scholarly journals Comparison of two therapeutic protocols in patients with antiphospholipid antibodies and recurrent miscariages

2005 ◽  
Vol 62 (6) ◽  
pp. 435-439 ◽  
Author(s):  
Katarina Jeremic ◽  
Miroslava Pervulov ◽  
Miroslava Gojnic ◽  
Jelena Dukanac ◽  
Aleksandar Ljubic ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Pregnancy Outcomes ◽  
Antiphospholipid Antibodies ◽  
Statistical Tests ◽  
Statistical Significance ◽  
Anticardiolipin Antibodies ◽  
Heparin Group ◽  
Significant Difference ◽  
Therapeutic Protocols ◽  
In Pregnancy

Aim. To compare the effects of two therapeutic protocols for the patients with recurrent miscarriages associated with the presence of antiphospholipid (anticardiolipin) antibodies. Methods. A prospective observational study included 20 patients with antiphospholipid antibodies in the first group who received low-molecular heparin and aspirin. The second group of 20 patients, in addition to this therapy, received immunotherapy (intravenous immunoglobulin). Aspirin was administered at the time of a positive pregnancy test, and low molecular heparin not before the fetal heart activity registration by ultrasound. Intravenous immunoglobulin was given prior to the conception or at the beginning of the pregnancy. We compared these groups according to the pregnancy outcomes and the occurrence of complications during pregnancy, using standard statistical tests. Results. The rate of positive gestational outcome in the patients treated with aspirin and low-molecular heparin was 85% (17/20), and in the second group it was 90% (18/20). There was no significant difference in pregnancy outcomes between these groups (p > 0.05), except for the occurrence of preeclampsia and thrombocytopenia, which were recorded only in the aspirin and low-molecular heparin group, but with no statistical significance (p > 0.05) compared to the second group, which received immunoglobulin additionally. Conclusion. There was no significant difference (p > 0.05) in pregnancy outcomes between the two studied therapeutic protocols, but the therapy with aspirin and low-molecular heparin was cheaper and easier to apply than the therapy with immunoglobulins. The results of our study confirmed that the final pathogenic mechanisms in recurrent fetal miscarriages were inflammation and thrombosis of the uteroplacental blood vessels.

scholarly journals CircaCompare: a method to estimate and statistically support differences in mesor, amplitude and phase, between circadian rhythms

2019 ◽  
Author(s):  
Rex Parsons ◽  
Richard Parsons ◽  
Nicholas Garner ◽  
Henrik Oster ◽  
Oliver Rawashdeh
Keyword(s):  
Wave Function ◽  
Statistical Tests ◽  
Statistical Significance ◽  
P Value ◽  
Cross Sectional ◽  
Fundamental Interest ◽  
Response Variable ◽  
Highly Sensitive ◽  
Significant Difference ◽  
Phase Amplitude

Abstract Motivation A fundamental interest in chronobiology is to compare patterns between groups of rhythmic data. However, many existing methods are ill-equipped to derive statements concerning the statistical significance of differences between rhythms that may be visually apparent. This is attributed to both the form of data used (longitudinal versus cross-sectional) and the limitations of the statistical tests used to draw conclusions. Results To address this problem, we propose that a cosinusoidal curve with a particular parametrization be used to model and compare data of two sets of observations collected over a 24-h period. The novelty of our test is in the parametrization, which allows the explicit estimation of rhythmic parameters [mesor (the rhythm-adjusted mean level of a response variable around which a wave function oscillates), amplitude and phase], and simultaneously testing for statistical significance in all three parameters between two or more groups of datasets. A statistically significant difference between two groups, regarding each of these rhythmic parameters, is indicated by a P-value. The method is evaluated by applying the model to publicly available datasets, and is further exemplified by comparison to the currently recommended method, DODR. The results suggest that the method proposed may be highly sensitive to detect rhythmic differences between groups in phase, amplitude and mesor. Availability and implementation https://github.com/RWParsons/circacompare/

scholarly journals Who indicates Caesarean section in Romania? A cross-sectional survey in tertiary level maternity on childbirth patients and doctors' profiles 

