scholarly journals Hepatocellular carcinoma presenting with pyrexia and leukocytosis: A case report

2017 ◽  
Vol 70 (1-2) ◽  
pp. 48-52
Author(s):  
Srdjan Stosic ◽  
Sanja Stojanovic ◽  
Stevan Idjuski ◽  
Jelena Stosic
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Liver Abscess ◽  
Therapeutic Response ◽  
Left Lobe ◽  
Focal Lesion ◽  
Abdominal Ultrasonography ◽  
Focal Hepatic Lesions ◽  
Hepatic Lesions

Introducion. This type of hepatocellular carcinoma is characterized by fever and persistent leukocytosis. Case report. This is a report of a patient with a long term fever accompanied by persistent leukocytosis. Abdominal ultrasonography revealed a focal lesion in the left hepatic lobe, whereas, computed tomography/magnetic resonance imaging findings were consistent with a liver abscess. The patient received therapy for liver abscess, without improvement. He underwent left lobe segmentectomy 3, with histological features of hepatocellular carcinoma (pseudoglandular type). Conclusion. In patients with focal hepatic lesions accompanied with raised temeparature and persistent leukocytosis, without adequate therapeutic response, this clinicopathological type of hepatocellular carcinoma should be considered.

Role of MRI in Detecting and Characterizing Small Hepatic Focal Lesions

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Rania Ali Maarouf ◽  
Ali Haggag Ali ◽  
Mahmoud Abdelatif Onsy
Keyword(s):  
Tumor Staging ◽  
Left Lobe ◽  
Diagnostic Process ◽  
Liver Imaging ◽  
Focal Lesions ◽  
Focal Hepatic Lesions ◽  
Malignant Lesions ◽  
Hepatic Lesions ◽  
The Right

Abstract Background Despite the recent advances in liver imaging, the detection and characterization of small hepatic focal lesions is still a real challenge. Particularly in cancer patients where the characterization of a small HFL as thus the precise tumor staging is critical for optimal treatment planning. Aim of the Work To explore the effectiveness, and hence the clinical utility, of MRI detection and characterization of small focal hepatic lesions either only discovered on MRI or as a further work up of CT/US-indeterminate lesions. Patients and Methods We reviewed our database for individuals who underwent liver MR imaging between March 2018 and March 2019 for the evaluation of small hepatic lesions that were discovered for the first time or had been previously visualized on routinely performed CT and had been considered indeterminate. Results The present study included 44 patients of which 26 were males (59.1%) and 18 were females (40.9%). The age range of the study group was 19 to 77 years. The mean age for Malignant lesions was 51 years. The right lobe of liver was involved in 23 cases (52.3%), left lobe in 5 cases (11.4%) and both lobes in 16 cases (36.4%). There were 30 (68.18%) benign, 13 (29.54%) malignant lesions and 1 (2.3%) indeterminate, hemangiomas were predominant in benign lesions whereas hepatocellular carcinomas were predominant in malignant lesions. N'TRI could characterize 92% cases. Conclusion The diagnostic process of small hepatic focal lesions, either detection or characterization or both, continues to represent a challenge. Contrast-enhanced MR can accurately detect and characterize majority of small hepatic focal lesions.

scholarly journals Long-term follow-up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report

2017 ◽  
Vol 14 (4) ◽  
pp. 4853-4856 ◽  
Author(s):  
Jung Gil Park ◽  
Won Young Tak ◽  
Soo Young Park ◽  
Young Oh Kweon ◽  
Se Young Jang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Complete Remission ◽  
Advanced Hepatocellular Carcinoma ◽  
Sorafenib Therapy ◽  
Long Term Follow Up

scholarly journals Long-term sustained complete response with off-therapy to sorafenib in advanced hepatocellular carcinoma: a case report

Kanzo ◽  
2020 ◽  
Vol 61 (5) ◽  
pp. 255-261
Author(s):  
Takeshi Koujima ◽  
Yoshikatsu Endo ◽  
Takeharu Yamamoto ◽  
Toshifumi Tada ◽  
Kazuhiko Morii ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Complete Response ◽  
Advanced Hepatocellular Carcinoma

scholarly journals A Case Report on a Large, Peduncular Intra-abdominal Hepatocellular Carcinoma Extending into the Retroperitoneum

