scholarly journals Female genital tuberculosis: A disease seen again in Europe

2007 ◽  
Vol 64 (12) ◽  
pp. 855-858 ◽  
Author(s):  
Dragica Pesut ◽  
Jelena Stojsic
Keyword(s):  
Abdominal Mass ◽  
Reproductive Organs ◽  
Medical Problem ◽  
Mycobacterium Tuberculosis Infection ◽  
Tissue Samples ◽  
Younger Women ◽  
Antituberculosis Treatment ◽  
Immunodeficiency Virus ◽  
Female Genital Tuberculosis ◽  
Female Genital

Background. Dramatic worsening of epidemiological situation with tuberculosis (TB) in the world has made extra- pulmonary tuberculosis actual again. Female genital TB is very rare, but each case still remains a serious medical problem. Case report. A 23-year-old human immunodeficiency virus (HIV) seronegative woman with two-month duration amenorrhea underwent surgery due to lower abdominal mass simulating a left ovary carcinoma, suggested by ultrasound examinations. During sampling, we found a mass of round, up to 3 mm, necrotizing nodules, diffuse in the uterus, ovarian and tubarial surfaces, in cervical and endometrial mucosa, and even in myometrium and fat omental tissue. No tumor mass was found. Microscopically, the tissue samples from all reproductive organs and omentum contained numerous tuberculous caseating granulomas. Mycobacteria were identified by Ziehl-Neelsen method. Antituberculosis treatment had been completed. Conclusion. In the differential diagnosis of an ovarian tumor and ascites TB should always be considered. It should also be suspected in recent Mycobacterium tuberculosis infection in younger women with amenorrhea, either HIV-seropositive or not.

scholarly journals The incidence detection of tuberculosis in patients with infertility and abnormal uterine bleed: a study in North Indian population

2019 ◽  
Vol 8 (8) ◽  
pp. 3041
Author(s):  
Simmanjit Kaur ◽  
Unmesh Santpur ◽  
Sunita Mor
Keyword(s):  
Female Genital Tract ◽  
Uttar Pradesh ◽  
Reproductive Age ◽  
Genital Tuberculosis ◽  
Immunodeficiency Virus ◽  
Female Genital Tuberculosis ◽  
Acute Form ◽  
Reproductive Age Group ◽  
Hiv Negative ◽  
Female Genital

Background: Tuberculosis (TB) remains a major global health problem, responsible for ill health among millions of people each year. TB ranks as the second leading cause of death from an infectious disease worldwide, after the human immunodeficiency virus (HIV). The latest estimates included in this report are that there were 9.0 million new TB cases in 2013 and 1.5 million TB deaths (1.1 million among HIV-negative people and 0.4 million among HIV-positive people). In India the incidence of genital tuberculosis is nearly about 18%. And in female genital tract it is estimated that 18% in India suffer from genital TB.Methods: The study was carried-out during November 2014 to March 2016 at Maharishi Markandeshwar deemed to be University, MMIMSR Mullana (Ambala).  A total of 100 females of reproductive age attending the Gynaecology Outpatient were finally recruited on the basis of inclusion and exclusion criteria.Results: In our study majority i.e. 39 (39.0%) patient were found in the group of 20-29 years of age followed by 38 (38.0%) patients in the group of 30-39 years of age. Only 23 (23.0%) were found in the group of 40-49 years of age. In our study majority i.e. 54 (54.0%) patients were from Haryana followed by 44 (44.0%) patients were from Uttar Pradesh and only 2 (2.0%) patients were from Punjab. Out of 100 patients majority i.e. 76 (76.0%) patients had negative TB with either of investigation and only 24 (24.0%) patients had positive TB with either of investigation.Conclusions: Female genital tuberculosis affects the females of reproductive age group. The disease manifests itself as pelvic inflammatory disease in its acute form with menstrual irregularities and later infertility, and is almost always secondary to a primary lesion elsewhere.

Effect of Antitubercular Therapy on Endometrial Function in Infertile Women with Female Genital Tuberculosis

2016 ◽  
Vol 16 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Jai Bhagwan Sharma ◽  
Jayaramaiah Sneha ◽  
Urvashi B. Singh ◽  
Sunesh Kumar ◽  
Kallol Kumar Roy ◽  
...  
Keyword(s):  
Antitubercular Therapy ◽  
Genital Tuberculosis ◽  
Infertile Women ◽  
Female Genital Tuberculosis ◽  
Female Genital

scholarly journals A Randomized Controlled Trial of Isoniazid to Prevent Mycobacterium tuberculosis Infection in Kenyan Human Immunodeficiency Virus–Exposed Uninfected Infants