2020 ◽  
Author(s):  
Anca Angela Simionescu ◽  
Alexandra Horobet ◽  
Erika Marin ◽  
Lucian Belascu
Keyword(s):  
Statistical Tests ◽  
Statistical Significance ◽  
Tertiary Level ◽  
The European Union ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Significant Difference ◽  
Mode Of Birth ◽  
High Income Category ◽  
Women’S Preferences

Abstract Background. Cesarean section (C-section) rate in Romania is the second-highest in the European Union (44.1% in 2017), and the number of C-sections performed in the country has increased in the past decades. Given how common C-section is now, it is important to gain insight into the practice and perceptions of patients and doctors in countries with high C-section rates. The objectives are 1) to compare the preferred modes of birth among women; 2) to draw a profile of patients and doctors in whose case the actual birth method is different from the preferred method; and 3) to analyze the way Romanian women want to give birth. Methods. We conduct a statistical analysis based on an observational, analytical, and cross-sectional survey on 117 singleton pregnant women more than 36 weeks in spontaneous labor in tertiary level maternity in Romania. Various statistical tests have been used to indicate statistical significance. Results. We calculate an increase of almost 58% in actual childbirth mode against preferred childbirth by C-sections, rather difficult to justify based only on medical emergencies. There are 22 patients with non-concordant C-section indications between preferred and actual mode of birth, 7 of them (31.8%) preferred natural birth and 15 (68.2%) preferred C-section. The profiles of patients with concordant and non-concordant delivery modes are different and indicate a statistically significant difference between the preference for delivery and actual birth method. Patients who preferred vaginal birth, but gave birth by C-section, are mature and more educated women, in the middle to high-income category, mostly attended by consultant doctors and specialists. Doctors’ profiles show that specialists and consultants attend the largest share of non-concordant births, while residents and young senior doctors attend mostly vaginal births. Conclusions. We emphasize health system particularities in Romania as triggers of high C-section rates that favor women’s preferences against C-section medical indication. Improving patients’ confidence in the health care system, built on competence and fitted hierarchical team position may lead to choosing the optimal way of birth for childbirth safety and pain control.

Who Indicates Caesarean Section in Romania? A Cross-Sectional Survey in Tertiary Level Maternity on Childbirth Patients and Doctors' Profiles

2020 ◽  
Author(s):  
Anca Angela Simionescu ◽  
Alexandra Horobet ◽  
Erika Marin ◽  
Lucian Belascu
Keyword(s):  
Health System ◽  
Statistical Tests ◽  
Statistical Significance ◽  
Tertiary Level ◽  
Delivery Mode ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Medical Indication ◽  
Delivery Modes ◽  
Significant Difference

Abstract Background. C-section rate in Romania is the second-highest in the European Union (44.1% in 2017) and the number of C-sections performed in the country increased by 32.1% between 2009 and 2017. We offer for the first time insights into the practice and perceptions of patients and doctors in Romania towards delivery mode and on health system particularities that lead to increased numbers of C-sections. The objectives are 1) to compare the preferred modes of birth among women 2) to draw a profile of patients in whose case the actual birth method is different from the preferred method, and 3) to outline a profile of doctors and patients based on the modes of delivery. Methods. We conduct a statistical analysis based on an observational, analytical, and cross-sectional survey on 117 singleton pregnant women more than 36 weeks in spontaneous labor in tertiary level maternity in Romania. Various statistical tests have been used to indicate statistical significance. Results. Our results show an increase of almost 58% in actual childbirth mode against preferred childbirth by C-sections, rather difficult to justify based only on medical emergencies. There are 22 patients with non-concordant C-section indications between preferred and actual mode of birth, 7 of them (31.8%) preferred natural birth and 15 (68.2%) preferred C-section. Scarred uterus is the most frequent medical indication for C-section (30.7%). Overall, birth and birth pain assessment correlates to preferred and actual delivery modes, but respondents distinguish clearly between birth pain alone and their overall birth experience. The profiles of patients with concordant and non-concordant delivery modes are different, and indicate a statistically significant difference between the preference for delivery and actual birth method. Patients who preferred vaginal birth, but gave birth by C-section, are mature and more educated women, in the middle to the high-income category, mostly attended by consultant doctors and specialists. Doctors’ profiles show that specialists and consultants attend the largest share of non-concordant births, while residents and young senior doctors attend mostly vaginal births. Conclusions. We emphasize health system particularities in Romania as triggers of high C-section rates that favor womens’ preferences against C-section medical indication.

