scholarly journals Predictors of deterioration of symptoms and quality of life in patients with sarcoidosis

2013 ◽  
Vol 66 (suppl. 1) ◽  
pp. 77-83
Author(s):  
Branislav Gvozdenovic ◽  
Violeta Mihailovic-Vucinic ◽  
Mira Vukovic ◽  
Aleksandar Gvozdenovic ◽  
Aleksandra Dudvarski-Ilic ◽  
...  

Introduction. The most frequent clinical outcomes in sarcoidosis patients are typically focused on the objective measurements of functions of the involved organs, but, generally, they do not take into account the individual perception of patients? everyday functioning. The aim of this study was to determine the type of association between the subjective disease outcomes and other objective conventional parameters in patients with sarcoidosis. Material and Methods. In the cross-sectional study including 172 sarcoidosis patients (122 females), quality of life was measured by a generic instrument, i.e. fifteen-dimensional measure of health-related quality of life together with a respiratory specific instrument, i.e. St George?s Respiratory Questionnaire; symptoms of fatigue were measured by Fatigue Scale and dyspnea was measured by the Basal Dyspnea Index. Body-mass index and the course of the disease (acute vs. chronic) were also evaluated. Pulmonary function was assessed by spirometry. Results. Acute sarcoidosis was present in 48 (28%) patients. Mean body mass index was 27.01?5.2. Only 20 (12%) patients had lower forced expiratory volume in one second values (<80%) that indicated the existance of obstructive ventilatory impairment. Multivariate linear regression analysis revealed that body mass index, clinical course of disease and spirometric parameter forced expiratory volume in one second were the significant predictors (R2=0.929, p<0.01) of sarcoidosis related fatigue (B=0.061, B=0.406, B=0.452; respectively). Body mass index and forced expiratory volume in one second were the only parameters that significantly predicted both patients? quality of life (R2=0.932; B=0.017, B=0.263) and dyspnea (R2=0.847; B=0.025, B=0.668). Conclusions. It is important to measure both subjective patient-reported outcomes and objective disease parameters in sarcoidosis since they represent different aspects of the disease. All applied measuring instruments for the examined subjective outcomes demonstrated good measuring properties.

2017 ◽  
Vol 58 (5) ◽  
pp. 331
Author(s):  
Tullika Garg ◽  
Amanda J. Young ◽  
Korey A. Kost ◽  
Alyssa M. Park ◽  
John F. Danella ◽  
...  

2017 ◽  
Vol 25 (7) ◽  
pp. 2169-2177 ◽  
Author(s):  
Amerigo Rossi ◽  
Carol Ewing Garber ◽  
Gurpreet Kaur ◽  
Xiaonan Xue ◽  
Gary L. Goldberg ◽  
...  

2017 ◽  
Vol 19 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Aditya Vedantam ◽  
Daniel Hansen ◽  
Valentina Briceño ◽  
Alison Brayton ◽  
Andrew Jea

OBJECTIVE There is limited literature on patient-reported outcomes (PROs) and health-related quality of life (HRQOL) outcomes in pediatric patients undergoing surgery for craniovertebral junction pathology. The aim of the present study was to assess surgical and quality of life outcomes in children who had undergone occipitocervical or atlantoaxial fusion. METHODS The authors retrospectively reviewed the demographics, procedural data, and outcomes of 77 consecutive pediatric patients who underwent posterior occipitocervical or atlantoaxial fusion between 2008 and 2015 at Texas Children's Hospital. Outcome measures (collected at last follow-up) included mortality, neurological improvement, complications, Scoliosis Research Society Outcomes Measure–22 (SRS-22) score, SF-36 score, Neck Disability Index (NDI), and Pediatric Quality of Life Inventory (PedsQL). Multivariate linear regression analysis was performed to identify factors affecting PROs and HRQOL scores at follow-up. RESULTS The average age in this series was 10.6 ± 4.5 years. The median follow-up was 13.9 months (range 0.5–121.5 months). Sixty-three patients (81.8%) were treated with occipitocervical fusion, and 14 patients (18.1%) were treated with atlantoaxial fusion. The American Spinal Injury Association (ASIA) grade at discharge was unchanged in 73 patients (94.8%). The average PRO metrics at the time of last follow-up were as follows: SRS-22 score, 4.2 ± 0.8; NDI, 3.0 ± 2.6; the parent's PedsQL (ParentPedsQL) score, 69.6 ± 22.7, and child's PedsQL score, 75.5 ± 18.7. Multivariate linear regression analysis revealed that older age at surgery was significantly associated with lower SRS-22 scores at follow-up (B = −0.06, p = 0.03), and the presence of comorbidities was associated with poorer ParentPedsQL scores at follow-up (B = −19.68, p = 0.03). CONCLUSIONS This study indicates that occipitocervical and atlantoaxial fusions in children preserve neurological function and are associated with acceptable PROs and ParentPedsQL scores, considering the serious nature and potential for morbidity in this patient population. However, longer follow-up and disease-specific scales are necessary to fully elucidate the impact of occipitocervical and atlantoaxial fusions on children.


