scholarly journals Giant destructive sinonasal polyposis

2015 ◽  
Vol 143 (3-4) ◽  
pp. 186-189 ◽  
Author(s):  
Milovan Dimitrijevic ◽  
Nenad Arsovic ◽  
Zoran Dudvarski ◽  
Ivan Boricic
Keyword(s):  
Nasal Polyps ◽  
Soft Tissue Tumor ◽  
Squamous Metaplasia ◽  
Polypoid Mass ◽  
Polypoid Growth ◽  
Nasal Cavities ◽  
Fungal Hyphae ◽  
Frontal Sinuses ◽  
Sinonasal Polyposis ◽  
Maxillary Sinuses

Introduction. Authors report their clinical experience in managing a 46-year-old male patient with long lasting nose breathing difficulties caused by nasal obstruction due to a large bilateral tumor masses in both nasal cavities. Case Outline. Physical examination, laboratory and biochemistry analyses, as well as computed tomography showed an inhomogeneous soft-tissue tumor mass completely filling both nasal cavities, maxillary, ethmoidal, sphenoidal, and frontal sinuses on both sides, accompanied by destruction of bony walls of all sinuses. Preoperative histopathology analysis showed a polyp with squamous metaplasia. The gigantic polypoid mass was removed by bicoronal approach to the frontal and ethmoidal sinuses and by direct approach to the maxillary sinuses and nasal cavity. Definite histopathology analysis confirmed the initial diagnosis, but the presence of fungal hyphae in allergic mucus was also observed. Conclusion. Polypoid growth in the nose rarely grow to such gigantic dimensions that it causes destruction of all walls of paranasal sinuses. Considering so far published reports from the literature, the presented case is among the biggest nasal polyps reported until now.

scholarly journals Subcutaneous Zygomycosis Due to Basidiobolus ranarum: A Case Report from Maharastra, India

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Mani Anand ◽  
Sanjay D. Deshmukh ◽  
Dilip P. Pande ◽  
Suresh Naik ◽  
Dhyaneshwari P. Ghadage
Keyword(s):  
Case Report ◽  
Soft Tissue Tumor ◽  
Histopathological Examination ◽  
Inflammatory Lesion ◽  
Complete Recovery ◽  
Rare Entity ◽  
Complete Excision ◽  
Fungal Hyphae ◽  
Microbiological Examination ◽  
Asian Child

Entomophthoromycosis is a rare entity. We hereby report a case of entomophthoromycosis in a three-year-old Asian child who presented with a painless, nontender, rapidly increasing large swelling on the thigh of six months duration, which was initially misdiagnosed as a soft tissue tumor and resected. The cause of misleading diagnosis was rapid growth of the lesion in a short duration of time, indicating the possibility of a tumor. Histopathological examination revealed an inflammatory lesion with aseptate fungal hyphae and the characteristic Splendore-Hoeppli phenomenon. Microbiological examination identified the fungus as Basidiobolus ranarum. Complete excision of the lesion followed by antifungal therapy was associated with complete recovery. Entomophthoromycosis should be considered early when children from endemic areas present with unusual, rapid-growing lesions of the subcutaneous region. In order to emphasize tumor-like presentation of zygomycosis, we are presenting this case.

scholarly journals The technique of dermoplasty to treat recurrent nasal polyps: preoperative evaluation, surgical details, postoperative endoscopic appearance and histopathologic analysis

2016 ◽  
Vol 6 (24) ◽  
pp. 203-206
Author(s):  
George Anastasopoulos ◽  
Dilyana Vicheva ◽  
Eleni-Christina Tsiompanou ◽  
Eleftherios Ferekidis
Keyword(s):  
Nasal Polyps ◽  
Preoperative Evaluation ◽  
Squamous Metaplasia ◽  
Morbidity Rate ◽  
Split Thickness Skin Graft ◽  
Nasal Breathing ◽  
Effective Measure ◽  
Short Course ◽  
Histopathologic Analysis ◽  
A Minor