The Risk of Thrombosis in Patients with Lupus Anticoagulants Is Predicted by their Specific Coagulation Profile

1999 ◽  
Vol 81 (05) ◽  
pp. 695-700 ◽  
Author(s):  
Guido Finazzi ◽  
Francesca Norbis ◽  
Stefana Marziali ◽  
Roberto Marchioli ◽  
Tiziano Barbui ◽  
...  
Keyword(s):  
Antiphospholipid Antibodies ◽  
Odds Ratio ◽  
Statistical Significance ◽  
Thrombotic Event ◽  
Anticardiolipin Antibodies ◽  
The Other ◽  
Historical Cohort ◽  
Lupus Anticoagulants ◽  
Coagulation Profile

SummaryLupus anticoagulants belong to the family of antiphospholipid antibodies. They include two phospholipid-dependent inhibitors of coagulation that may be distinguished on the basis of specific coagulation profiles generated from the comparison of the ratios of the Kaolin Clotting Time (KCT) and the dilute Russell’s Viper Venom Time (dRVVT): when the ratio of the KCT exceeds that of the dRVVT, the plasma is allocated to the “KCT” coagulation profile, when the opposite occurs, the plasma is defined to belong to the “dRVVT” coagulation profile group. We prospectively followed-up a historical cohort of 100 consecutive patients with lupus anticoagulants referred to our Institution between January 1988 and October 1997 to investigate the relationship between their coagulation profile at diagnosis and the development of thrombosis during a median follow-up time of 37.5 months (range 1-115 months). Fifty-six patients were allocated to the “dRVVT” coagulation profile, whereas the other 44 displayed the “KCT” profile. Lupus anticoagulants were transient in 17 patients, without differences between the two groups. None of these patients developed clinical events before disappearance of the phospholipid-dependent inhibitors of coagulation. The 83 cases with persistent lupus anticoagulants consistently displayed the same coagulation profile they had been allocated to at entry. Fourteen patients developed 18 thromboembolic events during the follow-up, with an overall rate of thrombosis of 4.2% patients-year. Twelve of them belonged to the “dRVVT” coagulation profile, whereas the other 2 to the “KCT” profile (p = 0.03). The “dRVVT” coagulation profile gave an odds ratio of thrombosis of 5.25 (95% confidence interval [C.I.]: 1.17-23.50). Ten of the 14 patients who developed thrombosis during follow-up had already experienced thrombosis: a previous thrombotic event caused an odds ratio of recurrency of 2.72 (95% C.I.: 0.85-8.73) (p = 0.09). By multivariate analysis, the “dRVVT” coagulation profile was still associated with a trend to a higher risk of thrombosis, but the difference did not reach statistical significance. Increased levels of anticardiolipin antibodies (> 40 GPL and/or MPL units) were found in all the 14 patients (p = 0.0064). The “KCT” coagulation profile was significantly associated (p = 0.005) with moderate thrombocytopenia (platelets 50-150 × 109/l). Neither profile was found to represent a risk factor for the development of recurrent miscarriages, neoplastic diseases and death. In conclusion, the “dRVVT” profile appears to have predictive value with respect to the thrombotic complications suffered by patients with antiphospholipid antibodies.