2020 ◽  
Author(s):  
Sylvia M LaCourse ◽  
Barbra A Richardson ◽  
John Kinuthia ◽  
A J Warr ◽  
Elizabeth Maleche-Obimbo ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Mycobacterium Tuberculosis ◽  
High Risk ◽  
Adverse Events ◽  
Controlled Trial ◽  
Preventive Therapy ◽  
Infection Prevalence ◽  
Mycobacterium Tuberculosis Infection ◽  
Immunodeficiency Virus ◽  
Exposed Uninfected

Abstract Background Human immunodeficiency virus (HIV)–exposed uninfected (HEU) infants in endemic settings are at high risk of tuberculosis (TB). For infants, progression from primary Mycobacterium tuberculosis (Mtb) infection to TB disease can be rapid. We assessed whether isoniazid (INH) prevents primary Mtb infection. Methods We conducted a randomized nonblinded controlled trial enrolling HEU infants 6 weeks of age without known TB exposure in Kenya. Participants were randomized (1:1) to 12 months of daily INH (10 mg/kg) vs no INH. Primary endpoint was Mtb infection at end of 12 months, assessed by interferon-γ release assay (QuantiFERON-TB Gold Plus) and/or tuberculin skin test (TST, added 6 months after first participant exit). Results Between 15 August 2016 and 6 June 2018, 416 infants were screened, with 300 (72%) randomized to INH or no INH (150 per arm); 2 were excluded due to HIV infection. Among 298 randomized HEU infants, 12-month retention was 96.3% (287/298), and 88.9% (265/298) had primary outcome data. Mtb infection prevalence at 12-month follow-up was 10.6% (28/265); 7.6% (10/132) in the INH arm and 13.5% (18/133) in the no INH arm (7.0 vs 13.4 per 100 person-years; hazard ratio, 0.53 [95% confidence interval {CI}, .24–1.14]; P = .11]), and driven primarily by TST positivity (8.6% [8/93] in INH and 18.1% [17/94] in no INH; relative risk, 0.48 [95% CI, .22–1.05]; P = .07). Frequency of severe adverse events was similar between arms (INH, 14.0% [21/150] vs no INH, 10.7% [16/150]; P = .38), with no INH-related adverse events. Conclusions Further studies evaluating TB preventive therapy to prevent or delay primary Mtb infection in HEU and other high-risk infants are warranted. Clinical Trials Registration NCT02613169.

scholarly journals Urogenital Schistosomiasis—History, Pathogenesis, and Bladder Cancer

2021 ◽  
Vol 10 (2) ◽  
pp. 205
Author(s):  
Lúcio Lara Santos ◽  
Júlio Santos ◽  
Maria João Gouveia ◽  
Carina Bernardo ◽  
Carlos Lopes ◽  
...  
Keyword(s):  
Schistosoma Haematobium ◽  
Historical Perspective ◽  
Hiv Transmission ◽  
Parasite Infection ◽  
Urogenital Schistosomiasis ◽  
Host Parasite Interactions ◽  
Immunodeficiency Virus ◽  
Recent Outbreak ◽  
Host Parasite ◽  
Female Genital

Schistosomiasis is the most important helminthiasis worldwide in terms of morbidity and mortality. Most of the infections occurs in Africa, which about two thirds are caused by Schistosoma haematobium. The infection with S. haematobium is considered carcinogenic leading to squamous cell carcinoma (SCC) and urothelial carcinoma of the urinary bladder. Additionally, it is responsible for female genital schistosomiasis leading to infertility and higher risk of human immunodeficiency virus (HIV) transmission. Remarkably, a recent outbreak in Corsica (France) drew attention to its potential re-mergence in Southern Europe. Thus far, little is known related to host-parasite interactions that trigger carcinogenesis. However, recent studies have opened new avenues to understand mechanisms on how the parasite infection can lead cancer and other associated pathologies. Here, we present a historical perspective of schistosomiasis, and review the infection-associated pathologies and studies on host–parasite interactions that unveil tentative mechanisms underlying schistosomiasis-associated carcinogenesis.

