characterized by a wide array of cardiometabolic risk factors that increase the risk of coronary heart diseases, diabetes mellitus, and stroke [...]

scholarly journals Comparison of body mass index and lipid accumulation product as a better indicator of metabolic syndrome

2017 ◽  
Vol 4 (3) ◽  
pp. 728 ◽  
Author(s):  
Yashavanth H. S. ◽  
Bharath M. S.
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Lipid Accumulation ◽  
Statistical Significance ◽  
The Body ◽  
P Value ◽  
Strong Positive Correlation ◽  
Lipid Accumulation Product

Background: Metabolic syndrome (MS) is defined to be cluster of metabolic interrelated risk factors of such as obesity, elevated blood pressures, glucose metabolism disturbances and dyslipidemia. "Lipid accumulation product" (LAP) – is a simple and novel index based on a combination of an anthropometric dimension and a metabolic dimension.Methods: One hundred patients with metabolic syndrome were included in study. Data was collected through a prepared proforma which included various parameters related to history, thorough clinical examination, and laboratory parameters. Further the patients were assessed for the body mass index (BMI) and lipid accumulation product (LAP). BMI and LAP then correlated with metabolic syndrome.Results: Our present study is conducted among the population meeting the IDF criteria of MS, with a mean age of 54.52±12.65years and female predominance (54%). 72% and 62% of the study group had Diabetes Mellitus and Hypertension respectively. The mean BMI in our study is 29.04±5.11 kg/m2 with 25% of the population are non-obese. The average LAP value in our present study is 111.51±59.71 cm mmol/l and shown increasing trend with increasing age. LAP had a mean value of 85.19 cm mmol/l, 118.52 cm mmol/l and 122.37 cm mmol/l in the study population satisfying 3/5, 4/5 and 5/5 criteria of Metabolic Syndrome respectively. This shows LAP (P<0.001) has better correlation with MS when compared to BMI (P<0.001) in ANOVA test. In our present study, the presence of diabetes mellitus resulted in significant elevated LAP values i.e. 85.10±31.40 cm mmol/l among non-diabetics to 121.78±64.92 cm mmol/l among diabetics, which is of statistical significance (p value 0.005).Conclusions: LAP showed strong positive correlation with metabolic syndrome and it also positively correlated with increasing number of components of metabolic syndrome. LAP found to be better predictor of MS than BMI.

scholarly journals Pattern of Tobacco Consumption among the Diabetic Patients

1970 ◽  
Vol 6 (2) ◽  
pp. 95-99
Author(s):  
MK Biswas ◽  
AK Biswas ◽  
G Biswas ◽  
J Begum
Keyword(s):  
Diabetes Mellitus ◽  
Smokeless Tobacco ◽  
Heart Diseases ◽  
Smoking Habit ◽  
Positive Association ◽  
Tobacco Consumption ◽  
Key Words Diabetes Mellitus ◽  
Diabetic Patients ◽  
Key Words Diabetes ◽  
Cross Sectional

Diabetes Mellitus (DM) is a public health challenge all over the world. Recent evidence suggests that there is a positive association between smoking and the risk of diabetes. This descriptive cross-sectional study was conducted from March to June 2008 at BIRDEM Hospital, Shahbagh, Dhaka to find out pattern of tobacco consumption among diabetic patients. Age of the respondents was >15 years. With purposive sampling total 255 respondents were selected. Data was collected through face-to-face interview with structured questionnaire. Out of 255 respondents, 51.4% consumed deferent type of tobacco. Smoker was 63.36% and smokeless tobacco user was 52.67%. The highest (45.80%) had habit of smoking, 36.64% had habit of smokeless tobacco and 17.56% had habit both types of tobacco consumption. The highest smoking and smokeless tobacco consumption found within 50-60 years age group. Total 60.80% male had smoking habit and 32.82% female were smokeless tobacco consumer but no female was smoker. Twenty nine percent tobacco consumers were primarily educated, 16.08% service holders were tobacco consumer and 13.75% service holders were smoker. Among respondents lung diseases and heart diseases were common (78.54.0% and 49.36%). Respondents who consumed tobacco were suffered (74.36%) more complication than non-tobacco consumer (25.64%). So an effective awareness program is required to discourage the consumption of tobacco to protect diabetic patients. Key words: Diabetes mellitus; Smoking; Tobacco DOI: http://dx.doi.org/10.3329/fmcj.v6i2.9210 FMCJ 2011; 6(2): 95-99

Leitliniengerechte Therapie der Adipositas

2008 ◽  
Vol 02 (02) ◽  
pp. 59-66
Author(s):  
H. Hauner
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Mass ◽  
Typ 2 Diabetes ◽  
Typ 2 Diabetes Mellitus ◽  
Chirurgische Maßnahmen ◽  
Leitliniengerechte Therapie ◽  
Strukturelle Voraussetzungen

ZusammenfassungAdipositas stellt eines der zentralen Gesundheitsprobleme dar. Der Phänotyp ist durch eine Vermehrung des Körperfetts charakterisiert, die mit einem erhöhten Morbiditätsund Mortalitätsrisiko einhergeht. Ab einem Body-Mass-Index (BMI) von 30 kg/m2 bzw. ab einem BMI von 25 kg/m2 bei gleichzeitigem Vorliegen von Begleiterkrankungen wie z. B. Typ-2-Diabetes mellitus ist daher eine gewichtssenkende Behandlung indiziert. Dafür steht ein breites Spektrum von evidenzbasierten Therapiemaßnahmen zur Verfügung, deren Einsatz auf die individuellen Bedürfnisse und Möglichkeiten des Patienten zugeschnitten werden muss. Die Primärbehandlung zielt auf eine langfristige Lebensstiländerung mit energieärmerer Kost und Steigerung der körperlichen Aktivität. Das Konzept der abgestuften Therapie beinhaltet auch sehr niedrig kalorische Diäten, gewichtssenkende Medikamente und, bei extremer therapieresistenter Adipositas, chirurgische Maßnahmen. Der Therapieerfolg hängt entscheidend von der Motivation des Patienten ab, die Eigenverantwortung für sein Gewichtsmanagement zu übernehmen. Bereits eine Senkung des Körpergewichts um fünf bis zehn Prozent führt zu einer signifikanten Besserung der Lebensqualität sowie zahlreicher Begleiterkrankungen. Eine wirksame Adipositastherapie ist im deutschen Gesundheitssystem bisher nicht möglich, da keine Kostenübernahme durch Krankenkassen stattfindet und deshalb auch viele strukturelle Voraussetzungen dafür fehlen. Daneben sind zusätzlich Aktivitäten zur Primärprävention der Adipositas auf gesamtgesellschaftlicher Ebene dringend erforderlich.

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