Abstract BACKGROUND. The tendency of the nasal polyps for recurrence is well established and recognized. A potentially effective measure to reduce this tendency seems to be the replacement of the mucosa responsible for polyp growth. MATERIAL AND METHODS. Since February 2012, we have used this method in fifteen patients with intractable polyposis. After a short course of preoperative medication, we performed a detailed computed scan analysis to study the anatomy of the ethmoidal complex and calculate the area and contour of the graft. Under general anaesthesia, we removed the mucosa of the nasal roof and replaced it with a split-thickness skin graft. For maintenance, only a short course of nasal drops every three months seems to suffice. RESULTS. Excluding the first two cases due to a poor surgical technique, the rest of the cases may be considered successful. All patients experience a functional nose with restored nasal breathing and occasionally olfactory function with only a minimal pharmaceutical aid. Polyps still grow, but they show a much more benign course and are readily responsive to medical treatment. Interestingly, polyps present squamous metaplasia postoperatively. This feature needs further investigation. CONCLUSION. The method of dermoplasty presents a high potential for control of polyp growth. With only an hour prolongation of surgical time, a minor increase in complication rate and a small increase in morbidity rate, the technique deserves further attention from the rhinological society.

scholarly journals Nasal Polyposis and Fungal Schizophyllum Commune Infection: A Case Report

2011 ◽  
Vol 54 (2) ◽  
pp. 83-86 ◽  
Author(s):  
Aleksandar Perić ◽  
Danilo Vojvodić ◽  
Lidija Zolotarevski ◽  
Aneta Perić
Keyword(s):  
Rare Case ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Histopathological Examination ◽  
Schizophyllum Commune ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis ◽  
Fungal Hyphae ◽  
Oral Itraconazole ◽  
Basidiomycete Fungus

We present a rare case of eosinophilic fungal rhinosinusitis with nasal polyps in a 32-year-old woman caused by basidiomycete fungusSchizophyllum commune. Diagnosis was done by the endoscopic nasal examination, computed tomography (CT) of the paranasal sinuses, the histopathological examination of polyps, the presence of eosinophils and fungal hyphae in nasal mucus and by the detection ofS. communeby culture. The patient was successfully treated by combination of oral itraconazole and topical corticosteroid therapy combined with surgery. The pathogenesis and diagnosis of allergic fungal rhinosinusitis are also discussed.

Design of Nasal Ultrasound

2014 ◽  
Vol 3 (1) ◽  
pp. 63-72
Author(s):  
Uma Arun ◽  
M.K. Namitha ◽  
Ashwini Venugopal ◽  
Anima Sharma
Keyword(s):  
Paranasal Sinuses ◽  
The Body ◽  
Ultrasound Technique ◽  
One Dimensional ◽  
X Ray ◽  
Paranasal Sinusitis ◽  
Area Of Interest ◽  
Ultrasound System ◽  
Frontal Sinuses ◽  
Maxillary Sinuses

An A-scan ultrasound gives us one dimensional information about the area of interest in the body being examined. Paranasal sinuses are empty air-filled cavities whose functions are to support the weight of the skull, introduce resonance to voice and condition the respired air. They are located in the nasal cavity -maxillary sinuses, above the eyes-frontal sinuses, between the eyes -ethmoidal sinuses and behind the ethmoids- sphenoidal sinuses. The objective of our project is to design an A-mode ultrasound system for the detection of paranasal sinusitis, primarily maxillary sinus. The existent conventionally used methods for detection of paranasal sinuses are the X-ray and CT methods. This amounts to large radiation dose every time the patient undergoes an examination and is more expensive. The reasons behind choosing to use the ultrasound method are that it is relatively inexpensive and can be made portable. It is safe as no ionizing radiation is used. Since the ultrasound technique has limited bone penetration which restricts its use to maxillary sinuses alone.

Nasal Cavities and Frontal Sinuses

2013 ◽  
pp. 93-109 ◽  
Author(s):  
Jimmy Saunders ◽  
Tobias Schwarz
Keyword(s):  
Nasal Cavities ◽  
Frontal Sinuses

Acoustic rhinometry: influence of paranasal sinuses

1996 ◽  
Vol 80 (5) ◽  
pp. 1589-1594 ◽  
Author(s):  
O. Hilberg ◽  
O. F. Pedersen
Keyword(s):  
Nasal Cavity ◽  
Posterior Part ◽  
Acoustic Rhinometry ◽  
Nasal Cavities ◽  
Before And After ◽  
The Difference ◽  
Magnetic Resonance Imaging Mri ◽  
Measured Volume ◽  
Maxillary Sinuses ◽  
Made In