The Association Between Antiphospholipid Antibodies and Adverse Pregnancy Outcomes: A Metaanalysis.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 1819-1819
Author(s):  
Karim Abou-Nassar ◽  
Marc Carrier ◽  
Marc Rodger
Keyword(s):  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Antiphospholipid Antibodies ◽  
Lupus Anticoagulant ◽  
Placental Abruption ◽  
Fetal Loss ◽  
Anticardiolipin Antibodies ◽  
Adverse Pregnancy Outcomes ◽  
Clinical Criteria ◽  
Adverse Pregnancy

Abstract BACKGROUND: The Sapporo criteria for the diagnosis of the antiphospholipid syndrome (APS) are based on the presence of antiphospholipid antibodies (APLA) and clinical criteria. Although pre-eclampsia, intra-uterine growth restriction (IUGR), late fetal loss and placental abruption, collectively termed “placenta mediated complications”, are recognized as clinical criteria for the APS, their association with APLA remains controversial. OBJECTIVE: This review was conducted to evaluate the association between APLA (anticardiolipin antibodies, lupus anticoagulant, anti B2 glycoprotein 1 antibodies) and placenta mediated complications in untreated women without autoimmune diseases. METHODS: We performed a systematic review of published case-control, cohort and cross sectional studies using MEDLINE (1975 to October week 2 2007), EMBASE 16 (1980 to 2007 week 42) and all EBM Reviews (3rd quarter of 2007). For eligible studies, the rates of adverse pregnancy outcomes were compared between patients with and without specific APLA. Pooled odds ratios with 95% CI were generated using random-effects models. RESULTS: Our search strategy identified 1204 potentially relevant studies. Twenty five were included in the final analysis. Results are outlined in table 1. CONCLUSION: The association between various APLA and pregnancy complications is for the most part weak and inconsistent. There is currently insufficient data to support a significant link between anti-B2 glycoprotein 1 antibodies and pregnancy morbidity. Caution should be used when establishing a diagnosis of APS based on the presence of any APLA, particularly anti-B2 glycoprotein 1 antibodies, in the setting of late pregnancy complications. Table 1 Association Between APLA and Adverse Pregnancy Outcomes Pre-eclampsia OR (95%CI) # studies / participants IUGR OR (95%CI) # studies / participants Placental abruption OR (95%CI) # studies / participants Late fetal loss OR (95%CI) # studies / participants LA: Lupus anticoagulant; aCL: Anticardiolipin antibodies; Anti-B2 GP1 antibodies: Anti-B2 glycoprotein 1 antibodies italic characters indicate statistically significant associations LA 2.88 (1.42, 5.87)
 11 / 6085 3.51 (1.38, 8.93)
 4 / 3232 0.78 (0.13, 4.80)
 2 / 226 3.56 (0.12, 106.05)
 3 / 3870 aCL (IgG/IgM) 1.71 (1.09, 2.70)
 21 / 9722 2.31 (0.74, 7.17)
 6 / 5753 1.35 (0.45, 4.02)
 4 / 1274 3.86 (1.14, 13.07)
 7 / 5963 aCL IgG 1.65 (0.84, 3.22)
 15 / 3627 6.16 (2.50, 15.18)
 2 / 1006 1.87 (0.21, 16.83)
 2 / 500 10.06 (0.88, 114.96)
 2 / 1006 aCL IgM 1.36 (0.93, 1.97)
 13 / 5397 0.75 (0.19, 2.93)
 2 / 3002 0.96 (0.24, 3.85)
 2 / 500 1.37 (0.42, 4.46)
 3 / 3212 anti- B2GP1 (IgG/IgM) 2.97 (0.47, 18.69)
 4 / 2225 20.03 (4.59, 87.43)
 1 / 1108 2.64 (0.14, 50.63)
 1 / 510 6.74 (0.24, 191.23)
 3 / 1828 anti- B2GP1 IgG 0.87 (0.38, 2.01)
 2 / 607 N/A
 0 / 0 N/A
 0 / 0 0.52 (0.02, 11.02)
 1 / 212 anti- B2GP1 IgM 0.37 (0.16, 0.85)
 1 / 400 N/A
 0 / 0 N/A
 0 / 0 1.32 (0.24, 7.42)
 1 / 210

scholarly journals Obstetric outcome in pregnancy with thrombophilia: a comparative study of two different thromboprophylaxis regimes