2020 ◽  
Author(s):  
Dana M Omer ◽  
Jordan Dozier ◽  
Zongxian Cao ◽  
Hongfa Zhu ◽  
Donald McCain
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Surgical Intervention ◽  
Partial Gastrectomy ◽  
Left Lobe ◽  
R0 Resection ◽  
Liver Malignancy ◽  
Operative Planning ◽  
History Of ◽  
Viral Hepatitis Infection

Abstract Background Hepatocellular carcinoma is a primary liver malignancy often caused by viral hepatitis infection due to chronic inflammation and persistent cytokine release. Although rare, patients may present with large, pedunculated hepatocellular neoplasms that extend into the intra-abdominal space. Here, we present a case report on a 66-year-old male who was found to have such a mass that required careful pre-operative planning to complete a challenging, yet worthwhile, surgical intervention with R0 resection. Case Presentation A 66-year-old Caucasian male with a history of Hepatitis C presented with 4-5 months of abdominal pain, distention and weight loss. Imaging revealed a large heterogenous mass attached to the left lobe of the liver, with compression of the stomach, transverse colon and abdominal wall. Biopsy revealed hepatocellular carcinoma with extensive necrosis and ultimately the patient required surgical intervention, which required resection of omentum, partial gastrectomy, hepatectomy and extensive dissection of the mass to separate the tumor from the remaining intra-abdominal structures and the retroperitoneum. Conclusion Peduncular hepatocellular carcinomas vary in presentation and difficulty of resection. The prognosis and probability of successful surgical intervention depends on the level of differentiation, early staging, size of the neoplasm and invasion into surrounding structures. In this case, R0 resection was successfully performed.

Plasma Osteopontin Level as a Diagnostic Marker of Hepatocellular Carcinoma in Patients with Radiological Evidence of Focal Hepatic Lesions

2013 ◽  
Vol 99 (1) ◽  
pp. 100-107 ◽  
Author(s):  
Ashraf Khalil ◽  
Jamalat Elgedawy ◽  
Mohammed F Faramawi ◽  
Ashraf Elfert ◽  
Ibrahim Salama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Malignant Tumors ◽  
Treatment Options ◽  
Alpha Fetoprotein ◽  
Egyptian Patients ◽  
Diagnostic Role ◽  
Focal Hepatic Lesions ◽  
Serum Alpha Fetoprotein ◽  
Hepatic Lesions

Aims Hepatocellular carcinoma is one of the most aggressive malignant tumors and has limited treatment options. Needle-guided biopsies have been utilized as a tool to diagnose malignant focal hepatic lesions. These techniques are discouraged because of their complications. Nowadays, alpha fetoprotein is the most widely used tumor marker for screening and diagnosis of hepatocellular carcinoma. Nevertheless, this marker has limitations. The diagnostic role of plasma osteopontin as an adjuvant or alternative marker to alpha fetoprotein to detect hepatocellular carcinoma in Egyptian patients with focal hepatic lesions was evaluated in this study. Subject and methods Eighty participants were recruited from the Egyptian National Liver Institute and were self-assigned to three groups, namely, focal hepatic lesions (n = 40), liver cirrhosis (n = 20), and controls (n = 20). Participants' plasma osteopontin and serum alpha fetoprotein levels were determined and were compared across the three groups. Results The discriminatory ability of plasma osteopontin for hepatocellular carcinoma was lower than that of alpha fetoprotein. Osteopontin and alpha fetoprotein were not correlated with each other. Neither the gender nor the age of the patients showed a significant association with plasma osteopontin level. Conclusion Measuring plasma osteopontin level alone has no advantage over serum alpha fetoprotein in patients with focal hepatic lesions due to chronic liver disease.

scholarly journals Endoscopic ultrasound-guided radiofrequency ablation for hepatocellular carcinoma in cirrhosis: a case report test for efficacy and future perspectives

