scholarly journals Transmandibular and transcervical surgical approach in treatment of tongue base cancers - ten-year results

2014 ◽  
Vol 67 (suppl. 1) ◽  
pp. 12-19
Author(s):  
Rajko Jovic ◽  
Danijela Dragicevic ◽  
Karol Canji ◽  
Jugoslav Gasic ◽  
Masa Djozic
Keyword(s):  
Survival Rate ◽  
Tongue Cancer ◽  
Distant Metastases ◽  
Functional Results ◽  
Second Primary ◽  
Swallowing Function ◽  
Patients With Cancer ◽  
Base Of Tongue ◽  
Neck Metastases ◽  
Transmandibular Approach

Introduction. The aim of this study was to present oncological and functional results of surgical treatment of the base of tongue cancer by analyzing retrospectively 115 patients treated during a ten-year period. During this period, 150 patients with cancer of the base of tongue were diagnosed, which accounts for 5.6% of all diagnosed head and neck cancers and 24.1% of all oropharyngeal cancers. In 111 patients (96.5%), planocellular carcinoma with various degrees of differentiation was pathohistologically verified. Neck metastases were found in 88 (76.5%) patients. Advanced III and IV stages of disease were verified in 92.9% of patients (stage III in 23.4%, IV A in 59.1%, IV % B in 10.4%). Transmandibular approach was performed in 5.2% of patients, while 94.8% of patients were approached through pharynx The defects were covered by primary reconstruction; the pectoralis major myocutaneous flap was used in 4 patients . During immediate postoperative period, 17 (14.7%) patients developed complications: bleeding occurred in 7 patients (6%), fistula and wound infection developed in 5 (4.3%) and 11 (9.5%) patients, respectively. Postoperatively, 61 (53%) patients were treated by radiation therapy. Swallowing function was resumed in all patients except in three, who underwent gastrostomy due to the lesion of both hypoglossal nerves. Gasrostoma was closed after six months when swallowing was resumed. Local and regional recurrence developed in 13 (11.3%) and 24 (20.8%) patients, respectively, and distant metastases developed in 4 (3.5%) patients. Second primary cancer was diagnosed in 9 (7.8%) patients Disease-specific 3-year survival rate (according to the T category) was 73%, 60%, 45% and 21% in patients with T1, T2, T3 and T4, respectively. Diseasespecific 3-year survival rate (according to category N) was 68% in N0 and 32%) in N +. The overall 3-year survival rate was 42%.

scholarly journals Whole-Exome Sequencing of HPV Positive Tonsillar and Base of Tongue Squamous Cell Carcinomas Reveals a Global Mutational Pattern along with Relapse-Specific Somatic Variants

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 77
Author(s):  
Andreas Ährlund-Richter ◽  
Stefan Holzhauser ◽  
Tina Dalianis ◽  
Anders Näsman ◽  
Michael Mints
Keyword(s):  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Tongue Cancer ◽  
Distant Metastases ◽  
Distant Recurrence ◽  
Local Relapse ◽  
University Hospital ◽  
Curative Intent ◽  
Base Of Tongue ◽  
Whole Exome

To identify predictive/targetable markers in human papillomavirus positive (HPV+) tonsillar and base of tongue cancer (TSCC/BOTSCC), whole-exome sequencing (WES) of tumours of patients with/without recurrence was performed. Forty primary tumours and adjacent normal tissue were separated by micro-dissection from formalin-fixed paraffin-embedded tissue from patients treated with curative intent 2000–2014 at Karolinska University Hospital. Successful sequencing was obtained in primary tumours of 18 patients without and primaries of 17 with local or distant recurrence, as well as in 10 corresponding recurrences (i.e., five local relapses and five distant metastases) from these 17 patients. One variant—a high-impact deletion in the CDC27 gene—was observed only in primaries of 5/17 patients that had a recurrence after full treatment but in none of those without recurrence. In addition, 3 variants and 26 mutated genes, including CDC27, BCLAF1 and AQP7, were present in at least 30% of all primary tumours independent of prognosis. To conclude, a CDC27 deletion was specific and found in ~30% of samples from patients with a local relapse/distant metastasis and could, therefore, potentially be a prospective marker to predict prognosis. Commonly mutated genes, such as BCLAF1, should be further studied in the context of targeted therapy.