2017 ◽  
Vol 6 (9) ◽  
pp. 3882
Author(s):  
Shilpa Asthana ◽  
Bandana Sodhi ◽  
Satish Kumar
Keyword(s):  
Adverse Effects ◽  
Unfractionated Heparin ◽  
Pregnancy Outcomes ◽  
Low Dose ◽  
Mode Of Delivery ◽  
Obstetric Outcome ◽  
Once Daily ◽  
Group I ◽  
Significant Difference ◽  
In Pregnancy

Background: Thrombophilia in pregnancy is a leading cause of both maternal and fetal mortality and morbidity. Thromboprophylaxis is administered to the patients with thrombophilia with an aim to improve the obstetric outcome. Although various studies have proven the benefits of treating pregnant women with thrombophilia, few studies comparing the usage of Unfractionated Heparin (UFH) and Low Molecular Weight Heparin (LMWH) along with low - dose ecosprin in terms of obstetric outcome, incidence of IUGR, pre-eclampsia, mode of delivery, neonatal birth weight and adverse effects of therapy have been published. This study was undertaken to compare two different treatment modalities using either UFH or LMWH (along with low dose ecosprin) in pregnant patients with thrombophilia with respect to obstetric outcomes and incidence of adverse effects of therapy.Methods: This randomised, prospective study was conducted in patients with a previous history of recurrent pregnancy losses or previous adverse pregnancy outcomes. Sixty patients diagnosed with thrombophilia were randomly divided into two groups of 30 patients each (Group I and II). Patients in Group I received Inj Unfractionated Heparin 5000 I.U. (s.c) twice daily and Tab Ecosprin 75 mg once daily and those in Group II received Inj LMWH (enoxaparin) 40 mg (s.c) once daily and Tab Ecosprin 75 mg once daily. These pregnancies were followed and the obstetrical outcome was determined. The data collected was analysed using the Student’s `t`test and Chi-square test. P values < 0.05 were considered statistically significant.Results: There was no significant difference observed between two treatment groups with respect to pregnancy outcomes, incidence of IUGR, pre-eclampsia and mode of delivery (vaginal or by caesarean section). Treatment with a combination of LMWH and ecosprin administered to patients in Group II resulted in significantly higher neonatal birth weights.Conclusions: Treatment with a combination of LMWH and ecosprin resulted in significantly higher neonatal birth weights as compared to a regime that comprised of UFH and ecosprin. There was no significant difference seen in patients who were treated with either UFH or LMWH along with low dose ecosprin in terms of obstetric outcome, incidence of IUGR, pre-eclampsia and mode of delivery. No thromboembolic events or side effects were witnessed in patients subjected to either of the two regimes using LMWH or UFH with low dose ecosprin, thus, highlighting the safety of the antithrombotic therapy during pregnancy as used in this study.

Lack of Association Between Antiphospholipid Antibodies and Migraine

1993 ◽  
Vol 69 (05) ◽  
pp. 415-417 ◽  
Author(s):  
D A Tsakiris ◽  
L Kappos ◽  
G Reber ◽  
G A Marbet ◽  
J Le Floch-Rohr ◽  
...  
Keyword(s):  
Back Pain ◽  
Antiphospholipid Antibodies ◽  
Lupus Anticoagulant ◽  
Antithrombin Iii ◽  
Anticardiolipin Antibodies ◽  
Control Group ◽  
Group I ◽  
Significant Difference ◽  
Migrainous Infarction ◽  
Complicated Migraine

SummaryWe prospectively studied the prevalence of lupus anticoagulant, anticardiolipin antibodies (aCL) and various haemostatic parameters in 71 patients with migraine and compared the results with a control group of 32 subjects with back pain never having experienced migraine. The patients with migraine were divided into two groups: group I with migraine without (n = 18) and with aura lasting less than 60 min (n = 24) and group II with migraine with prolonged aura or migrainous infarction (complicated migraine, n = 29). The following results were obtained: a) no difference in aCL positivity was noted between migrainous patients and controls and between common migraine and complicated migraine patients and b) no statistically significant difference in haemostatic parameters (except for thrombin-antithrombin III complexes) was found between the two groups of migraine and between aCL positive and negative migrainous patients. These data suggest that anticardiolipin antibodies are not involved in the pathogenesis of migraine complications.