2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Nur Aini ◽  
Lilis Setyowati

Paper factory in Indonesia contributes greatly to the country's economy, especially the non-oil export sector. However, the result of industrial process waste or waste causes environmental pollution problems if it is not managed properly and has an impact on the surrounding community. The purpose of this study was to identify the respiratory status function of the impact of paper mill waste. This research is descriptive-explorative. That aims to describe variables related to respiratory problems, sociodemographic characteristics of factory workers include: age, sex, use of PPE (personal protective equipment), BMI (body mass index), respiratory function examined by Spirometry and instrument SGRQ. The population in this study were factory workers, sampling using purposive sampling. Forty-two people included in this study, conducted in July-August 2019. Respiratory function was measured using SGRQ (St George's Respiratory Questionnaire) instrument to measure the quality of life on patient respiratory function and Spirometry to measure FEV 1 / FVC (forced expiratory volume in 1 second). Results 41 (93.18%) abnormal spirometry values, mean FEV 1/FVC 65.04% (SD: 23:53), mean spirometry prediction of 77.27% (SD: 24.98). SGRQ shows a worse quality of life for factory workers. The conclusions of the study respondents had an abnormal respiratory function. Encourage factory workers to use PPE and improve their nutritional status to reduce symptoms in their respiratory problems. The community cannot leave the job even though it hurts health because the work is a source of family income so they may not leave it. Keywords: SGRQ, respiratory function, paper factory waste, Spirometry Abstrak : Pabrik kertas di Indonesia memberikan kontribusi sangat besar dalam bidang perekonomian Negara, terutama bidang ekspor non migas. Namun, limbah hasil akhir proses industri atau sampah menimbulkan masalah pencemaran lingkungan jika tidak dikelola dengan baik dan benar dan berdampak pada masyarakat sekitar. Tujuan penelitian ini adalah mengidentifikasi fungsi status respirasi akibat dampak dari limbah pabrik kertas. Desain penelitian ini adalah deskriptif eksploratif yaitu bertujuan untuk mendeskripsikan atau menggambarkan sejumlah variabel yang berkaitan dengan masalah, antara lain karakteristik sosiodemografi pekerja pabrik meliputi : usia, jenis kelamin, penggunaan APD (alat pelindung diri), BMI (body mass index), fungsi status respirasi yang diperiksa dengan spirometri dan instrumen SGRQ. Populasi dalam penelitian ini adalah pekerja pabrik, pengambilan sample dengan teknik purposive sampling, sebanyak  42 orang. Penelitian dilakukan pada bulan Juli – Agustus 2019. Fungsi status respirasi diperiksa menggunakan instrumen SGRQ (St George’s Respiratory Questionnaire untuk mengukur kualitas hidup pada fungsi pernafasan dan spirometri untuk mengukur FEV 1/FVC (forced expiratory volume in 1 second). Hasil 41 orang (93,18 %) nilai spirometri tidak normal, mean FEV 1/FVC 65.04 % (SD : 23.53), mean prediksi spirometri 77,27% (SD: 24,98). SGRQ menunjukkan kualitas hidup buruk. Kesimpulan hasil penelitian, sebagian besar responden memiliki fungsi respirasi yang tidak normal. Disarankan kepada pekerja agar menggunakan APD dan meningkatkan status gizinya sehingga bisa mengurangi gejala–gejala pada masalah pernafasan, karena pekerjaan tersebut adalah sumber income keluarga sehingga mereka tidak mungkin meninggalkannya. Kata Kunci : SGRQ, fungsi pernafasan, limbah pabrik kertas, spirometri