2020 ◽  
Vol 08 (11) ◽  
pp. E1713-E1716
Author(s):  
Germana de Nucci ◽  
Cristina della Corte ◽  
Raffaella Reati ◽  
Nicola Imperatore ◽  
Ilaria Arena ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Radiofrequency Ablation ◽  
Endoscopic Ultrasound ◽  
Ultrasound Guided ◽  
Neoplastic Tissue ◽  
Generator System ◽  
Percutaneous Approach ◽  
A New Technique ◽  
Hepatic Lesions

Abstract Background The percutaneous approach allows for effective and safe treatment of liver lesions. But in case of subcapsular or left segments location, this approach seems to be less effective or unsafe. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is a new technique used to treat pancreatic and neuroendocrine tumors in patients unfit for surgery. Methods Hereby, we describe the case of a 70-year-old patient with cirrhosis with a large subcapsular hepatocellular carcinoma (HCC) in II-III-IVb segments, in which surgery or percutaneous therapies were not feasible, treated with EUS-RFA. The HCC was treated using an EUS-RFA (EUSRA) system, which consists of a 19G water-cooled monopolar RFA needle and a dedicated generator system. Results After a multidisciplinary discussion, the lesion was ablated in two different sessions, which resulted in destruction of about 70 % of neoplastic tissue. A second step surgery was required but initially refused by the patient. Conclusions EUS-RFA could be an effective way to treat left hepatic lesions not manageable with conventional percutaneous methods. This case report does not highlight concerns about safety of this approach and this observation needs to be validated in a larger cohort of patients with cirrhosis.

Ascitic Fluid Cytokines in Chronic Liver Disease: A Possible Prognostic Tool

2021 ◽  
Author(s):  
Shimaa atta ◽  
Manal Kamel ◽  
Wafaa Mansour ◽  
Taghreed Hussein ◽  
Kesmat Maher ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Ascitic Fluid ◽  
Serum Levels ◽  
Malignant Ascites ◽  
Focal Lesions ◽  
Prognostic Tool ◽  
Significant Difference ◽  
Focal Hepatic Lesions ◽  
Hepatic Lesions ◽  
Fluid Levels

Introduction: Malignant ascites results from imbalance between protein in the peritoneal cavity and absorption of fluids via the lymphatic system. More than twenty interleukins are known to play an important role in the protection against tumors. Materials and methods: Ascitic fluid IL1B, IL2, IL4, IL6, IL10, TNFα, and IFNγ levels were assessed in forty-five patients with liver cirrhosis and ascites as judged by histopathological and ultra-sonographic findings. They were divided into two groups according to presence of hepatic focal lesions. Ten patients with focal hepatic lesions were randomly selected and subjected to analysis of serum levels of IL2 and IL10. Results: Ascitic fluid IL-4, IL-6 and IL-10 levels were found to be significantly higher in patients with hepatocellular carcinoma than patients with cirrhosis. TNFα, and IFNγ were also found to be higher in hepatocellular carcinoma than patients with cirrhosis but with no significance. On the other hand, there was no significant difference in levels of IL1B and IL2 between the two groups. Ascitic fluid IL2 and IL10 levels were found to be higher in ascitic fluid than in serum of the same patients. Conclusion: Ascitic fluid levels of IL-4, IL-6 and IL-10 are higher in hepatocellular carcinoma patients than patients with cirrhosis alone. Levels of ascitic fluid IL2 and IL10 were proved to be a better prognostic tool than their levels in sera of the same patients. To conclude; patients with cirrhosis may be subjected to schedualed examination of ascitic fluid cytokine to predect transformation into hepatocellular carcinoma.

scholarly journals Sarcomatoid hepatocellular carcinoma resembling a liver abscess: A case report

2013 ◽  
Vol 21 (36) ◽  
pp. 4210
Author(s):  
Wen-Juan Zhang ◽  
Yu Guo ◽  
Shu-Lin Jiang ◽  
Cui-Jie Gong ◽  
Yong-Mei Gao
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Liver Abscess
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