scholarly journals Clinical Evaluation of Time Efficiency and Fit Accuracy of Lithium Disilicate Single Crowns between Conventional and Digital Impression

Materials ◽  
2020 ◽  
Vol 13 (23) ◽  
pp. 5467
Author(s):  
Ji-Su Park ◽  
Young-Jun Lim ◽  
Bongju Kim ◽  
Myung-Joo Kim ◽  
Ho-Beom Kwon
Keyword(s):  
Conventional Method ◽  
Statistical Tests ◽  
Statistical Significance ◽  
Lithium Disilicate ◽  
Digital Impression ◽  
Time Efficiency ◽  
Digital Dentistry ◽  
Single Crown ◽  
Significant Difference ◽  
Single Crowns

The purpose of this study was to demonstrate the time-efficiency and the clinical effectiveness of chairside-fabricated lithium disilicate single crowns by digital impressions compared to the conventional method. Thirteen patients requiring a single crown on the maxillary or mandibular premolar or first molar were assigned as study subjects. The impressions were obtained using the conventional method and two digital methods with intraoral scanners: AEGIS.PO (Digital Dentistry Solution, Seoul, Korea) and CEREC Omnicam (Sirona, Bensheim, Germany). Two types of lithium disilicate single crowns were obtained; a reference crown (by conventional workflow) and a chairside crown (by digital workflow). The total time taken for fabricating the chairside crown was recorded. The replica technique was performed to compare the marginal and internal fit of the two types of crowns. In addition, accuracy of the intraoral scanners was evaluated by the best-fit alignment method. The difference between the groups was analyzed using the two-tailed paired t-test or one-way ANOVA, followed by the Student–Newman–Keuls test for multiple comparisons. Statistical significance was accepted at p < 0.05 for all statistical tests. The time required to obtain the impressions by the AEGIS (7:16 ± 1:50 min:s) and CEREC (7:29 ± 2:03 min:s) intraoral scans was significantly lower than the conventional method (12:41 ± 1:16 min:s; p < 0.001). There was no significant difference between the intraoral scanners. The total working time to fabricate the chairside crown averaged 30:58 ± 4:40 min:s. The average marginal gap was not significantly different between the reference (107.86 ± 42.45 µm) and chairside (115.52 ± 38.22 µm) crowns (p > 0.05), based on results of replica measurement. The average internal gaps were not significantly different. The average value of the root mean square between the AEGIS (31.7 ± 12.3 µm) and CEREC (32.4 ± 9.7 µm) scans was not significantly different (p > 0.05). Intraoral scans required a significantly shorter impression time than the conventional method, and it was possible to fabricate a lithium disilicate crown in a single visit. There were no statistically significant differences in the fit of the restorations and accuracy of the intraoral scanners compared to the conventional workflow.

scholarly journals Placental malarial parasitaemia and pregnancy outcome among parturients in a tertiary hospital in South- South Nigeria

2015 ◽  
Vol 6 (6) ◽  
pp. 53-59
Author(s):  
Godwin J Ibanga ◽  
Aniekan M Abasiattai ◽  
Emem A Bassey ◽  
Michael Ukpe ◽  
Olujimi A Olatunbosun ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnancy Outcomes ◽  
Statistical Significance ◽  
Placental Malaria ◽  
Malaria In Pregnancy ◽  
Sub Saharan Africa ◽  
Cross Sectional ◽  
Adverse Pregnancy ◽  
In Pregnancy