The influence of the maxillary sinuses in acoustic rhinometry (AR) has not been evaluated, and this is the aim of the present study. We examined six subjects with AR and magnetic resonance imaging (MRI) after nasal decongestion to compare the area-distance relationships determined by the two methods. From the MRI data we obtained copies of the nasal cavities with and without maxillary sinuses, which were made in plastic by a stereolithographic method. AR curves from models without maxillary sinuses differed from AR curves with sinuses included but were in agreement with MRI curves without inclusion of sinuses. A similar difference in AR was seen in two subjects before and after the nasal cavities were flushed with saline to fill up the maxillary sinuses. The measured volume in the first 50 mm of the nasal cavity models was unaffected by the sinuses, but the volume in the first 70 mm corresponding to the length of the nasal cavity septum was increased slightly but significantly (from 10.8 to 11.3 cm3; P = 0.05). The presence of maxillary sinuses increased the volume of the epipharynx (70-100 mm from the nostril) from 12.2 to 21.3 cm3 (P < 0.01), and this increase was not due to the influence from the contralateral nasal cavity. We conclude that the maxillary sinuses may significantly contribute to the acoustically determined areas in the posterior part of the nasal cavity and the epipharynx, especially during decongestion, and may explain a part of the difference between area-distance curves obtained by AR and MRI, whereas contribution from the contralateral nasal cavity does not.

scholarly journals Polarization of protease-activated receptor 2 (PAR-2) signaling is altered during airway epithelial remodeling and deciliation

2020 ◽  
Vol 295 (19) ◽  
pp. 6721-6740 ◽  
Author(s):  
Ryan M. Carey ◽  
Jenna R. Freund ◽  
Benjamin M. Hariri ◽  
Nithin D. Adappa ◽  
James N. Palmer ◽  
...  
Keyword(s):  
Nasal Polyps ◽  
Squamous Metaplasia ◽  
Beat Frequency ◽  
Primary Cultures ◽  
Middle Turbinate ◽  
Airway Epithelial ◽  
Ciliated Cells ◽  
Epithelial Morphology ◽  
Epithelial Remodeling ◽  
Protease Activated Receptor 2

Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously-expressed PAR-2. Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI–H520 squamous cells increased intracellular calcium levels and granulocyte macrophage–colony-stimulating factor, tumor necrosis factor α, and interleukin (IL)-6 secretion. RPMI 2650 cells cultured at an air–liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists. However, well-differentiated primary nasal epithelial ALIs responded only to basolateral PAR-2 stimulation, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine secretion. We exposed primary cells to disease-related modifiers that alter epithelial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrations and times that altered epithelial morphology without causing breakdown of the epithelial barrier to model early disease states. These altered primary cultures responded to both apical and basolateral PAR-2 stimulation. Imaging nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates, exhibit apical calcium responses to PAR-2 stimulation. However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from nonciliated cells. Altered PAR-2 polarization in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled proteases.

Stromal Cell Atypia in Sinonasal Polyposis

1986 ◽  
Vol 95 (3) ◽  
pp. 321-322 ◽  
Author(s):  
John G. Batsakis
Keyword(s):  
Stromal Cells ◽  
Nasal Polyps ◽  
Stromal Cell ◽  
Intercellular Fluid ◽  
Cellular Atypia ◽  
Vascular Compromise ◽  
Sinonasal Polyposis ◽  
Cell Atypia

Cellular atypia in stromal cells of nasal polyps is a peculiar response in fibroblasts or fibrohistiocytes to increased intercellular fluid and/or vascular compromise. Adherence to established histologic criteria will eliminate misjudging these cytologic changes as sarcomas.

Smoking is an independent association of squamous metaplasia in Chinese nasal polyps

2015 ◽  
Vol 6 (1) ◽  
pp. 66-74 ◽  
Author(s):  
Tian Gao ◽  
Chew Lip Ng ◽  
Chunwei Li ◽  
Ying Ying Li ◽  
Chen Duan ◽  
...  
Keyword(s):  
Nasal Polyps ◽  
Squamous Metaplasia ◽  
Independent Association
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