Computed Tomographic Findings in Female Genital Tuberculosis Tubo-Ovarian Masses

2021 ◽  
Author(s):  
Jai Bhagwan Sharma ◽  
Smita Manchanda ◽  
Parul Jaiswal ◽  
Sona Dharmender ◽  
Urvashi Singh ◽  
...  
Keyword(s):  
Genital Tuberculosis ◽  
Computed Tomographic ◽  
Female Genital Tuberculosis ◽  
Ovarian Masses ◽  
Female Genital

scholarly journals The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient—Case Report

Pathogens ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1523
Author(s):  
Florentina Dumitrescu ◽  
Cătălina-Gabriela Pisoschi ◽  
Vlad Pădureanu ◽  
Andreea Cristina Stoian ◽  
Livia Dragonu ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Immunocompromised Patient ◽  
Symptomatic Treatment ◽  
Pneumocystis Pneumonia ◽  
Hiv Positive ◽  
Patient Case ◽  
Mycobacterium Tuberculosis Infection ◽  
Antituberculosis Therapy ◽  
Antituberculosis Treatment

Tuberculosis (TB) is an important opportunistic infection in HIV-positive people. We are reporting a case of a 31-year-old HIV-infected patient who was hospitalized in July 2021 for dyspnea, cough with mucopurulent sputum and asthenia. He was confirmed to have Serratia liquefaciens pneumonia and acute respiratory failure. The evolution was unfavorable despite the antibiotic, pathogenic and symptomatic treatment. Because the patient had severe immunosuppression (CD4 count = 37 cell/mm3), we used QuantiFERON-TB Gold Plus for the detection of the Mycobacterium tuberculosis infection. The antituberculosis therapy was initiated, which resulted in a significant improvement of the general condition and the patient was discharged with the recommendation to continue antiretroviral therapy, antituberculosis treatment and Trimethoprim/Sulfamethoxazole—single tablet daily for the prophylaxis of Pneumocystis pneumonia.

scholarly journals Retrospective Evaluation of Pediatric Patients With Abdominal Tuberculosis: A Single Center Experience

2020 ◽  
Vol 54 (4) ◽  
pp. 204-211
Author(s):  
Sevgi Yaşar Durmuş ◽  
Gönül Tanır ◽  
Ayşe Seçil Ekşioğlu ◽  
Türkan Aydın Teke ◽  
Yasemin Taşçı Yıldız ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Extrapulmonary Tuberculosis ◽  
Abdominal Tuberculosis ◽  
Diagnostic Methods ◽  
Mycobacterium Tuberculosis Infection ◽  
Reactive Protein ◽  
Single Center Experience ◽  
Antituberculosis Treatment ◽  
History Of ◽  
The Mean

Objective: Abdominal tuberculosis is a kind of extrapulmonary tuberculosis that can usually occur during the lymphohematogenous spread of first Mycobacterium tuberculosis infection, develop by neighborhood from an abdominal focus or a mesenteric lymph node. The aim of this study is to evaluate pediatric cases diagnosed with abdominal tuberculosis. Material and Methods: Between 2012-2018, seven patients diagnosed with abdominal tuberculosis through patients who diagnosed with extrapulmonary tuberculosis in our hospital, were included in study. Demographic and clinical characteristics, diagnostic methods, commenced treatments and clinical follow up of patients were listed from medical records. Results: Of patients, four were female. The mean age was 144.2 ± 42.7 months. None of the patients had a history of tuberculosis contact. The median complaint time was 20 days (5-180). The most frequent complaint was abdominal pain and the most frequent physical examination finding was abdominal tenderness. Mean white blood cell count was 9.26 x 103 ± 4.77 x 103 μ/L, C reactive protein level: 79.9 ± 54.9 mg/dL, erytrocyte sedimentation rate: 45 ± 30 mm/h. Tuberculin skin test was positive in two patients, interferon gamma releasing assay was positive in three patients, and in two patients, both tests were positive. There were findings suggesting tuberculosis on pulmonary imaging in five patients and abdominal imaging in all patients. Histopathological examination of the specimens of six patients revealed findings consistent with tuberculosis. The presence of M. tuberculosis was confirmed microbiologically in clinical specimens taken from three patients. The most common abdominal tuberculosis type was mesenteric lymphadenitis. The mean time from admission to diagnosis was 15 ± 12.8 days. All patients recieved antituberculosis treatment. Conclusion: Abdominal tuberculosis should be kept in mind, in patients presenting with abdominal complaints lasting more than five days. Ultrasonography and computed tomography are useful to determine abdominal tuberculosis type. The disease can be sucsessfully treated with standart antituberculosis treatment.

scholarly journals Female genital tuberculosis: Five case reports

2021 ◽  
Vol 10 (1) ◽  
pp. 41
Author(s):  
Abdurrahman Kaya ◽  
SibelYildiz Kaya ◽  
Esra Zerdali ◽  
Ali Can
Keyword(s):  
Case Reports ◽  
Genital Tuberculosis ◽  
Female Genital Tuberculosis ◽  
Female Genital
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