Background: Malaria is the most common human parasitic disease and continues to be a complex and overwhelming global health problem, especially in sub-Saharan Africa. Placental malaria, one of the major features of malaria in pregnancy has been associated with serious adverse health consequences to both the mother and her fetus. Objective: This study sought to determine the prevalence of maternal, cord, and placental malarial parasitaemia at parturition, the association between maternal and placental parasitaemia, and also the association between placental parasitaemia and pregnancy outcomes. Materials and Methods: A descriptive cross-sectional design was used to study 330 pregnant women selected by the systematic random sampling technique as they presented in the labour ward of University of Uyo Teaching Hospital, Uyo between April, 2012 and September, 2012. Pre-delivery, maternal peripheral blood was taken for malaria parasite (MP) and packed cell volume (PCV). Post delivery, cord blood was taken for MP and PCV estimation while placental blood was examined for MP. Neonatal demographic and clinical characteristics were also obtained. The data was analyzed using SPSS version 17. Level of statistical significance was set at P less than 0.05 (P < 0.05). Results: The mean age of the respondents was 28.8 ± 4.4 years. The prevalence of maternal, cord, and placental parasitaemia were 30.3%, 14.8% and 18.2% respectively. There was a strong correlation between maternal parasitaemia and placental parasitaemia (rho = 0.75, P< 0.001). Also, a significant linear association between cord parasitaemia and placental malaria (rho = 0.87, p< 0.001) was found. Placental malaria predisposed to low birth weight (OR 1.01{95%CI 1.001 – 1.02}, p = 0.04) and fetal anaemia (OR 1.02{95%CI 1.01 – 1.03}, p < 0.001. Conclusion: There is a relatively high prevalence of placental parasitaemia at parturition. Placental malaria is associated with adverse pregnancy outcomes such as low birth weight, fetal anaemia and cord parasitaemia. Proven strategies to prevent malaria in pregnancy such as use of ITNs and IPT and free antenatal care should be intensified to curb this deadly but preventable disease.DOI: http://dx.doi.org/10.3126/ajms.v6i6.12401Asian Journal of Medical Sciences Vol.6(6) 2015 53-59

scholarly journals Studying the Role of IFN-γ, Vitamin C, SOD, LH, FSH, APA and ACA in Toxoplasma gondii Infected Miscarriage Women

2019 ◽  
Vol 16 (3(Suppl.)) ◽  
pp. 0697
Author(s):  
Ismael Et al.
Keyword(s):  
Vitamin C ◽  
Pregnant Women ◽  
Antiphospholipid Antibodies ◽  
Acute Infection ◽  
Blood Parameters ◽  
Anticardiolipin Antibodies ◽  
Super Oxide Dismutase ◽  
Significant Difference ◽  
Ifn Γ ◽  
Igg Level

This study is designed to detect the level of cytokine IFN-γ concentration, and some antioxidants, including super oxide dismutase (SOD) and Vitamin C, and to estimate the level of sex hormones (FSH and LH), and to determine auto-antibodies (antiphospholipid antibodies (APA) IgG\IgM, and anticardiolipin antibodies (ACA) IgG\IgM) and to estimate the blood parameters in 51 miscarriage women infected with T.gondii distributed depending on the type of antibodies. Additionally, 39 volunteers non-infected with T.gondii included (19 miscarriage women, 10 pregnant women and 10 non-pregnant women). ELISA and spectrophotometer method were used in this study. The results of IFN-γ showed a significant increase)p<0.05) in the level of IFN-γ  in women infected with T.gondii compared with volunteer groups. The current study shows a significant difference in the level of hormones, where the concentration of LH hormone increased in married non-pregnant women compared with other groups, while the concentration of FSH hormone increased in toxoplasmosis women compared with volunteer groups. The results of antioxidants showed no significant difference in Vitamin C activity in infected women compared with volunteer groups, while super oxide dismutase (SOD) activity was significantly lower in infected women compared with volunteer groups. The results of autoantibodies showed a significant difference in anticardiolipin antibodies (ACA) IgM level, the highest level was in aborted women infected with acute infection (IgM Ab), while the anticardiolipin antibodies (ACA) IgG level recorded the highest level in aborted women infected with both acute and chronic infection (IgG&IgM)). The results showed no significant difference in antiphospholipid antibodies (APA) IgM level in infected women when compared to the volunteer groups, while the results showed significant difference in antiphospholipid antibodies (APA) IgG level, where the highest concentration was in the volunteer groups (pregnant and non-pregnant married women). The results of blood parameters showed significant differences in differential leucocytes except for Basophils and Monocytes, and the results showed significant differences in differential erythrocytes, HB, PLT, and PCV.

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