ANALISIS KASUS KANKER LIDAH DALAM KONTEKS ASUHAN KEPERAWATAN DENGAN PENDEKATAN COMFORT THEORY MODEL

2018 ◽  
Vol 12 (02) ◽  
Author(s):  
Dewi Nurviana Suharto
Keyword(s):  
Nursing Care ◽  
Tongue Cancer ◽  
Theory Model ◽  
Breathing Patterns ◽  
Patients With Cancer ◽  
Starting Point ◽  
Squamous Cell Carcinoma Tongue ◽  
Very High ◽  
Carcinoma Tongue ◽  
Comfort Theory

ABSTRACT The prevalence of patients with cancer increase every year. Tongue cancer is a type of malignancy of the tongue, and almost 95% is squamous cell carcinoma. Tongue cancer is a cancer with high progression with bad prognosis so that the mortality rate is very high and often causes discomfort. Comfort is the starting point of various healing that will be achieved by the client. Improvements in client conditions will not be achieved if the need of comfort is not fulfilled. In nursing care the problems that arise in tongue cancer are chronic pain, nutrient imbalance: less than body needs, and ineffective breathing patterns. Analysis of residency practice processes shows that comfort theory can be applied to patients with malignancy cases in nursing care, as it can identify patients' holistic discomfort from the physical, psychospiritual, sociocultural and environmental aspects.Keyword : Comfort Theory, Tongue Cancer

scholarly journals Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients

2004 ◽  
Vol 112 (6) ◽  
pp. 1015-1019 ◽  
Author(s):  
Liselotte Dahlgren ◽  
Hanna (Mellin) Dahlstrand ◽  
David Lindquist ◽  
Anders Högmo ◽  
Linda Björnestål ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Tongue Cancer ◽  
Base Of Tongue ◽  
Favorable Prognostic Factor ◽  
Mobile Tongue

Dysphagia following Various Degrees of Surgical Resection for Oral Cancer

1992 ◽  
Vol 101 (2) ◽  
pp. 138-141 ◽  
Author(s):  
Minoru Hirano ◽  
Hidetaka Matsuoka ◽  
Yasunao Kuroiwa ◽  
Kiminori Sato ◽  
Shinzo Tanaka ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Surgical Resection ◽  
Tongue Cancer ◽  
Tube Feeding ◽  
The Other ◽  
Surgical Removal ◽  
Swallowing Function ◽  
Pharyngeal Wall ◽  
Swallowing Problems ◽  
Nasogastric Tube Feeding

Postoperative swallowing problems were investigated in 20 patients who had undergone various degrees of surgical resection for oral cancer. The swallowing problems were evaluated on the basis of type of food, degree of aspiration, and duration of postoperative nasogastric tube feeding. Two patients with tongue cancer who had had hemiglossectomy without reconstruction ate normal food without aspiration within a week after operation. Eight patients who had undergone two- to three-quarter glossectomy for tongue cancer ate gruel with no or occasional liquid aspiration. Among 4 patients who had had near-total or total glossectomy for tongue cancer, 3 ate thin gruel or liquid with occasional aspiration. The other could not eat orally because of consistent severe aspiration. One patient with mouth floor cancer underwent resection of the mouth floor in combination with hemiglossectomy and she ate gruel without aspiration. Among 5 patients with mouth floor cancer who had had surgical removal accompanied by near-total or total glossectomy, 3 ate gruel with no or occasional liquid aspiration, 1 ate thin gruel with no aspiration, and the other could not eat orally. A diagnosis of T4 lesions, extensive removal of the tongue base, removal of the geniohyoid and mylohyoid muscles, and removal of the lateral pharyngeal wall were significantly related to poor swallowing function.

The role of human papillomavirus in the increased incidence of base of tongue cancer

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Per Attner ◽  
Juan Du ◽  
Anders Näsman ◽  
Lalle Hammarstedt ◽  
Torbjörn Ramqvist ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Tongue Cancer ◽  
Base Of Tongue

scholarly journals Human papillomavirus and survival in patients with base of tongue cancer

2010 ◽  
Vol 128 (12) ◽  
pp. 2892-2897 ◽  
Author(s):  
Per Attner ◽  
Juan Du ◽  
Anders Näsman ◽  
Lalle Hammarstedt ◽  
Torbjörn Ramqvist ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Tongue Cancer ◽  
Base Of Tongue
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