Pulmonology ◽  
2021 ◽  
Author(s):  
Jhonatan Betancourt-Peña ◽  
Juan Carlos Ávila-Valencia ◽  
Diana Milena Diaz-Vidal ◽  
Vicente Benavides-Córdoba

2021 ◽  
Vol 13 (4) ◽  
pp. 2341
Author(s):  
Gabriel González-Valero ◽  
Josep Vidal-Conti ◽  
Félix Zurita-Ortega ◽  
Pere Palou-Sampol

Current research shows that individuals with intellectual disabilities do not engage in enough physical activity to acquire health benefits. However, cooperative learning has been shown to be an effective tool for inclusion and for improving healthy physical habits. The aim of this study is to contrast an explanatory model which incorporates quality of life, active time in cooperative activities, body mass index and age, as well as to analyze, using multi-group structural equations, the existing associations according to the sex of subjects with intellectual disabilities. The convenience sampling used allowed the collection of data from a total of 156 subjects in Granada (Spain), aged between 18–55 years. In terms of gender, the sample was homogeneous, representing 52.6% (n = 82) for women and 47.4% (n = 74) for men. The active time during the cooperative learning was recorded with the Xiaomi Mi Band 2 activity band, for the quality of life scale (GENCAT) was used, and the body mass index was calculated through its standardized equation. Age was directly associated with body mass index in both sexes. Likewise, age was positively related to the active time of women. Quality of life was directly associated with active time and body mass index was inversely related to active time. This study shows the importance of active time during work and cooperative learning in individuals with intellectual disabilities, as it is associated with an improvement in the quality of life and a reduction in the problems of sedentarism, overweight, and obesity.


2021 ◽  
pp. 1-8
Author(s):  
Alexander Pantelyat ◽  
Lenora Higginbotham ◽  
Liana Rosenthal ◽  
Diane Lanham ◽  
Vanessa Nesspor ◽  
...  

<b><i>Introduction:</i></b> There is growing interest in using patient-reported outcomes as end points in clinical trials, such as the progressive supranuclear palsy quality of life (PSP-QoL) scale. However, this tool has not been widely validated and its correlation with validated motor scales has not been explored. To evaluate the potential utility of using PSP-QoL as an outcome, it is important to examine its relationship with a standard scale used to evaluate neurologic parameters, such as the PSP Rating Scale. <b><i>Methods:</i></b> PSP-QoL and PSP Rating Scale scores were gathered from 60 clinically diagnosed PSP patients, including patients with Richardson syndrome PSP (PSP-RS, <i>n</i> = 43) and those with non-RS PSP variants (<i>n</i> = 17). Linear regression analysis adjusted for age, sex, and disease duration was used to evaluate the cross-sectional relationship between the total and subscale scores of the 2 instruments. <b><i>Results:</i></b> Among 60 PSP patients, there was a significant correlation between total PSP-QoL and PSP Rating Scale scores. The physical and mentation subscales of each instrument also demonstrated significant correlations. Comparisons among PSP subtypes indicated that worsening PSP-QoL Total and Physical subscale scores correlated with worsening PSP Rating Scale gait subscale scores more strongly for the non-RS PSP variants than for PSP-RS. <b><i>Discussion:</i></b> There is a significant association between the total scores and many of the subscale scores of the PSP-QoL and the PSP Rating Scale. Additionally, the relationship between these measures may differ for PSP-RS and non-RS variants. These findings suggest that the PSP-QoL may be useful in clinical trials as a patient-reported outcome measure. Large prospective multicenter studies utilizing the PSP-QoL are necessary to examine its relationship to disease evolution and changes in the PSP Rating Scale.


2008 ◽  
Vol 11 ◽  
pp. S105-S114 ◽  
Author(s):  
Hwee-Lin Wee ◽  
Yin-Bun Cheung ◽  
Wai-Chiong Loke ◽  
Chee-Beng Tan ◽  
Mun-Hong Chow ◽  
...  

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